Effect of Fluoride on Bone Formation and Strength in Japanese Quail

Chan, M. M.; Rucker, Robert B.; Zeman, Frances J.; Riggins, Richard S.

doi:10.1093/jn/103.10.1431

Cited by 27 publications

(9 citation statements)

References 22 publications

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“…2 Publication Number 352 of the Rijksstation voor Kleinveeteelt. 1988 Poultry Science 67: [950][951][952][953][954][955] and calcified bone ash (Chan et al, 1973). Addition of F to poultry diets significantly increases bone ash percentage (Chan et al, 1973;Riggins et al, 1974;Merkley, 1976;Huyghebaert et al, 1981;Van Toledo, 1981;Merkley and Miller, 1983;Huyghebaert and De Groote, 1986).…”

Section: Introductionmentioning

confidence: 99%

“…1988 Poultry Science 67: [950][951][952][953][954][955] and calcified bone ash (Chan et al, 1973). Addition of F to poultry diets significantly increases bone ash percentage (Chan et al, 1973;Riggins et al, 1974;Merkley, 1976;Huyghebaert et al, 1981;Van Toledo, 1981;Merkley and Miller, 1983;Huyghebaert and De Groote, 1986). As percentage of bone ash is usually positively correlated with bone-breaking strength (Rowland et al, 1967), one may expect that fluoridation also improves the strength of the leg or wing bones.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Dietary Fluoride on Performances and Bone Characteristics of Broilers and the Influence of Drying and Defatting on Bone-Breaking Strength

et al. 1988

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A trial with broiler males, housed in cages, was conducted to determine the effect of (added) dietary fluoride at 0, 200, and 400 mg/kg on performance and bone characteristics and the influence of preconditioning (drying, defatting) on bone-breaking strength. The F administration resulted in a significantly (P less than .05) lower weight gain. Feed conversion, however, was not affected. Tibial ash deposition and ash-percentage increased significantly (P less than .05) at both dietary levels of added F. Broiler males fed supplemented F had a significantly (P less than .05) higher incidence of tibial dyschondroplastic plugs and epiphyseal bone with looser structure, as judged macroscopically. Tibial bone strength was significantly (P less than .05) affected not only by dietary F level, but also by preconditioning, resulting in a significant interaction. Administration of F had a significantly negative or positive effect on breaking strength, depending on whether the measurements were carried out on fresh bones or dried (defatted) bones, respectively. This diverging response of F on breaking strength offers a valid explanation for the contradictory results in the literature, demonstrating at the same time that F supplementation of feed or drinking water should be discontinued as a method to improve bone-breaking strength.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of Dietary Fluoride on Performances and Bone Characteristics of Broilers and the Influence of Drying and Defatting on Bone-Breaking Strength

et al. 1988

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“…In other species it has been shown that the magnesium requirement and/or metabolism may be affected by phytate (McWard, 1969), potassium (Grace and O'Dell, 1970), high dietary fluoride (Chan et al, 1973) an J calcium and phosphorus (Kruse et al, 1932).…”

Section: Discussionmentioning

confidence: 99%

Magnesium Deficiency, Requirement and Toxicity in the Young Japanese Quail

1976

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Studies of magnesium deficiency, requirement and toxicity in the young Japanese quail (Coturnix coturnix japonica) were conducted. Day-old birds were fed an adequate purified diet containing 35% soy protein to 2 weeks of age. Residual magnesium in the diet without any added magnesium salts was 21 p.p.m. magnesium was supplied by graded amounts of MgSO4 to a total of 11 levels ranging from 125 to 2,000 p.p.m. Deficiency signs included poor growth, and occasionally excitability, gasping and convulsions. Most mortality occurred during the first 7 days. The maximum dietary magnesium concentrations that produced the minimal significant deviation from normal values for mortality, body weight, hemoglobin and tibia ash was 225, 200, 250 and 250 p.p.m., respectively. Based on these measurements, 300 p.p.m. magnesium is considered adequate to meet the young quail's requirement under the conditions of these experiments. With 2,000 p.p.m. magnesium, the only adverse effect was an increase in mortality. Between 200 and 1,000 p.p.m. magnesium there was a linear relationship between concentration of magnesium in the tibia and the log of the concentration of dietary magnesium. This suggests that tibia magnesium concentration might be useful for bioassay of magnesium in foodstuffs.

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“…Cohen et al [40] have suggested that the magnesium malabsorption found in 12 of 20 of their osteoporotic patients may account for this magnesium deficiency state [40], Lowered bone magnesium content has been reported in diabetes [32,36] and in otosclerotic bone [41]. Increased magnesium levels have been reported in human fluorotic bone [42,43] and in quail [44] and chick [45,46] studies. However, when fluoride-supplemented animals are placed on a low-magnesium diet, bone magnesium de creased [47], Early work by Pellegrino and Biltz [48] showed no difference in magnesium content between control sub jects and patients with renal disease of less than 2 or more than 2 years.…”

Section: Magnesium and Bone Diseasementioning

confidence: 99%