Effect of Fenugreek (Trigonella foenm greacum) Seed Dietary Levels on Lipid Profile and Body Weight Gain of Rats

Elmnan, Atta; Balgees, A.; Mangara, John L.

doi:10.3923/pjn.2012.1004.1008

Cited by 11 publications

(9 citation statements)

References 13 publications

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“…This effect found for body weight is consistent with results obtained by Petit et al; Sharma et al; Rao et al; and Elmnan et al that studied the effect of fenugreek seeds over metabolism of rats ( Trigonella foenum-graecum L.). They reported that saponins increased food consumption, thus resulting in increased weight gain in rats [26–29]. In phytochemical screening of P. mammosa it was determined that both extracts (aqueous and hydroalcoholic at 25%) contained saponins, in similar intensities, which could justify the same effect in this study.…”

Section: Resultssupporting

confidence: 65%

Acute Toxicity and Dermal and Eye Irritation of the Aqueous and Hydroalcoholic Extracts of the Seeds of “Zapote” Pouteria mammosa (L.) Cronquist

Dutok

Berenguer-Rivas

Rodríguez-Leblanch

et al. 2015

The Scientific World Journal

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The common use of Pouteria mammosa (L.) Cronquist, “Mamey or Zapote,” in food and ethnobotanic medicine shows its low or absent toxicity as fruit extracts prepared from seeds. However, it is essential to conduct security trials to scientifically support their use in drug therapy. This study evaluated the aqueous and hydroalcoholic extract (25%) Acute Oral Toxicity, obtained from the seeds of P. mammosa, in Sprague Dawley rats and dermal and eye irritability in New Zealand rabbits. The 404 and 405 acute dermal and eye irritation/corrosion guidelines were used, as well as the 423 Acute Oral Toxicity guideline, Acute Toxic Class Method of the Organization for Economic Cooperation and Development (OECD). The aqueous extract was located in the following category: not classified as toxic (CTA 5), while hydroalcoholic extract at 25% was classified as dangerous (CTA 4). Both extracts can be used without side reaction that irritates the skin which permitted classification as potentially not irritant. P. mammosa in the two extracts caused mild and reversible eye irritation, and it was classified as slightly irritating.

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Section: Resultssupporting

confidence: 65%

Acute Toxicity and Dermal and Eye Irritation of the Aqueous and Hydroalcoholic Extracts of the Seeds of “Zapote” Pouteria mammosa (L.) Cronquist

Dutok

Berenguer-Rivas

Rodríguez-Leblanch

et al. 2015

The Scientific World Journal

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“…Additionally, other reports (Eidi et al, 2007;Xue et al, 2007) demonstrated that, administration of ethanolic and aqueous extracts of Fenugreek, respectively decreased triglycerides, total cholesterol, LDL-c and increased HDL-c concentrations in diabetic rats. Previous reports (Elmnan et al, 2012) also reported that, Fenugreek seeds powder reduced total cholesterol and LDL-c concentration and increased HDL-c concentration in dose dependent manner (0.25-0.75%) in rats. In addition, other report (Moosa et al, 2006) demonstrated that oral administration of 25 g of Fenugreek seed produced significant reduction of total cholesterol and LDL-c without any changes in HDL-c concentration in hypercholesterolemic patients.…”

Section: Discussionmentioning

confidence: 61%

“…Therefore, It has been suggested that, saponins prevent the absorption of lipid either directly in the intestine or bind to bile acids during enterohepatic reabsorption mechanism (Madar and Odes, 1990). The crude fibers contents of Fenugreek seeds are one of the most hypocholesterolemic agent (Madar and Odes, 1990;Elmnan et al, 2012) because the presence of soluble fiber may block cholesterol absorption from the intestine (Lanksy et al, 1992). It is well known that, protein quality and quantity plays an important role on cholesterol levels.…”

Section: Discussionmentioning

confidence: 99%

Influence of Dietary Supplementation of Fenugreek (Trigonella foenum-graecum L.) on Serum Biochemical Parameters of Rats Fed High Cholesterol Diet

Elmahdi¹,

El-Bahr²

2014

International J. of Biological Chemistry

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Thirty-two rats were divided into four groups (8 rats/each) named as 1, 2, 3 and 4. Group 1 kept on basal diet and served as a control group. Whereas, group 2 kept on the basal diet mixed with 1% cholesterol (high cholesterol diet). Groups 3 and 4 kept on the high cholesterol diet mixed with Fenugreek seed powder 5 and 10%, respectively. Total cholesterol, low-density lipoprotein cholesterol (LDL-c) and alanine transaminase (ALT) activity were significantly increased (32.4±0.2; 12.2±1.5 mg dLG 1 ; 26.5±0.6 IU LG 1 ) whereas, high-density lipoprotein cholesterol (HDL-c) concentration was decreased significantly (11.9±1.6 mg dLG 1 ) in rats fed high cholesterol diet compared to control group (28.1±0.1; 6.0±1.3; 22.7±0.4; 13.9±1.5), respectively. Inclusion of both concentrations of Fenugreek in high cholesterol diet reduced serum total cholesterol (30.5±0.1; 29.5±0.5) and ALT activity (22.1±0.5; 21.7±0.7), respectively compared to rats fed high cholesterol diet and control groups. Histopathological findings revealed fatty changes in liver of rats fed high cholesterol diet which recovered by dietary supplementation of Fenugreek seed powder. Only, inclusion of lower concentration of Fenugreek in diet of rats fed high cholesterol reduced LDL-c concentration (6.2±1.2) and increased HDL-c concentration (15.0±1.0) compared to rats fed high cholesterol diet and the control group. Conclusively, inclusion of low dose of Fenugreek (5%) in ration of rats was recommended than the high dose (10%).

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“…Carbohydrate contents of fenugreek seeds were determined between 1.82 and 1.07% (Singh, Nair, Chand, & Naidu, 2013 Leucine, valine, lysine, and phenylalanine are major amino acids of fenugreek seeds (Singh et al, 2013). Elmnan, Balgees, and Mangara (2012) reported that fenugreek seed contained 28.60% protein, 14.04% crude fiber, 6.16% ether extract, and 4.65% ash. Abbas Ali et al (2012) reported that T. foenum-graecum seed contained 28% protein.…”

Section: Re Sul Ts a Nd Discussionmentioning

confidence: 99%

Effect of location on chemical properties, amino acid and fatty acid compositions of fenugreek (Trigonella foenum-graecum L.) seed and oils

Juhaimi

Şimşek

Özcan

et al. 2018

J Food Process Preserv

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Oil contents of samples were found low, and varied between 5.06 and 6.33%. In addition, crude fiber contents of seeds changed between 9.25 and 10.35%. Sugar compositions of fenugreek seeds changed according to locations. While fructose contents of seeds change between 1.62 and 3.06%, stachyose contents of samples ranged from 1.29 to 2.12%. While aspartic acid contents of fenugreek change between 2.65 and 3.31%, glutamic acid contents of samples were found between 3.79 and 4.82%. While linoleic acid contents of fenugreek seed oils change between 35.14 and 41.04%, linolenic acid contents of oils varied from 16.97 to 25.66%. Oleic acid contents of seed oils ranged from 11.8 to 19.93% (p < .05). Practical applications Fenugreek seeds are rich in crude protein, sugars, amino acids, and fatty acid contents. The fatty acid profile was dominated by oleic, linoleic, and linolenic acids. Fenugreek has a great medicinal value, and its seed has some medicinal properties such as hypoglycemic, laxative, stimulant, carminative, stomachic, antibacterial, antioxidant, and diuretic. However, fenugreek shows high quantities of linolenic acid (16.99–25.66%) and gets into the drying oil category. Drying oil is any of several natural oils, which oxidize to form a tough, elastic film when exposed to the air.

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Effect of Fenugreek (Trigonella foenm greacum) Seed Dietary Levels on Lipid Profile and Body Weight Gain of Rats

Cited by 11 publications

References 13 publications

Acute Toxicity and Dermal and Eye Irritation of the Aqueous and Hydroalcoholic Extracts of the Seeds of “Zapote” Pouteria mammosa (L.) Cronquist

Acute Toxicity and Dermal and Eye Irritation of the Aqueous and Hydroalcoholic Extracts of the Seeds of “Zapote” Pouteria mammosa (L.) Cronquist

Influence of Dietary Supplementation of Fenugreek (Trigonella foenum-graecum L.) on Serum Biochemical Parameters of Rats Fed High Cholesterol Diet

Effect of location on chemical properties, amino acid and fatty acid compositions of fenugreek (Trigonella foenum-graecum L.) seed and oils

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