Effect of fenugreek on hyperglycaemia and hyperlipidemia in diabetes and prediabetes: A meta-analysis

Gong, Jing; Fang, Ke; Dong, Hui; Wang, Dingkun; Hu, Menglan; Lu, Fanghong

doi:10.1016/j.jep.2016.08.003

Cited by 82 publications

(44 citation statements)

References 25 publications

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“…4-OHIle has been reported as a glucose-dependent insulinotropic compound through its direct effect on pancreatic islets and its insulin-sensitising effect on muscle, adipose and liver tissue (Figure 3). These effects, in combination with the absence of acute toxicity or genotoxicity, suggest that this amino acid has a potential role as a natural product for the treatment of obesity and IR [88,107]. …”

Section: Experimental Results Referencementioning

confidence: 99%

“…Gong et al (2016) conducted a meta-analysis regarding the overall effects of fenugreek on hyperglycaemia and hyperlipidaemia in prediabetes and diabetes. In their study, fenugreek showed hypoglycaemic effects and total cholesterol-lowering efficacy; however, the effects on TGs, LDL cholesterol, and high-density lipoprotein cholesterol (HDL-C) were not confirmed, and further studies are needed [88].…”

Section: Fenugreek (Trigonella Foenum-graecum L)mentioning

confidence: 99%

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4-Hydroxyisoleucine from Fenugreek (Trigonella foenum-graecum): Effects on Insulin Resistance Associated with Obesity

Avalos-Soriano

Cruz-Cordero²,

Rosado

et al. 2016

Molecules

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Obesity and insulin resistance (IR) are interdependent multifactorial processes that cannot be understood separately. Obesity leads to systemic inflammation and increased levels of free fatty acids that provoke IR and lipotoxicity. At the same time, IR exacerbates adipose cell dysfunction, resulting in chronic inflammation and major lipotoxic effects on nonadipose tissues. 4-Hydroxyisoleucine (4-OHIle), a peculiar nonprotein amino acid isolated from fenugreek (Trigonella foenum-graecum) seeds, exhibits interesting effects on IR related to obesity. 4-OHIle increases glucose-induced insulin release, and the insulin response mediated by 4-OHIle depends on glucose concentration. The beneficial effects observed are related to the regulation of blood glucose, plasma triglycerides, total cholesterol, free fatty acid levels, and the improvement of liver function. The mechanism of action is related to increased Akt phosphorylation and reduced activation of Jun N-terminal kinase (JNK)1/2, extracellular signal-regulated kinase (ERK)1/2, p38 mitogen-activated protein kinase (MAPK), and nuclear factor (NF)-κB. Here, we present a review of the research regarding the insulinotropic and insulin-sensitising activity of 4-OHIle in in vitro and in vivo models.

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Section: Experimental Results Referencementioning

confidence: 99%

Section: Fenugreek (Trigonella Foenum-graecum L)mentioning

confidence: 99%

4-Hydroxyisoleucine from Fenugreek (Trigonella foenum-graecum): Effects on Insulin Resistance Associated with Obesity

Avalos-Soriano

Cruz-Cordero²,

Rosado

et al. 2016

Molecules

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“…A meta‐analysis previously investigated the effect of fenugreek on lipid profile but only in T2DM patients (Gong et al, 2016). To the best of our knowledge this is the first meta‐analysis about the effect of Trigonella foenum‐graecum (fenugreek) on lipid profile (total cholesterol [TC], high‐density lipoprotein cholesterol [HDL‐C], low‐density lipoprotein cholesterol [LDL‐C], and TGs) in patients with Type 2 diabetes, healthy volunteers, and hyperlipidemic patients both as a group and as a whole.…”

Section: Introductionmentioning

confidence: 99%

Effect of fenugreek consumption on serum lipid profile: A systematic review and meta‐analysis

Heshmat-Ghahdarijani

Mashayekhiasl

Amerizadeh

et al. 2020

Phytotherapy Research

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Various studies have shown that Trigonella foenum‐graecum (fenugreek) supplementation has lipid‐lowering activity. This meta‐analysis was performed to evaluate the effect of fenugreek supplementation on human serum lipid profile. Data sources were PubMed, EMBASE, Scopus, and Coherence library which were searched systematically from January 2000 up to December 2019. Inclusion criteria were randomized clinical trial (RCT) study design, at least one of lipid profile components (triglyceride [TG], total cholesterol [TC], low‐density lipoprotein cholesterol, and high‐density lipoprotein cholesterol) levels measured before fenugreek use and one of the lipid components level reported as result. The pooled weighted mean difference (MD) and its 95% confidence interval (CI) were calculated and pooled using a random‐effect model. Only articles published in English were considered. Fifteen RCTs involving 281 cases consumed fenugreek and 255 control cases in controlled group (11 articles) and 136 cases in uncontrolled group (4 articles) were analyzed in our study. Pooled data of indicated a significant impact of fenugreek supplementation on lowering TC (−1.13 [−1.88, −0.37]; p = .003), low‐density lipoprotein (LDL) (−1.26 [−2.09, −0.43]; p = .003), and TG (−1.07 [−1.82, −0.33]; p = 0.005) and increasing the high‐density lipoprotein (HDL) level (0.70 [0.07, 1.34]; p = .03) compared with the control group. There were no significant differences in TC, TG, and LDL between pre‐ and post‐fenugreek studies in the noncontrolled studies however, the result of combination of four studies without control group showed a significant increase in mean HDL (0.81 [0.33,1.29]; p‐value = .001). The results of subgroup analysis showed that the fenugreek reduced the TG and LDL and increases HDL levels in diabetic subjects more effectively. Fenugreek supplementation significantly improved lipid profile (LDL, TG, TC, and HDL). It could be considered as an effective lipid‐lowering medicinal plant. Further high‐quality studies are needed to firmly establish the clinical efficacy of the plant.

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“…Over 300,000,000 individuals have type-2 diabetes mellitus (T2dM) worldwide (1). T2dM magnifies the morbidity and mortality rates of cardiovascular diseases, including neuropathy, retinopathy and peripheral artery disease (2).…”

Section: Introductionmentioning

confidence: 99%

Upregulated 14‑3‑3β aggravates restenosis by promoting cell migration following vascular injury in diabetic rats with elevated levels of free fatty acids

et al. 2018

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Mono‑unsaturated free fatty acids (FFAs) can serve as a predictive indicator of vascular restenosis following interventional therapy, particularly in individuals with high‑fat diet‑induced type 2 diabetes. However, the pathogenic mechanism remains to be fully elucidated. In the present study, the levels of tyrosine 3‑monooxygenase/tryptophan 5‑monooxygenase activation protein β (YWHAB; also known as 14‑3‑3β), in vascular smooth muscle cells (VSMCs) treated with different concentrations of oleic acid (OA) were examined by reverse transcription‑quantitative polymerase chain reaction and western blot analyses. The migration of VSMCs was examined using wound‑healing and Transwell migration assays. The protein distribution of B‑cell lymphoma 2 (BCL‑2)‑associated death promoter (BAD) in VSMCs treated with OA was examined by immunofluorescence and western blot analyses. In in vivo experiments, the carotid artery morphology of rats in different groups was assessed at 14 days post‑injury by non-invasive ultrasonographic imaging and confirmed by histological staining. The expression of YWHAB was upregulated by OA in a concentration‑dependent manner in VSMCs. In the in vivo experiments, carotid stenosis was more serious among high‑FFA diabetic rats. However, silencing of YWHAB significantly alleviated carotid neointimal hyperplasia among the diabetic rats with elevated FFA levels. In addition, YWHAB silencing alleviated the migration of OA‑treated VSMCs and increased translocation of the BAD protein from the cytoplasm to the mitochondria. In conclusion, the results showed that FFA‑induced upregulation of YWHAB was involved in neointimal hyperplasia by enhancing the migration of VSMCs following carotid artery injury. The inhibition of YWHAB may serve as a novel potential pharmacological target for preventing vascular restenosis following interventional therapy in diabetic individuals with high FFA levels.

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Effect of fenugreek on hyperglycaemia and hyperlipidemia in diabetes and prediabetes: A meta-analysis

Cited by 82 publications

References 25 publications

4-Hydroxyisoleucine from Fenugreek (Trigonella foenum-graecum): Effects on Insulin Resistance Associated with Obesity

4-Hydroxyisoleucine from Fenugreek (Trigonella foenum-graecum): Effects on Insulin Resistance Associated with Obesity

Effect of fenugreek consumption on serum lipid profile: A systematic review and meta‐analysis

Upregulated 14‑3‑3β aggravates restenosis by promoting cell migration following vascular injury in diabetic rats with elevated levels of free fatty acids

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