Effect of feeding a choline-deficient diet on the hepatic nuclear response to tryptophan in the rat

Sidransky, Herschel; Verney, Ethel; Kurl, Rabinder N.

doi:10.1016/0014-4800(89)90008-7

Cited by 5 publications

(1 citation statement)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Arginine, alanine, and glycine were associated with a hypocholesterolemic effect in humans, rats, and rabbits (38,71,72), and in our studies, these amino acids had moderate but consistent inhibitory effects on apoB100 secretion. Strikingly, a number of amino acids that we found to be the most potent in our in vitro cell studies have also been shown to have hypocholesterolemic effects in in vivo human and animal studies, including tryptophan (73,74), glutamic acid (75)(76)(77), cysteine, and methionine (78 -83).…”

Section: Discussionmentioning

confidence: 88%

The Effect of Individual Amino Acids on ApoB100 and Lp(a) Secretion by HepG2 Cells

Cianflone

Zu-jun

et al. 1996

Journal of Biological Chemistry

View full text Add to dashboard Cite

p16(INK4) is a specific cyclin D-dependent kinase inhibitor and a multiple tumor suppressor. Inactivation of p16 is frequent in both primary tumors and tumor-derived cell lines. We describe here the conformational properties and oligomerization state of seven mutant p16 proteins; all of them are deficient in function. Four of the seven proteins show significantly disrupted secondary structure and backbone folding. The other three adopt partially folded, molten globule-like conformations. These proteins have near-native levels of secondary structure, but lack the ability to undergo a cooperative thermal transition and are substantially less resistant to proteolysis than is wild type p16. At low concentrations, two of the seven proteins are monomers, three exhibit an apparent molecular weight between the value of a monomer and a dimer, and the other two aggregate significantly. Our results strongly suggest that defective protein folding and/or aggregation is a common mechanism for inactivation of p16.

show abstract

Section: Discussionmentioning

confidence: 88%

The Effect of Individual Amino Acids on ApoB100 and Lp(a) Secretion by HepG2 Cells

Cianflone

Zu-jun

et al. 1996

Journal of Biological Chemistry

View full text Add to dashboard Cite

show abstract

Effects of vitamins on hepatic nuclear binding of L-tryptophan

Sidransky

Verney

2001

Amino Acids

View full text Add to dashboard Cite

This study investigated the in vitro effects of selected vitamins on nuclear L-tryptophan receptor binding of rat liver. Our results revealed that some fat-soluble vitamins, beta-carotene, retinyl acetate, calciferol, alpha-tocopherol, and Trolox, as well as some water-soluble vitamins, thiamine and riboflavin, acted to inhibit in vitro 3H-tryptophan binding to hepatic nuclei. On the other hand, pyridoxine had little or no effect. The addition of dithiothreitol, a protective agent for sulfhydryl groups, along with each vitamin decreased the vitamin's inhibitory effect on in vitro 3H-tryptophan binding to nuclei, with the exception of riboflavin and calciferol. The addition of L-leucine, which alone had no inhibitory effect on in vitro 3H-tryptophan binding to hepatic nuclei but when added with unlabeled L-tryptophan negated the effect of unlabeled L-tryptophan, caused a markedly diminished inhibitory binding effect due to each of the following vitamins, thiamine, beta-carotene, retinyl acetate, and alpha-tocopherol and Trolox, but no effect on riboflavin and calciferol.

show abstract

Tryptophan and carcinogenesis: Review and update on how tryptophan may act

Sidransky

1997

Nutrition and Cancer

View full text Add to dashboard Cite

This review covers the historical developments of the consideration that tryptophan may influence the induction of cancer in experimental studies. Studies relating to stimulatory effects, as well as to inhibitory effects, of tryptophan or tryptophan-related compounds are described. Also the effects of pyrolysis products of tryptophan on carcinogenesis are covered. In consideration that new L-tryptophan-related contaminants may be involved in a recently described human disease, a description is given of the eosinophilia-myalgia syndrome, which has been attributed to the ingestion of L-tryptophan-containing related contaminants. Whether these new L-tryptophan-related contaminants alone or together with L-tryptophan may prove to be carcinogenic remains to be determined. Lastly, recent developments relating to regulatory effects of L-tryptophan on liver metabolism are reviewed and then considered as possibly playing a role in carcinogenesis.

show abstract

Effect of feeding a choline-deficient diet on the hepatic nuclear response to tryptophan in the rat

Cited by 5 publications

References 30 publications

The Effect of Individual Amino Acids on ApoB100 and Lp(a) Secretion by HepG2 Cells

The Effect of Individual Amino Acids on ApoB100 and Lp(a) Secretion by HepG2 Cells

Effects of vitamins on hepatic nuclear binding of L-tryptophan

Tryptophan and carcinogenesis: Review and update on how tryptophan may act

Contact Info

Product

Resources

About