Effect of Fe and Cd Co-Exposure on Testicular Steroid Metabolism, Morphometry, and Spermatogenesis in Mice

Wokoma, Adaba F S; Mgbudom-Okah, Chidimma J; Omeodu, S.I.; Ohanador, Robinson

doi:10.1007/s12011-018-1536-2

Cited by 28 publications

(23 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…and oral Cd exposure. Differently, mice receiving 25 mg/kg of CdCl 2 , once a week for 35 days, showed a reduction in testicular Fe concentration [39]. In another study, these authors also observed reduction in this mineral in animals receiving 50 mg/kg of CdCl 2 once a week for 60 days [40].…”

Section: Discussionmentioning

confidence: 99%

Subacute Testicular Toxicity to Cadmium Exposure Intraperitoneally and Orally

Mouro

Martins

Silva

et al. 2019

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

The toxic effects of cadmium (Cd) on reproductive parameters are widely described in the literature. Experimental models often make use of the intraperitoneal route (i.p.), although human intoxication occurs preferentially by the oral route and can be continuous. However, little is known about the effect of Cd administration routes on the testicular structure. Thus, this study investigated the testicular impact of Cd exposure comparing both i.p. and oral routes, both single dose (SD), in addition to the oral route in fractional doses (FD). Swiss adult male mice received CdCl2 1.5 mg/kg i.p., 30 mg/kg oral SD, and 4.28 mg/kg oral FD for 7 consecutive days. The Cd bioaccumulation was observed in all routes, mainly in the oral FD route. The concentrations of testicular Ca and Cu decreased in all animals exposed to Cd, while Zn and Mn decreased only in the i.p. route. Testicular SOD activity was reduced in both routes of oral administration, while CAT increased in the i.p. route, and GST increased in all animals exposed to Cd. Changes in the tubular parameters and cell viability were observed in both routes of Cd administration but were more intense in the oral route, mainly in the FD. Serum testosterone concentration was reduced in both routes of oral administration. Tubular damage, such as the vacuolization of the seminiferous epithelium, germ cell detachment, and seminiferous tubule degeneration, occurred in all groups exposed to Cd. Therefore, the oral Cd administration presented greater potential to promote testicular damage, mainly when the metal was given in a fractionated way.

show abstract

Section: Discussionmentioning

confidence: 99%

Subacute Testicular Toxicity to Cadmium Exposure Intraperitoneally and Orally

Mouro

Martins

Silva

et al. 2019

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

show abstract

“…Ten transverse seminiferous tubules sections which were round or nearly round shape were randomly chosen from each animal. The measurement was performed according to previous studies 28 …”

Section: Methodsmentioning

confidence: 99%

Protective effects of ethyl acetate extract from Shorea roxburghii against diabetes induced testicular damage in rats

Zhao

Olatunji

2020

Environmental Toxicology

View full text Add to dashboard Cite

Diabetic mellitus is a chronic metabolic disorder that is associated with several complications including testicular dysfunction. This research investigated the protective action of the ethyl acetate extract from Shorea roxburghii (SRE) on diabetes induced testicular damage in rats. Diabetic rats were orally administered with SRE at doses of 100 and 400 mg/kg for 4 weeks. SRE improved the body weight gain, testes weight, testes index and increased serum concentration of testosterone. Furthermore, SRE increased the testicular antioxidant enzymes including superoxide dismutase, catalase and glutathione peroxidase. In addition, SRE ameliorated testicular inflammatory mediators such as myeloperoxidase, tumor necrosis factor alpha, interleukin 6, p38 MAPK and nuclear factor kappa B activation and decreased testicular cell apoptosis in the treated diabetic rats. SRE also raised sperm parameters after treatment of diabetic rats. Conclusively, our results suggested that SRE ameliorated diabetes induced testicular damage by inhibiting oxidative stress and inflammation.

show abstract

“…Cadmium (Cd) is an environmentally abundant toxic heavy metal (Abarikwu et al, 2018;Fan et al, 2018;Zhang et al, 2018). Food and cigarettes are two major sources of human exposure to Cd (Mannino et al, 2004;Ivanova et al, 2017); however, higher levels of exposure to Cd may be seen in occupational settings, such as nickel-cadmium battery manufacturing enterprises.…”

Section: Introductionmentioning

confidence: 99%

Hyperglycemia exacerbates cadmium-induced glomerular nephrosis

Liu

Zhang

2021

Toxicol Ind Health

View full text Add to dashboard Cite

Current research suggests that cadmium (Cd) exposure may be associated with the progression of diabetic nephropathy; however, the details of this relationship are insufficiently understood. The present study investigated the effects of elevated glucose on Cd-induced toxicity to glomerular cells using in vitro and in vivo models, and it demonstrated that Cd exposure and the hyperglycemia of diabetes acting together increased the risk of developing glomerular nephrosis . In vitro, human podocytes were exposed to a DMEM low-glucose media without (control), or with Cd (as CdCl2), or a high-glucose media plus Cd. The CCK-8, ROS, apoptosis, and mitochondrial transmembrane potential (ΔΨm) assays showed that human podocytes exposed to Cd in a high-glucose media had greater degrees of injury compared with cells treated with Cd at low (euglycemic)-glucose levels. In vivo, diabetic hyperglycemia was induced by streptozotocin in 8-week-old male C57BL/6 mice to which either CdCl2 or saline (control) was intraperitoneally injected twice weekly for 24 weeks. Compared with euglycemic saline-treated controls, the diabetic mice exposed to Cd demonstrated decreased body weight and increased blood urea nitrogen levels along with histopathological renal architecture changes including collagen fiber accumulation. The results of this study supported the hypothesis that hyperglycemia plus Cd exposure increases the risk of damage to glomerular podocytes compared with Cd exposure in euglycemia.

show abstract

Effect of Fe and Cd Co-Exposure on Testicular Steroid Metabolism, Morphometry, and Spermatogenesis in Mice

Cited by 28 publications

References 58 publications

Subacute Testicular Toxicity to Cadmium Exposure Intraperitoneally and Orally

Subacute Testicular Toxicity to Cadmium Exposure Intraperitoneally and Orally

Protective effects of ethyl acetate extract from Shorea roxburghii against diabetes induced testicular damage in rats

Hyperglycemia exacerbates cadmium-induced glomerular nephrosis

Contact Info

Product

Resources

About