Effect of Fasciola gigantica infection on adrenal and thyroid glands of riverine buffaloes

Ganga, G.; Varshney, J. P.; Sharma, Rinku; Varshney, Vaibhav Kumar; Kalicharan,

doi:10.1016/j.rvsc.2006.04.002

Cited by 8 publications

(9 citation statements)

References 5 publications

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“…The Murrah buffalo yearlings, infected with 800/1000 F. gigantica MC, persistently had elevated hormone activity in the circulation indicated variable degree and magnitude of the adrenocortical response to the in situ distome population (Ganga et al 2007;Edith et al 2010c). The response was, however, variable in severity depending upon the clinical phase of the disease, in situ activities and location of the F. gigantica adolescercariae or adult fluke population.…”

Section: Adrenal Glandsmentioning

confidence: 99%

“…In large ruminants, including buffalo, anaemia and hypoalbuminaemia are being the most common and glaring manifestations, consistent of the fasciolosis (Kumar et al 1982;Ganga et al 2007;Edith et al 2010b). The developing F. gigantica juveniles and the adults have been considered non-haematophagous and tissue feeding parasites yet cause severe anaemia in the host suffering from acute and/or chronic disease (Ganga et al 2004b).…”

Section: Anaemiamentioning

confidence: 99%

“…Various factors, such as haematophagia, haemorrhages during migratory phase and injurious nature of the fluke metabolites discharged into the host circulation significantly contribute to the development of anaemia (Ganga et al 2004a). Buffalo calves, suffering from the acute course of the disease, with mean fluke load of 300 and above had a significant fall in erythrocytic indices during late prepatency caused normocytic normochromic anaemia (Yadav et al 1999b;Ganga et al 2007), whereas in the chronic phase, hypoalbumineamia is more marked than anaemia and an immune carrier host, on partial recovery from the acute course of the disease, continues to suffer from normocytic hypochromic anaemia (Edith et al 2010b). …”

Section: Anaemiamentioning

confidence: 99%

“…It was strongly speculated that the fluke metabolites discharged into the circulation coupled with generalized oxygen starvation at tissue level, incidental to the severe and prolonged anaemia could influence normal functioning of the hypothalamus-pituitary axis and consequently, the altered physiological plasma levels of the tropic hormones leading to dysfunctioning of the target endocrine gland(s), especially thyroid and adrenal glands that influence and shift the entire metabolism in the host (Ganga et al 2007;Edith et al 2010a, c).…”

Section: Endocrine Gland Dysfunctionmentioning

confidence: 99%

“…The histopathological evidences of hypothyroidism in the diseased host were appearance of peripheral vacuoles and atrophy of the thyroid follicles and lymphocytic thyroiditis with diffuse mononuclear cell infiltration in inter and intracellular spaces, causing progressive destruction of thyroid hormone secretory cells and follicles. Even though the infected buffaloes did not show classical clinical signs of hypothyroidism, such as obesity and myxoedema yet lower concentrations of T 3 and T 4 in host circulation indicated a clear picture of non-clinical hypothyroidism (Ganga et al 2003(Ganga et al , 2007.…”

Section: Thyroid Glandmentioning

confidence: 99%

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Epizootiology, pathogenesis and immunoprophylactic trends to control tropical bubaline fasciolosis: an overview

Sharma¹,

Godara²,

Thilagar³

2011

J Parasit Dis

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On the Indian sub-continent, nearly 5,000 years ago, the domestication of the riverine buffalo-the incredible Asian dairy animal was initiated. It plays a versatile role in socio-economic upliftment of its owners from the rural agricultural communities in Asian, African, South American and a few European countries. Comparatively, buffaloes are lesser evolved and susceptible to infectious diseases than cattle. However, poor body thermoregulation and wallowing nature predisposed them to snail borne infections, especially tropical fasciolosis-an incessant major constraint on buffalo production and improvement programmes. This review article is an insight into the global prevalence, varied epizootiological factors, offers possible explanation to pathophysiological clinical signs, deleterious effects of the tropical liver fluke, involving hepato-biliary system, haemopoitic system, endocrine glands and their secretions, oxidative stress, altered metabolism and significant fall in food conversion efficiency with unaffected digestibility of nutrients. Besides, the authors have briefly discussed and reviewed the developments and significance of successful immunodiagnostic approaches for detecting and forecasting the disease during early pre-patency and feasibility of developing a cost effective immunoprotection strategies against tropical fasciolosis.

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Section: Adrenal Glandsmentioning

confidence: 99%