Effect of fangchinoline on root resorption during rat orthodontic tooth movement

Bao, Xingfu; Hu, Min; Zhang, Yi; Machibya, Ferdinand Mabula; Zhang, Ying; Jiang, Huan; Yu, Dongsheng

doi:10.4041/kjod.2012.42.3.138

Cited by 10 publications

(6 citation statements)

References 19 publications

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“…What is more, cementogenesis has been well accepted as a target to alleviate root resorption currently. Thereby, various studies have been carried out to enhance the cementogenesis process [ 11 – 13 ].…”

Section: Introductionmentioning

confidence: 99%

Strontium Promotes Cementoblasts Differentiation through Inhibiting Sclerostin ExpressionIn Vitro

Bao

Liu

Zhang

et al. 2014

BioMed Research International

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Cementogenesis, performed by cementoblasts, is important for the repair of root resorption caused by orthodontic treatment. Based on recent studies, strontium has been applied for osteoporosis treatment due to its positive effect on osteoblasts. Although promising, the effect of strontium on cementoblasts is still unclear. So the aim of this research was to clarify and investigate the effect of strontium on cementogenesis via employing cementoblasts as model. A series of experiments including MTT, alkaline phosphatase activity, gene analysis, alizarin red staining, and western blot were carried out to evaluate the proliferation and differentiation of cementoblasts. In addition, expression of sclerostin was checked to analyze the possible mechanism. Our results show that strontium inhibits the proliferation of cementoblasts with a dose dependent manner; however, it can promote the differentiation of cementoblasts via downregulating sclerostin expression. Taking together, strontium may facilitate cementogenesis and benefit the treatment of root resorption at a low dose.

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Section: Introductionmentioning

confidence: 99%

Strontium Promotes Cementoblasts Differentiation through Inhibiting Sclerostin ExpressionIn Vitro

Bao

Liu

Zhang

et al. 2014

BioMed Research International

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“… 8 , 19 , 20 The OMs group comprised 13 articles of which seven were rejected because the via of administration was intragastric (five cases), 21 - 25 intraperitoneal (one case), 26 or intramuscular, 27 and one due to the small size of the experimental groups. 28 …”

Section: Resultsmentioning

confidence: 99%

Experimental evidence of pharmacological management of anchorage in Orthodontics: A systematic review

Fernández-González

Cañigral

Balbontin-Ayala

et al. 2015

Dental Press J. Orthod.

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Introduction: Orthodontic anchorage is one of the most challenging aspects of Orthodontics. Preventing undesired movement of teeth could result in safer and less complicated orthodontic treatment. Recently, several reviews have been published about the effects of different molecules on bone physiology and the clinical side effects in Orthodontics. However, the effects of local application of these substances on the rate of orthodontic tooth movement have not been assessed. Objectives: The aim of this research was to analyze the scientific evidence published in the literature about the effects of different molecules on orthodontic anchorage. Methods: The literature was systematically reviewed using PubMed/Medline, Scopus and Cochrane databases from 2000 up to July 31st, 2014. Articles were independently selected by two different researchers based on previously established inclusion and exclusion criteria, with a concordance Kappa index of 0.86. The methodological quality of the reviewed papers was performed.Results: Search strategy identified 270 articles. Twenty-five of them were selected after application of inclusion/exclusion criteria, and only 11 qualified for final analysis. Molecules involved in orthodontic anchorage were divided into three main groups: osteoprotegerin (OPG), bisphosphonates (BPs) and other molecules (OMs). Conclusions: Different drugs are able to alter the bone remodeling cycle, influencing osteoclast function and, therefore, tooth movement. Thus, they could be used in order to provide maximal anchorage while preventing undesired movements. OPG was found the most effective molecule in blocking the action of osteoclasts, thereby reducing undesired movements.

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“…These results are consistent with those of other studies finding that an increase in the magnitude of the applied force aggravates root resorption and periodontal destruction. The resorption lacunae can be detected on the alveolar bone and root from 3 to 28 d and longer after tooth movement . In this study, 50‐ and 100‐g forces, which are heavy forces for rats , were applied for 7 d to induce movement of the M1 and cause damage to the periodontal tissue in our model.…”

Section: Discussionmentioning

confidence: 99%

Stress overload‐induced periodontal remodelling coupled with changes in high mobility group protein B1 during tooth movement: an in‐vivo study

Zou

Lin

2019

European J Oral Sciences

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High mobility group protein B1 (HMGB1), a bone‐active cytokine and an osteocyte alarmin, might have dual functions in bone metabolism that could benefit bone formation and accelerate osteoclastogenic activity. High mobility group protein B1 was recently shown to be involved in tooth movement. Here, we investigated the expression of HMGB1, which remains poorly elucidated, under stress overload‐induced periodontal remodelling conditions in vivo. Thirty‐six Sprague‐Dawley rats (male, 180–200 g) were randomly divided into three groups: two experimental groups, in which 50 or 100 g of force was applied to the first molars for 7 d to induce movement; and one control group, in which no force was applied. These stresses induced tooth movement over significantly different distances, and marked morphological changes were consistently observed in the periodontal tissues of the experimental rats, as demonstrated by histological staining. A real‐time PCR analysis showed upregulation of the receptor activator of nuclear factor‐kappaB ligand‐to‐osteoprotegerin ratio and downregulation of the Hmgb1 gene. Changes in both location and expression of the HMGB1 were observed through immunofluorescence analysis. Our data suggest that HMGB1 expression during orthodontic tooth movement might be regulated in a time‐ and force‐dependent manner that is substantially more complex than anticipated.

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Effect of fangchinoline on root resorption during rat orthodontic tooth movement

Cited by 10 publications

References 19 publications

Strontium Promotes Cementoblasts Differentiation through Inhibiting Sclerostin ExpressionIn Vitro

Strontium Promotes Cementoblasts Differentiation through Inhibiting Sclerostin ExpressionIn Vitro

Experimental evidence of pharmacological management of anchorage in Orthodontics: A systematic review

Stress overload‐induced periodontal remodelling coupled with changes in high mobility group protein B1 during tooth movement: an in‐vivo study

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