Purpose – Prosthetic results are largely dominated by physical and mechanical properties of materials used. This
systematic review aims to identify and interpret results of studies that evaluated effect of disinfection on physical
properties of maxillofacial silicone elastomers. Search for all articles regarding the topic, written Method – in English
language only, before December 2021 was carried out using electronic search in PubMed, Google Scholar and Scopus.
Also a manual search in all major Prosthodontic, Research and Biomaterial journals was carried out. A Results – fter
initial search, screening and final selection, 28 studies were selected for review based on inclusion-exclusion criteria.
Among the studies selected only 1 study was published before year 2000 describing the influence of disinfectant on
physical properties of maxillofacial silicone elastomer. Though 27 studies have been published in the period between
2008 to 2021, depicting the change of trend in research in maxillofacial prosthodontics. Disinfectio Conclusion- n
influence various physical properties of maxillofacial silicone elastomer. Currently no ideal silicone material is
available for prosthetic rehabilitation. So there is a need for more search and research to develop a successful
maxillofacial silicone elastomer. Also the literature describing selection of disinfectant and protocol for disinfection of
silicone is highly variable. Hence the standardization organisations or scientific community must design a standard
protocol for disinfection procedure to improve longevity of silicone prosthesis and health of surrounding natural tissues.