Effect of Extracorporal Hemosorption on Elimination of Antibacterial Drugs in Sepsis

Abstract

Background. Sepsis and septic shock make a significant proportion of the causes of death in intensive care units. Hemosorption in combination with standard sepsis therapy reduces mortality by an average of 5-7% and significantly lowers the need for vasopressor support. Purpose of the study. Our aim is to investigate the data available about the effect of hemosorption on the dynamics of antibiotic levels in the blood plasma of patients. Material and methods. The results of more than 20 studies of the efficacy of various hemosorbents in the treatment of sepsis were analyzed. Results. Data on the significant effect of CytoSorb and Toraymyxin B sorbents on the pharmacokinetics of a number of antibiotics have been obtained. There are no data on the Belarusian sorbents Proteasosorb and LPS-hemo. Conclusions. The degree of elimination of antibacterial drugs during hemosorption depends on the specific characteristics of each sorbent. All potential adverse effects need to be carefully studied to maximize the use of hemosorption in the treatment of sepsis.