Effect of exogenous progesterone and oestradiol on plasma progesterone concentrations and follicle wave dynamics in anovulatory anoestrous post-partum dairy cattle

McDougall, S; Compton, C.W.R.; Anniss, F.M.

doi:10.1016/j.anireprosci.2004.02.009

Cited by 15 publications

(8 citation statements)

References 29 publications

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“…The inclusion of two CIDR inserts had improved the conception rate in cows that had no CL at the start of the CIDR-Ovsynch treatment [46]. However, two other studies reported that using two or three progesterone-releasing inserts did not improve the P/AI compared with one treatment [47,48]. In the current study, the new and the reused CIDR inserts induced similar serum progesterone concentration at 3 h, 3 days, and 7 days post insertion.…”

Section: Discussioncontrasting

confidence: 44%

Efficacy of ovulation synchronization with timed artificial insemination in treatment of follicular cysts in dairy cows

2020

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Section: Discussioncontrasting

confidence: 44%

Efficacy of ovulation synchronization with timed artificial insemination in treatment of follicular cysts in dairy cows

2020

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“…Determination of the impact of supplemental progesterone in cows at risk of anovulation can be measured both as short-term and long-term effects. Intravaginal treatment of anovulatory anestrus cows with 1.56 g of progesterone has been reported to increase circulating progesterone concentrations to a peak of 1.2 ng/mL within 24 h and maintain an average serum P4 concentration greater than 1 ng/mL for 7 d (McDougall et al, 2004). Variability in the observed increase in circulating progesterone concentrations can be quite large (Darwash et al, 2001) and is influenced by feed intake and milk production (Lopez et al, 2004;Wiltbank et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

Synchronization of Estrus and Pregnancy Risk in Anestrous Dairy Cows After Treatment with a Progesterone-Releasing Intravaginal Device

Walsh

LeBlanc

Duffield

et al. 2007

Journal of Dairy Science

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Lactating Holstein cows (located in 4 dairy herds) that had failed to display estrus as defined by increased pedometer activity by 63 +/- 3 d in milk, were enrolled to investigate the effect of a progesterone-releasing intravaginal device (PRID, n = 268) relative to a placebo intravaginal device (PID, control, n = 266) on days from device removal to artificial insemination (AI), the probability of pregnancy at first AI, and days from device removal to pregnancy. Cows were assigned randomly to receive a PRID or PID for 7 d and an injection of PGF2alpha at device removal. Upon device removal, a vaginitis score was assigned and AI occurred at observed estrus. Cows failing to display estrus within 14 d of device removal were subjected to a subsequent reproductive exam and were treated with PGF2alpha. Two percent of PRID-treated cows and 11% of control cows displayed estrus during the 7-d exposure period. Among the remaining cows, 93% of the devices were present at the scheduled removal. Cows treated with the PRID were 60% less likely to have purulent debris on the device than control cows. Vaginal reaction, however, was not associated with any of the reproductive outcomes. Investigation of the reproductive outcomes revealed a treatment x parity interaction. Progesterone-treated primiparous cows were inseminated 17 d earlier, with no significant change in the probability of pregnancy at first AI (30.3 vs. 42.0%), and no difference in median time from device removal to pregnancy (52 vs. 53 d) relative to control primiparous cows. Conversely, PRID-treated multiparous cows were inseminated 8 d earlier, with no change in probability of pregnancy at first AI (24.6 vs. 18.8%); however, median time from device removal to pregnancy was reduced by 20 d (67 vs. 87 d). These results support the efficacy of a PRID to induce estrus in previously anestrous cows. The reason, however, for the variable response between primiparous and multiparous cows was not clear.

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“…To minimize this negative effect protocols aiming to synchronize estrus and the use of TAI allow ovulation induction without the occurrence of estrus manifestation are important tools to increase reproductive performance [22]. The exogenous estradiol administered together with progesterone causes the dominant follicle atresia when administered before or during emergence of the wave suppressing FSH and LH [15]. According the results from the present experiment, conception rates are not affected by using either EB or GnRH at the beginning of the Heatsynch protocol.…”

Section: Discussionmentioning

confidence: 46%

“…When administered together with a progestin, estradiol causes atresia of the dominant follicle, initiating the emergence of a new follicular wave [15] since the GnRH promotes ovulation of the dominant follicle and the beginning of a new follicular wave [2].…”

Section: Introductionmentioning

confidence: 99%

Effect of GnRH or Estradiol Benzoate on Reproductive Traits during a Heatsynch Protocol in Dairy Cows

Mielke¹,

Rodrigues

Lima

et al. 2016

Acta Scientiae. Vet.

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Background: Milk production of cows is closely correlated with its reproductive efficiency. One of the several factors influencing the dairy efficiency is the decline in fertility of the cows/heifers. Use of hormonal protocol are often used to improve the fertility of the recipients. Several programs are available to inseminate dairy cows, with variation in the use of different types of hormones, time of use and range of duration period, as well as the time of AI. The objective of this study was to evaluate the efficiency of follicular wave emergence induction of estradiol benzoate in comparison to GnRH in a Heatsynch protocol and its influence on reproductive parameters.Materials, Methods & Results: In this study were used primiparous and multiparous Holstein cows (n = 325). Animals were divided randomly into two different treatments according with the hormone used to induce follicular wave emergence (D0). The GnRH group (n = 167), was given 25 mg, while in the EB group (n = 158) was used 2 mg. At same day, were inserted, a controlled internal drug-releasing containing 1.9 g of progesterone CIDR®. On day 7, CIDR was removed and cows were given 25 mg luteinizing hormone followed by an injection of 1 mg Inducer Ovulation at day 8. Cows were then observed for signs of estrus for at least two hours (twice daily at 7 am and 6 pm) for three days following CIDR® removal. Cows detected in estrus were inseminated 12 h later the estrus detection. Pregnancy status was determined by ultrasonography at 30 ± 5 d and 60 ± 5 d after AI. A single technician was responsible for the estrus detection and inseminations. A single technician was responsible for the estrus detection and inseminations. Ultrassonographic examinations with ultrasound, transrectal linear probe of 5 MHz, were performed for the diagnosis of pregnancy at 30 and 60 days after artificial insemination. Binomially distributed data, such as, estrous response, conception rate, pregnancy rate and pregnancy losses, were analyzed by Chi-square test. Pregnancy rates at 30-35 days and 60-65 days as well as pregnancy losses were considered in the model for the effect of parity (primiparous vs. multiparous) and the group of estrus behavior during the Heatsynch protocol. Conception rate was similar between GnRH (36.1%, 57/158) and EB (37.7%, 63/167) treatments. Cows showing estrus signs after CIDR removed were 71.9% in GnRH and 62% in EB group (P = 0.05). Embryonic losses were different (P = 0.03) according to groups of cows showing estrus signals or not.Discussion: Our results demonstrate that conception rates are not affected by using either EB or GnRH at the beginning of the Heatsynch protocol. Therefore, the EB can be an alternative choice to GnRH at Heatsynch beginning. Similar results were found by autor in dairy cows, once it was also observed that there is no difference in conception rate in two TAI protocols using either GnRH or EB. In Heatsynch protocols the increase in estrus detection are a key factor to increase fertility in lactating dairy cows. It can be explained once animals in regular estrous cycle have a palpable corpus luteum and circulating progesterone concentration higher than 1 ng/mL which leads than to enhance pregnancy ratios. The use of BE at the time of CIDR insertion in TAI protocols for dairy cattle proved to be an alternative to GnRH considering conception rates. Therefore, the use of BE at the time of CIDR insertion in a Heatsynch protocol in dairy cattle proved to be an alternative to GnRH which can be an important tool to increase the TAI utilization by farmers. Furthermore, in Heatsynch protocol cows showing estrus have pregnancy rates improved and lower pregnancy losses.

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Effect of exogenous progesterone and oestradiol on plasma progesterone concentrations and follicle wave dynamics in anovulatory anoestrous post-partum dairy cattle

Cited by 15 publications

References 29 publications

Efficacy of ovulation synchronization with timed artificial insemination in treatment of follicular cysts in dairy cows

Efficacy of ovulation synchronization with timed artificial insemination in treatment of follicular cysts in dairy cows

Synchronization of Estrus and Pregnancy Risk in Anestrous Dairy Cows After Treatment with a Progesterone-Releasing Intravaginal Device

Effect of GnRH or Estradiol Benzoate on Reproductive Traits during a Heatsynch Protocol in Dairy Cows

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