Effect of exogenous melatonin on embryo viability and uterine environment in undernourished ewes

Vázquez, M.I.; Forcada, F.; Sosa, Cecilia; Casao, A.; Sartore, I.; Fernández-Foren, A.; Meikle, A.; Abecia, J. A.

doi:10.1016/j.anireprosci.2013.07.007

Cited by 13 publications

(9 citation statements)

References 49 publications

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“…On the other hand, melatonin decreases ERα expression in the deep stroma of ewes. The E 2 -ERα complex acts as a luteolytic agent; thus, a decrease in estrogen sensitivity (ERα content) in the deep stroma is consistent with the possible beneficial effects of melatonin in the uterine preparation for pregnancy, as observed for the PR receptor (Vázquez et al, 2013).…”

supporting

confidence: 69%

“…The reducing effect of melatonin on E 2 concentration has been reported previously (Noël et al, 1999) and is clearly indicated in the present study (Table 1). Moreover, melatonin decreases E 2 receptor expression in the deep stroma of ewes where the E 2 receptor complex acts as a luteolytic agent (Vázquez et al, 2013), and E 2 concentration has been correlated with the mean response of PGF 2α to oxytocin via the estrogenic stimulation of uterine oxytocin receptors (Beard and Lamming, 1994).…”

Section: Cidr and Cidr Preceded With Melatoninmentioning

confidence: 99%

“…The action of estrogens and P 4 in the uterus is mediated through interactions with their intracellular receptors (estrogen receptor, ER; progesterone receptor, PR; Clark et al, 1992). Melatonin implantation resulted in an increment of the expression of PR in the deep glandular epithelium and a decrease of ER in the deep stroma of ewes (Vázquez et al, 2013). Melatonin increases the sensitivity to P 4 because this hormone enhances the differentiation of the epithelia and, thereby, the secretory function of the endometrium (Cunha et al, 2004).…”

mentioning

confidence: 99%

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Manipulation of reproductive seasonality using melatonin implantation in Anglo-Nubian does treated with controlled internal drug release and equine chorionic gonadotropin during the nonbreeding season

El-Mokadem

El-Din

Ramadan

et al. 2017

Journal of Dairy Science

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The objective of this study was to compare the efficiency of hormonal treatments on ovarian activity and reproductive performance in anestrous Anglo-Nubian does during the nonbreeding season (February to May). A total of 48 multiparous does were divided into 2 groups (24 lactating does and 24 dry does). In each group, animals were allocated randomly into 2 equal subgroups (12 does each). In the first subgroup, does received a single 18-mg melatonin implant for 42 d followed by a controlled internal drug release (CIDR) device for 19 d in conjunction with 500 IU of equine chorionic gonadotropin (eCG) i.m. on the day of CIDR device removal. The second subgroup received CIDR combined with eCG in parallel with the first subgroup. Melatonin implantation induced a luteotrophic effect, expressed as an increasing number of corpora lutea, increased serum progesterone concentration, and reduced estradiol concentration. Regardless of treatment, dry does showed greater value of progesterone concentration. With the advancement of day of treatment, number of total follicles, small follicles, and medium follicles tended to increase to the greatest values at the day of CIDR device insertion. Furthermore, at day of mating, the numbers of large follicles reached the greatest value, which was associated with the lowest value of the number of corpora lutea. At day of mating, serum progesterone concentration achieved the lowest value, which increased until d 56 of pregnancy. The estradiol:progesterone ratio showed the opposite trend. The detrimental effect of reproductive seasonality, expressed as cessation of estrus behavior and fertile mating during the nonbreeding season, was successfully alleviated by the CIDR-eCG protocol. Furthermore, melatonin implantation in conjunction with the CIDR-eCG protocol enhanced conception rate and fecundity at d 28 of pregnancy and prolificacy at d 56 of pregnancy compared with does that were not implanted. Interestingly, does that failed to conceive did not come to heat again. In conclusion, the beneficial effect of melatonin implantation in conjunction with the CIDR-eCG protocol on the luteotrophic effect was reflected in the increasing number of corpora lutea, increasing progesterone concentration, and decreasing estradiol concentration. Furthermore, conception rate, prolificacy, and fecundity were improved compared with does that were not implanted during the nonbreeding season.

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supporting

confidence: 69%

Section: Cidr and Cidr Preceded With Melatoninmentioning

confidence: 99%

mentioning

confidence: 99%

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Manipulation of reproductive seasonality using melatonin implantation in Anglo-Nubian does treated with controlled internal drug release and equine chorionic gonadotropin during the nonbreeding season

El-Mokadem

El-Din

Ramadan

et al. 2017

Journal of Dairy Science

View full text Add to dashboard Cite

show abstract

“…The reducing effect of melatonin on estradiol concentration has also been reported in sheep [38]. Moreover, melatonin decreases the estradiol receptor expression in deep endometrial stroma of ewes, where E2-estradiol receptor complex acts as a luteolytic agent [48]. In ewes, estradiol concentration has also been correlated with the mean response of prostaglandins to oxytocin, via the estrogenic stimulation of uterine oxytocin receptors [49].…”

Section: The Effect Of Exogenous Melatonin On Hormonal Levels and Blomentioning

confidence: 80%

Role of Melatonin in Reproductive Seasonality in Buffaloes

Ramadan¹

2017

Theriogenology

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Buffaloes are characterized by seasonal reproductive activity. Anestrus buffalo heifers and lactating buffaloes were used to study the effect of melatonin treatment on the resumption of ovarian activity during out-of-breeding season. Buffaloes of treated group were injected or implanted with melatonin (18 mg melatonin/50 kg body weight). Using CIDR-eCG protocol preceded with melatonin successfully achieved estrus behavior and induced conception rate during out-of-breeding season. Furthermore, the reproductive performance of buffaloes during out-of-breeding season was clearly improved by melatonin implantation in conjunction with CIDR-eCG protocol due to the luteotrophic effect of melatonin expressed as increasing diameter of CL (corpus luteum) and progesterone concentration. This improvement resulted in greater values of conception rate, in melatonin implanted compared to not implanted buffaloes. Melatonin implantation in anestrus buffalo heifers increased the diameter of largest follicles and melatonin concentration but progesterone and luteinizing hormone (LH) concentrations were decreased. In addition, melatonin implantation in anestrus lactating buffaloes increased the SOD (superoxide dismutase) enzyme activity. Sustained release of exogenous melatonin significantly protects against oxidative stress while increasing beneficial total antioxidant capacity (TAC) concentration in summer-stressed anestrus buffaloes. Melatonin implantation in conjunction with CIDR-eCG protocol successfully improved some blood metabolites, in anestrus buffalo heifers during out-of-breeding season under tropical conditions.

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“…Even more, upregulates SOD and BCL2 and downregulates CAS3 and p53. [111] Ovine Animal Subcutaneous implant of 18 mg Increases viability and pregnancy rate of undernourished ewes [112] Preprints ( …”

Section: Melatoninmentioning

confidence: 99%

Melatonin Scavenger Properties against Oxidative and Nitrosative Stress: Impact on <em>In Vitro</em> Embryo Production in Mammals

Loren¹,

Sánchez²,

Arias³

et al. 2017

Preprint

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Oxidative and nitrosative stress are a common problem when manipulating gametes in vitro. In vitro development in mammalian embryos is highly affected by culture conditions, especially by reactive oxygen species (ROS) and reactive nitrogen species (RNS), because its absence or over production causes embryo arrest and changes in gene expression. Melatonin in gamete co-incubation during IVF has deleterious or positive effects depending on the concentration used in culture medium, demonstrating the delicate balance that must exist between antioxidant and pro-oxidant activity. Further research is needed to better understand the possible impact of melatonin on the different IVP steps in domestic animals, especially in seasonal breeds where this neuro-hormone system highly regulates its reproduction physiology.

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Effect of exogenous melatonin on embryo viability and uterine environment in undernourished ewes

Cited by 13 publications

References 49 publications

Manipulation of reproductive seasonality using melatonin implantation in Anglo-Nubian does treated with controlled internal drug release and equine chorionic gonadotropin during the nonbreeding season

Manipulation of reproductive seasonality using melatonin implantation in Anglo-Nubian does treated with controlled internal drug release and equine chorionic gonadotropin during the nonbreeding season

Role of Melatonin in Reproductive Seasonality in Buffaloes

Melatonin Scavenger Properties against Oxidative and Nitrosative Stress: Impact on <em>In Vitro</em> Embryo Production in Mammals

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