Effect of exercise training on clot strength in patients with peripheral artery disease and intermittent claudication: An ancillary study

Mauer, Karin; Exaire, J. Emilio; Stoner, Julie A.; Saucedo, Jorge; Montgomery, Polly S.; Gardner, Andrew W.

doi:10.1177/2050312115575938

Cited by 5 publications

(4 citation statements)

References 30 publications

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“…LY30 is a measure of thrombolysis within 30 minutes of thrombosis and is used to evaluate fibrinolytic activity. Decreased LY30 indicates decreased fibrinolytic activity and increased clot stability, which may lead to a greater tendency for the blood to form a persistent thrombus (49). Any factor that affects blood circulation in the uterus may increase the risk of pregnancy loss since adequate blood supply is required for embryo implantation and early development (50).…”

Section: Discussionmentioning

confidence: 99%

A new prognostic model for recurrent pregnancy loss: assessment of thyroid and thromboelastograph parameters

Mu,

Huo,

Wang

et al. 2024

Front. Endocrinol.

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ObjectiveThis study aimed to identify predictors associated with thyroid function and thromboelastograph (TEG) examination parameters and establish a nomogram for predicting the risk of subsequent pregnancy loss in recurrent pregnancy loss (RPL).MethodsIn this retrospective study, we analyzed the medical records of 575 RPL patients treated at Lanzhou University Second Hospital, China, between September 2020 and December 2022, as a training cohort. We also included 272 RPL patients from Ruian People’s Hospital between January 2020 and July 2022 as external validation cohort. Predictors included pre-pregnancy thyroid function and TEG examination parameters. The study outcome was pregnancy loss before 24 weeks of gestation. Variable selection was performed using least absolute shrinkage and selection operator regression and stepwise regression analyses, and the prediction model was developed using multivariable logistic regression. The study evaluated the model’s performance using the area under the curve (AUC), calibration curve, and decision curve analysis. Additionally, dynamic and static nomograms were constructed to provide a visual representation of the models.ResultsThe predictors used to develop the model were body mass index, previous pregnancy losses, triiodothyronine, free thyroxine, thyroid stimulating hormone, lysis at 30 minutes, and estimated percent lysis which were determined by the multivariable logistic regression with the minimum Akaike information criterion of 605.1. The model demonstrated good discrimination with an AUC of 0.767 (95%CI 0.725-0.808), and the Hosmer-Lemeshow test indicated good fitness of the predicting variables with a P value of 0.491. Identically, external validation confirmed that the model exhibited good performance with an AUC of 0.738. Moreover, the clinical decision curve showed a positive net benefit in the prediction model. Meanwhile, the web version we created was easy to use. The risk stratification indicated that high-risk patients with a risk score >147.9 had a higher chance of pregnancy loss (OR=6.05, 95%CI 4.09-8.97).ConclusionsThis nomogram well-predicted the risk of future pregnancy loss in RPL and can be used by clinicians to identify high-risk patients and provide a reference for pregnancy management of RPL.

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Section: Discussionmentioning

confidence: 99%

A new prognostic model for recurrent pregnancy loss: assessment of thyroid and thromboelastograph parameters

Mu,

Huo,

Wang

et al. 2024

Front. Endocrinol.

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“…Despite these post-exertion changes in fibrinolysis, exercise does not impact clot strength and clot formation time in claudicants. 28 As mentioned above, the small number of studies, the small number of subjects within studies, and the different modalities and regime of exercise present some of the limitations of this review. It is rather impossible to categorize the mentioned studies into groups with same exercise regimes and reach safe conclusions on how exercise of given intensity and type affects fibrinolysis and coagulation.…”

Section: Discussionmentioning

confidence: 96%

“…Despite these post-exertion changes in fibrinolysis, exercise does not impact clot strength and clot formation time in claudicants. 28…”

Section: Discussionmentioning

confidence: 99%

The effect of exercise on coagulation and fibrinolysis factors in patients with peripheral arterial disease

Patelis

Karaolanis

Kouvelos

et al. 2016

Exp Biol Med (Maywood)

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Peripheral arterial disease is a widely prevalent atherosclerotic occlusive disorder. Symptoms commence with exercise-induced pain in the lower extremities, known as claudication. Despite the fact that exercise has been shown to improve fibrinolytic profile some patients, the effect of exercise on coagulation and fibrinolysis cascades in claudicants has not been comprehensively defined. Literature search in English language yielded 13 studies of exercise on claudicants, including 420 patients. Claudicants tend to have a higher coagulation activity at rest compared to healthy individuals, a trend that persists even after exercise. Post-exercise coagulation activity of claudicants is increased when compared to their respective baseline levels, but it is so in a non-consistent manner. From the available data, it has been suggested that claudicants have a functional and effective fibrinolytic mechanism in place, operating continuously at a relatively higher activity level compared to healthy individuals. Fibrinolysis seems to be activated by exercise; a positive outcome with a prolonged effect as shown by a few of the studies. A final conclusion whether coagulation or fibrinolysis activity is affected mostly by exercise type and intensity in claudicants could not be answered. All conclusions regarding the effect of exercise on the coagulation and fibrinolysis mechanisms should be taken under cautious consideration, due to the limited number of studies, the small number of patients and the different exercise strategies employed in each study. Further randomized studies with similar exercise protocols could provide safer conclusions in the future.

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“…Mauer et al showed that 12-week walking exercise program improves ambulatory function without influencing clot formation in patients with klaudicoperipheral peripheral vascular disease. 29 Re-ambulation period after prolonged immobilization may also be a risk for thrombotic events. 30 Obesity is associated with an increase in thromboembolic events.…”

Section: Discussionmentioning

confidence: 99%

Effect of Home-Based Aerobic Exercise Program on Bleeding Profile and Inflammation in Patients with Behçet's Disease

Koca¹,

Seyithanoğlu²,

Nazik³

et al. 2020

J PMR Sci

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ABS TRACT Objective: Sedentary lifestyle is a major risk factor for cardiovascular disease (CVS) and thrombotic complications. The effect of different types of exercise on platelet function has been the subject of a limited number of studies. Behçet's disease is a multisystemic disease characterized by recurrent oral and genital aphthous lesions and uveitis with unknown etiology. There is an unknown cause of the disease and hyperactivation of the procoagulant cascade and associated mortality due to arterial and venous thrombosis. Here, the effect of aerobic exercise on the bleeding profile and acute phase reactants in Behçet's patients was analyzed experimentally. Material and Methods: Twenty-four (n=24) patients with Behcet's disease were included in the study. Age, height, weight, sex, smoking, known systemic disease (such as diabetes, hypertension, thyroid) and vascular claudication were investigated. Those who didn't complete the protocole (n=5) were excluded from the study. Before and after moderate intensity aerobic exercise program (4 weeks, 3 times a week, 45 minutes per day) sedimentation (ESR), C-reactive protein (CRP), bleeding profile including prothrombin time (PT), prothrombin time percentage (PT%), activated prothrombin time (aPTT), platelet, collagen epinephrine, collagen adenosine diphosphate (ADP) and international normalized ratio (INR) were recorded. Results: Nineteen patients with Behçet's disease were enrolled. The mean age was 37.8±9.8 years. The mean body mass index (BMI) was 28.6±5.5 kg/m 2. Vascular claudication was present in 9 patients (47.4%), smoking in 1 patient (5.3%), and hypertension (10.5%) in 2 patients. While ESR (p=0.028) and collagen ADP (p=0.02) decreased after exercise; platelet count (p=0.005), aPTT (p=0.08), PT (p=0.022) and PT% (p=0.014) were increased. Conclusion: Increase in the duration of aggregation and decrease in inflammation after the exercise program supports that thrombosis can be prevented by exercise. We conclude that short term home-based aerobic exercise program has positive effect on homeostasis in patients with Behçet's disease.

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Effect of exercise training on clot strength in patients with peripheral artery disease and intermittent claudication: An ancillary study

Cited by 5 publications

References 30 publications

A new prognostic model for recurrent pregnancy loss: assessment of thyroid and thromboelastograph parameters

A new prognostic model for recurrent pregnancy loss: assessment of thyroid and thromboelastograph parameters

The effect of exercise on coagulation and fibrinolysis factors in patients with peripheral arterial disease

Effect of Home-Based Aerobic Exercise Program on Bleeding Profile and Inflammation in Patients with Behçet's Disease

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