The effect of exercise on coagulation and fibrinolysis factors in patients with peripheral arterial disease

Patelis, Nikolaos; Karaolanis, Georgios; Kouvelos, George; Hart, Collin; Metheiken, Sean

doi:10.1177/1535370216660215

Cited by 9 publications

(9 citation statements)

References 36 publications

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“…Yes (Womack et al, 2003) Uncertain (Patelis et al, 2016) Yes (Comerota et al, 1997) No Effect (Arora et al, 2005) (Ahlbom et al, 2016) 36% compared to standing, <2 METS (Fares et al, 2016) N/A 12-15% in both supine and seated posture. No change at end of JD.…”

Section: Biochemical Effectmentioning

confidence: 99%

The Endothelium as a Therapeutic Target in Diabetes: A Narrative Review and Perspective

et al. 2021

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Diabetes has reached worldwide epidemic proportions, and threatens to be a significant economic burden to both patients and healthcare systems, and an important driver of cardiovascular mortality and morbidity. Improvement in lifestyle interventions (which includes increase in physical activity via exercise) can reduce diabetes and cardiovascular disease mortality and morbidity. Encouraging a population to increase physical activity and exercise is not a simple feat particularly in individuals with co-morbidities (obesity, heart disease, stroke, peripheral vascular disease, and those with cognitive and physical limitations). Translation of the physiological benefits of exercise within that vulnerable population would be an important step for improving physical activity goals and a stopgap measure to exercise. In large part many of the beneficial effects of exercise are due to the introduction of pulsatile shear stress (PSS) to the vascular endothelium. PSS is a well-known stimulus for endothelial homeostasis, and induction of a myriad of pathways which include vasoreactivity, paracrine/endocrine function, fibrinolysis, inflammation, barrier function, and vessel growth and formation. The endothelial cell mediates the balance between vasoconstriction and relaxation via the major vasodilator endothelial derived nitric oxide (eNO). eNO is critical for vasorelaxation, increasing blood flow, and an important signaling molecule that downregulates the inflammatory cascade. A salient feature of diabetes, is endothelial dysfunction which is characterized by a reduction of the bioavailability of vasodilators, particularly nitric oxide (NO). Cellular derangements in diabetes are also related to dysregulation in Ca2+ handling with increased intracellular Ca2+overload, and oxidative stress. PSS increases eNO bioavailability, reduces inflammatory phenotype, decreases intracellular Ca2+ overload, and increases antioxidant capacity. This narrative review and perspective will outline four methods to non-invasively increase PSS; Exercise (the prototype for increasing PSS), Enhanced External Counterpulsation (EECP), Whole Body Vibration (WBV), Passive Simulated Jogging and its predicate device Whole Body Periodic Acceleration, and will discuss current knowledge on their use in diabetes.

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Section: Biochemical Effectmentioning

confidence: 99%

The Endothelium as a Therapeutic Target in Diabetes: A Narrative Review and Perspective

et al. 2021

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“…The decreased levels of TXB2 might also reflect a lower synthesis of its precursor, thromboxane A2, which is involved in platelet activation and aggregation [ 31 ]. Accordingly, this could reflect the improved fibrinolytic profile induced by regular training [ 32 ]. We further demonstrated that 18-HEPE was found at higher concentrations in the plasma of athletes.…”

Section: Discussionmentioning

confidence: 99%

Sustained Endurance Training Leads to Metabolomic Adaptation

et al. 2022

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Endurance training induces several adaptations in substrate metabolism, especially in relation to glycogen conservation. The study aimed to investigate differences in the metabolism of lipids, lipid-like substances, and amino acids between highly trained and untrained subjects using targeted metabolomics. Depending on their maximum relative oxygen uptake (VO2max), subjects were categorized as either endurance-trained (ET) or untrained (UT). Resting blood was taken and plasma isolated. It was screened for changes of 345 metabolites, including amino acids and biogenic amines, acylcarnitines, glycerophosphocholines (GPCs), sphingolipids, hexoses, bile acids, and polyunsaturated fatty acids (PUFAs) by using liquid chromatography coupled to tandem mass spectrometry. Acylcarnitine (C14:1, down in ET) and five GPCs (lysoPC a C18:2, up in ET; PC aa C42:0, up in ET; PC ae C38:2, up in ET; PC aa C38:5, down in ET; lysoPC a C26:0, down in ET) were differently regulated in ET compared to UT. TCDCA was down-regulated in athletes, while for three ratios of bile acids CA/CDCA, CA/(GCA+TCA), and DCA/(GDCA+TDCA) an up-regulation was found. TXB2 and 5,6-EET were down-regulated in the ET group and 18S-HEPE, a PUFA, showed higher levels in 18S-HEPE in endurance-trained subjects. For PC ae C38:2, TCDCA, and the ratio of cholic acid to chenodeoxycholic acid, an association with VO2max was found. Numerous phospholipids, acylcarnitines, glycerophosphocholines, bile acids, and PUFAs are present in varying concentrations at rest in ET. These results might represent an adaptation of lipid metabolism and account for the lowered cardiovascular risk profile of endurance athletes.

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“…Beberapa kejadian kematian saat melakukan olahraga sering terjadi pada pagi hari yaitu sekitar pukul 09.00 -10.00 (Szymanski & Pate, 1994). Selain menurunkan risiko serangan jantung, olahraga sore dapat meningkatkan aktivitas fibrinolisis sehingga menurunkan viskositas darah (Szymanski & Pate, 1994;Patelis, Karaolanis, Kouvelos, Hart, Metheiken, 2016 (de Oliveira & Burini, 2011;Moses, 1990).…”

Section: Waktu Latihan Atau Berolahraga Terbaikunclassified

Penyuluhan Teknik Berjalan Kaki Yang Benar Bagi Kelompok Lanjut Usia Di Gereja Kristen Indonesia Nurdin, Jakarta

Haryono

Prastowo

2020

JBMI

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The prevalence of non-communicable diseases (PTM) is increasing rapidly. PTM prevention can be done by modifying risk factors such as increased physical activity (sports). Aside from prevention, physical activity has a therapeutic effect. However, choosing one type of exercise is apparently not simple. Many factors must be considered including the level of fitness, age, field conditions and others. Another factor to consider is exercise time. For people without the risk of heart attack, physical exercise (sports) can be done at any time. But it needs to be considered if the sport is done outdoors, it should be done at a safe temperature and humidity. For the high risk group for heart attack, the best exercise time is around 15.00 - 16.00 which is the highest fibrinolytic activity and the lowest coagulation activity, while the least good time is around 09.00 - 10.00 ie the highest coagulation activity and activity the lowest fibrinolytic. Among the many types of exercise, walking is one type of physical activity that is easy and inexpensive. Walking has good health benefits for the elderly. However, walking must be done with the right techniques in order to provide the expected benefits and prevent negative effects, which is minimizing the risks when walking. This counseling is done so that the participants can understand the correct and safe walking technique and do the walking according to the correct techniqueABSTRAK:Prevalensi penyakit tidak menular (PTM) meningkat dengan pesat. Pencegahan PTM dapat dilakukan dengan modifikasi faktor risiko antara lain peningkatan aktivitas fisik (olah raga). Disamping sebagai upaya pencegahan, aktivitas fisik memiliki efek terapi. Namun demikian, memilih satu jenis latihan ternyata tidak sederhana. Banyak faktor harus dipertimbangkan antara lain tingkat kebugaran, usia, kondisi lapangan dan lain-lain. Faktor lain yang perlu dipertimbangkan adalah waktu ber olah raga. Bagi orang tanpa risiko serangan jantung, latihan fisik (olahraga) dapat dilakukan kapan saja. Namun perlu dipertimbangkan bila olahraga dilakukan outdoor, sebaiknya dilakukan pada suhu dan kelembaban yang aman. Bagi kelompok risiko tinggi terhadap serangan jantung, waktu latihan yang paling baik adalah sekitar pukul 15.00 – 16.00 yaitu saat aktivitas fibrinolitik paling tinggi dan aktivitas koagulasi paling rendah, sedangkan waktu yang kurang baik adalah sekitar pukul 09.00 – 10.00 yaitu saat aktivitas koagulasi paling tinggi dan aktivitas fibrinolitik paling rendah. Diantara banyak jenis latihan, jalan kaki adalah salah satu jenis aktivitas fisik yang mudah dan murah. Jalan kaki memiliki manfaat kesehatan yang baik bagi lansia. Namun demikian jalan kaki harus dilakukan dengan teknik yang benar agar memberikan manfaat yang diharapkan dan mencegah efek negatif, yaitu meminimalisir risiko saat melakukan jalan kaki. Penyuluhan ini dilakukan agar para peserta dapat memahami teknik jalan kaki yang benar dan aman serta melakukan jalan kaki sesuai teknik yang benar.

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The effect of exercise on coagulation and fibrinolysis factors in patients with peripheral arterial disease

Cited by 9 publications

References 36 publications

The Endothelium as a Therapeutic Target in Diabetes: A Narrative Review and Perspective

The Endothelium as a Therapeutic Target in Diabetes: A Narrative Review and Perspective

Sustained Endurance Training Leads to Metabolomic Adaptation

Penyuluhan Teknik Berjalan Kaki Yang Benar Bagi Kelompok Lanjut Usia Di Gereja Kristen Indonesia Nurdin, Jakarta

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