Effect of exercise training on vascular endothelial function in patients with stable coronary artery disease: a randomized controlled trial

Luk, Ting-Hin; Dai, Yuk-Ling; Siu, Chung‐Wah; Yiu, Kai‐Hang; Chan, H. S.; Lee, Stephen W L; Li, Sheung-Wai; Fong, Bonnie Mei-Wah; Wong, W. L.; Tam, Sidney; Lau, Chu‐Pak; Tse, Hung‐Fat

doi:10.1177/1741826711415679

Cited by 92 publications

(105 citation statements)

References 36 publications

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“…86 In addition, a combination of statin and angiotensin receptor blocker seems to have a synergistic effect to increase the number and function of EPCs in DM. 85,87 Lifestyle modifications, including exercise 88 and weight reduction, 89 have also been shown to increase EPC number and function in patients with cardiovascular disease or DM.…”

Section: Approaches To Improve Epc Function and Survivalmentioning

confidence: 99%

Specific Role of Impaired Glucose Metabolism and Diabetes Mellitus in Endothelial Progenitor Cell Characteristics and Function

Yiu

Tse

2014

ATVB

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Abstract-The disease burden of diabetes mellitus (DM) and its associated cardiovascular complications represent a growing and major global health problem. Recent studies suggest that circulating exogenous endothelial progenitor cells (EPCs) play an important role in endothelial repair and neovascularization at sites of injury or ischemia. 1 This has been attributed to the occurrence of endothelial dysfunction that leads to the initiation and progression of atherosclerotic vascular disease 2 and impaired neovascularization after ischemia induced by hyperglycemia. 3,4 In patients with impaired glucose metabolism and DM, the vascular endothelium is challenged by inflammation, reactive oxygen species, and deletion of endothelial nitric oxide synthase (eNOS) with resultant endothelial dysfunction.2,5-7 The depletion and dysfunction of the circulating endothelial progenitor cells (EPCs) are thought to underlie the endothelial dysfunction in DM. In this review, the possible mechanisms, functional consequences, and the potential therapeutic approach for impaired EPCs in DM are discussed. A systematic literature search for full-text papers in the English language was performed using MEDLINE, Embase, and the Cochrane library through to February 2014. In the search phrases used, the following terms were combined with the phrase AND Diabetes: endothelial progenitor cells, cardiovascular disease, myocardial infarction, and stroke.

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Section: Approaches To Improve Epc Function and Survivalmentioning

confidence: 99%

Specific Role of Impaired Glucose Metabolism and Diabetes Mellitus in Endothelial Progenitor Cell Characteristics and Function

Yiu

Tse

2014

ATVB

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“…There is convincing evidence that END training improves cardiorespiratory fitness Hambrecht et al 2004;Hao et al 2002;Luk et al 2012;Wisloff et al 2007) in patients with CAD. END training in CAD has also been shown to improve coronary artery endothelial-dependent function (Hambrecht et al 2003), brachial artery FMD (Luk et al 2012;Walsh et al 2003), and heart rate recovery Hai et al 2010;Hao et al 2002;Tsai et al 2005;Wu et al 2006).…”

Section: Supporting Evidence For Endmentioning

confidence: 99%

“…END training in CAD has also been shown to improve coronary artery endothelial-dependent function (Hambrecht et al 2003), brachial artery FMD (Luk et al 2012;Walsh et al 2003), and heart rate recovery Hai et al 2010;Hao et al 2002;Tsai et al 2005;Wu et al 2006). The evidence on carotid artery indices is less definitive.…”

Section: Supporting Evidence For Endmentioning

confidence: 99%

Effects of acute and chronic low-volume high-intensity interval exercise on cardiovascular health in patients with coronary artery disease

Currie

2013

Appl. Physiol. Nutr. Metab.

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The merits of low-volume high-intensity interval exercise (HIT) have been established in healthy populations; however, no studies have examined this exercise prescription in patients with coronary artery disease (CAD). The present thesis examined the acute and chronic effects of HIT in patients with CAD. The first study demonstrated transient improvements in brachial artery endothelial-dependent function, which was assessed using flow-mediated dilation (FMD) 60 min following a single bout of either HIT or moderate-intensity endurance exercise (END) in habitually active patients. The second study demonstrated no effects of training status on the acute endothelial responses to exercise; following 12-weeks of either HIT or END training. However, there was a significant reduction in endothelial-independent function immediately postexercise, at both pre- and post-training, which requires further examination. The third study demonstrated comparable increases in fitness and resting FMD following 12-weeks of END and HIT, lending support to the notion that favourable adaptations are obtainable with a smaller volume of exercise. Finally, the fourth study demonstrated no change in heart rate recovery following 12-weeks of END and HIT. However, pre-training heart rate recovery values reported by our sample were in a low risk range, which suggests training induced improvements may only be achievable in populations with attenuated pre-training values. The results of this thesis provide preliminary evidence that supports the use of HIT in patients with CAD. The findings of favourable transient and chronic improvements following HIT are notable, especially given that the HIT protocol involves less time and work than END, which was modelled after the current exercise prescription in cardiac rehabilitation. Further investigations are necessary, including the assessment of additional physiological indices; the feasibility and adherence to HIT; the inclusion of CAD populations with comorbidities, including heart failure and diabetes; as well as other forms of HIT training, including HIT combined with resistance training.

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“…Recentemente, ensaios clínicos randomizados relataram a eficácia de programas de reabilitação cardíaca (PRC) independentemente do formato dos exercícios: aeróbicos, resistidos ou combinados em pacientes com doenças coronarianas 3,4 ; ainda em outros estudos foram investigados os efeitos do PRC sobre a função vascular endotelial em pacientes com doença coronariana estável 5 , doença cardíaca isquêmi-ca 6 , infarto agudo do miocárdio e doença cardíaca crônica 3,7,8 , porém não há estudos que investigaram a função vascular endotelial em pacientes que participaram de PRC após recente CRM.…”

Section: Introductionunclassified

Efeitos Do Treinamento Físico No Endotélio Após Cirurgia De Revascularização

Aikawa

Signori

Hauck

et al. 2015

Rev Bras Med Esporte

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RESUMOIntrodução: A cirurgia de revascularização do miocárdio (CRM) é uma das mais frequentes cirurgias realizadas em todo o mundo, muitos estudos vêm relatando os benefícios do treinamento físico para a melhora da capacidade funcional, porém há poucos estudos sobre os efeitos na função endotelial vascular. Objetivo: Analisar os efeitos do treinamento físico sobre a função endotelial vascular em pacientes submetidos à CRM, isoladamente na fase tardia da reabilitação após seis meses de programa de reabilitação cardíaca (PCR). Mé-todos: Foram incluídos pacientes que haviam sido submetidos à CRM no período máximo de um ano após a cirurgia. O PRC foi empregado durante seis meses consecutivos, com três sessões semanais. Todos os pacientes realizaram exames laboratoriais, teste de força muscular de uma repetição máxima (1-RM) para os membros superiores e inferiores, teste de caminhada de 6 min (TC6M) e avaliação da função endotelial através da técnica de vasodilatação mediada pelo fluxo. Resultados: Onze pacientes iniciaram o PRC, porém nove pacientes o completaram. A média de idade foi de 66 anos (50 a 82 anos) e o sexo masculino foi predominante (55,6%). Houve mudanças significativas nos exames laboratoriais bioquímicos: aumento do colesterol total (Basal: 162 ± 31mg/dL vs. 195 ± 39mg/dL; P=0,012) e diminuição da hemoglobina glicada (Basal: 6,74 ± 1,64% vs. 6,26 ± 1,62%; P=0,028). A força muscular aumentou significativamente nos membros superiores e inferiores (P=0,030 e P=0,038, respectivamente); no TC6M observou-se um aumento significativo de 20% na distância percorrida (P=0,020) após seis meses consecutivos de treinamento e houve uma melhora na vasodilatação mediada pelo fluxo (Basal: 6,35 ± 3,92% vs. 6 meses: 9,90 ± 4,19%; P=0,026). Conclusão: O treinamento combinado realizado em seis meses ajudou a melhorar a função endotelial e a capacidade funcional de pacientes sedentários que foram submetidos à CRM na fase tardia da reabilitação.Palavras-chave: exercício, endotélio vascular, ponte de artéria coronária, revascularização miocárdica. (6.35 ± 3.92% vs. 9.90 ± 4.19%; P=0.026 ABSTRACT Introduction: The coronary artery bypass graft surgery (CABG) is one of the most common surgeries performed worldwide, many studies have reported the benefits of physical training to improve functional capacity, however there are few studies about the effect of this training on vascular endothelial function. Objective: To analyze the effects of physical training on vascular endothelial function in patients who underwent CABG surgery alone in the last phase of rehabilitation after six months of cardiac rehabilitation program (CRP

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Effect of exercise training on vascular endothelial function in patients with stable coronary artery disease: a randomized controlled trial

Cited by 92 publications

References 36 publications

Specific Role of Impaired Glucose Metabolism and Diabetes Mellitus in Endothelial Progenitor Cell Characteristics and Function

Specific Role of Impaired Glucose Metabolism and Diabetes Mellitus in Endothelial Progenitor Cell Characteristics and Function

Effects of acute and chronic low-volume high-intensity interval exercise on cardiovascular health in patients with coronary artery disease

Efeitos Do Treinamento Físico No Endotélio Após Cirurgia De Revascularização

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