Effect of exercise therapy on quality of life of patients with multiple sclerosis in Iran: a systematic review and meta-analysis

Afkar, Abolhassan; Ashouri, Asieh; Rahmani, Marjan; Sigaroudi, Abdolhosein Emami

doi:10.1007/s10072-017-3047-x

Cited by 15 publications

(10 citation statements)

References 40 publications

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“…Elements of fatigue include increased physical discomfort and need for rest, reduced motivation to perform physical tasks, and difficulty in maintaining physical effort (Fisk et al, 1994) which would likely decrease physical activity levels. A 2017 systematic review of 11 clinical trials found an overall benefit of exercise therapy on mental QoL (Afkar et al, 2017).…”

Section: Physical Activity As a Mediator Of Mental Qolmentioning

confidence: 99%

“…Numerous physiological and psychological pathways provide potential mechanisms that may explain this relationship (Gold et al, 2011;Solaro et al, 2018), as discussed later. Physical activity levels provide another potential intermediary between fatigue and QoL, with fatigue likely to reduce the ability and motivation of pwMS to perform physical activity to levels associated with benefits to QoL (Afkar et al, 2017), mental health, and disease progression (Barry et al, 2016;Motl and Pilutti, 2012). Examination of these mediators may provide insight to potential points of intervention, and inform the development of better treatment pathways for improving QoL in pwMS.…”

Section: Introductionmentioning

confidence: 99%

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Depression mediates the relationship between fatigue and mental health-related quality of life in multiple sclerosis

Fidao

Livera

Nag

et al. 2021

Multiple Sclerosis and Related Disorders

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Background: Fatigue is among the most prevalent symptoms for people with multiple sclerosis (pwMS) and is significantly detrimental to mental health-related (mental) quality of life (QoL). We examined the role of depression and physical activity as mediators in the fatigue-QoL relationship in pwMS. Methods: Using baseline cross-sectional data from an international cohort of 2,104 pwMS, characteristics of fatigue and mental QoL, measured by Fatigue Severity Scale and MSQOL-54 respectively, were assessed using linear and log-binomial regression. Structural Equation Models (SEM) were used to explore the mediating roles of depression and physical activity between fatigue and mental QoL. Results: The median mental QoL score was 71.9/100. The mean fatigue score was 41.5/63, with 65.6% participants having clinically significant fatigue. In the SEM evaluating depression as a mediator of the fatigue-QoL relationship, mental QoL was 14.72 points lower (95% CI: -16.43 -13.01, p<0.001) in participants with clinically significant fatigue, of which depression accounted for 53.0% (-7.80, 95% CI: -9.03 -6.57, p<0.001). In the SEM evaluating physical activity as a mediator of the fatigue-QoL relationship, mental QoL was 10.89 points lower (95% CI: -12.47, -9.32, p<0.001) in participants with clinically significant fatigue, of which the indirect effect via physical activity accounted for only 4.4% (-0.48, 95% CI: -0.81, -0.14, p=0.005). Conclusion: Depression accounted for the majority of the fatigue-mental QoL relationship when modelled as a mediator, while physical activity had only a minor role. Our findings may inform the development of treatments for reducing the impacts of fatigue and improving mental QoL in pwMS.

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Section: Physical Activity As a Mediator Of Mental Qolmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Depression mediates the relationship between fatigue and mental health-related quality of life in multiple sclerosis

Fidao

Livera

Nag

et al. 2021

Multiple Sclerosis and Related Disorders

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“…The impact of a few therapies on QoL was investigated to some extent. [37][38][39][40][41][42][43][44][45][46][47] Drawing firm conclusions on the findings of therapeutic approaches is difficult, due to the treatment choices and methods heterogeneity, and insufficient replication studies (see Supplementary Table 1).…”

Section: Literature Search Findingsmentioning

confidence: 99%

Factors affecting MS patients’ health-related quality of life and measurement challenges in Lebanon and the MENA region

Farran¹,

Safieddine²,

Bayram

et al. 2020

Multiple Sclerosis Journal - Experimental, Translational and Cl

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Background In the Middle East and North Africa (MENA) region, few studies explored the quality of life of multiple sclerosis patients and the factors affecting it. Objective The objective of this study was to explore studies on multiple sclerosis quality of life in the MENA area through a comprehensive literature review. To validate the Multiple sclerosis international Quality of Life (MusiQoL) and Modified Fatigue Impact Scale (MFIS) in Arabic, and investigate the impact of sociodemographic and clinical variables of Lebanese multiple sclerosis patients on quality of life. Methods As part of an ongoing observational prospective research study, data from 663 stable multiple sclerosis patients were analysed. Results In Lebanese multiple sclerosis patients, the Arabic MusiQoL and MFIS seem to be accurate and valid tools with high reliability coefficients and confirmatory factor analytic indices. Variables such as age and disease type predicted multiple sclerosis quality of life, yet were significantly affected by psychosocial fatigue. The influence of sociodemographic and clinical variables on quality of life dimensions varied. Being a woman with multiple sclerosis, receiving medications and experiencing physical fatigue worsens the psychological wellbeing quality of life dimension. Conclusion Several sociodemographic and clinical variables predicted the health-related quality of life dimensions of multiple sclerosis patients in MENA. Further in-depth investigation to guide more targeted clinical management is recommended. We encourage using validated multidimensional tools to measure quality of life in MENA such as the Arabic MusiQoL.

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“…From the psychological perspective, sexual dysfunction in women with MS causes negative mood swings, less attractiveness, changes in gender roles and patterns, difficulties in communicating with a partner, feelings of guilt, fear of rejection, or abandonment of sex (38). Therefore, these negative feelings can lead to the avoidance (39) and improved the quality of life of women with MS (40,41). It could also reduce the symptoms of fatigue (42), thus sexual desire increases with mood improvement, improving the quality of sexual life.…”

Section: Discussionmentioning

confidence: 99%

The effectiveness of Pythagorean self-awareness intervention in improving the quality of sexual life of women with multiple sclerosis

Ahani

Chorami

Sharifi

et al. 2022

J Shahrekord Univ Med Sci

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Background and aims: The present study aimed to determine the effectiveness of Pythagorean self-awareness intervention in improving the quality of sexual life of women with multiple sclerosis (MS). Methods: In this quasi-experimental study, among women with MS in Isfahan province who had medical records in Ayatollah Kashani Hospital and Isfahan MS Center, 150 female patients were enrolled by convenience sampling and screened by Sexual Quality of Life-Female (SQOL-F). After screening, 46 patients, whose quality of sexual life score was lower than the mean score of 63, were randomly assigned to experimental and control groups, each comprising 23 patients. The experimental group received the Pythagorean self-awareness intervention, while the control group received no intervention. Both groups were assessed at pre-test, post-test, and two follow-up stages. The data were analyzed by multivariate analysis of covariance (MANCOVA). Results: The results revealed that the quality of sexual life of the experimental group improved after the intervention (P<0.001). Compared to the pre-test, a significant difference was observed in its components, namely, psychosexual feelings, sexual and relationship satisfaction, self-worthlessness, and sexual repression (P<0.001). Conclusion: It seems that Pythagorean self-awareness intervention effectively improves the quality of sexual life of women with MS. In addition to the overall improvement in the quality of sexual life, a significant difference was observed in its components compared to the pre-test after the intervention. Therefore, it is essential to plan psychological interventions to improve these women’s quality of sexual life.

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Effect of exercise therapy on quality of life of patients with multiple sclerosis in Iran: a systematic review and meta-analysis

Cited by 15 publications

References 40 publications

Depression mediates the relationship between fatigue and mental health-related quality of life in multiple sclerosis

Depression mediates the relationship between fatigue and mental health-related quality of life in multiple sclerosis

Factors affecting MS patients’ health-related quality of life and measurement challenges in Lebanon and the MENA region

The effectiveness of Pythagorean self-awareness intervention in improving the quality of sexual life of women with multiple sclerosis

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