Effect of Exercise Therapy on Monocyte and Neutrophil Counts in Overweight Women

Node, Koichi; Michishita, Ryoma; Tsuruta, Toshiyuki; Shono, Naoko; Inoue, Teruo

doi:10.1097/maj.0b013e3181c6a980

Cited by 42 publications

(22 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our study, we observed exercise-induced reductions in waist circumference, but not BMI, were associated with a decrease in lymphocytes, monocytes, and basophils (Table 3). This is in contrast to Michishita et al who demonstrated that percent change in BMI after 6 weeks of aerobic exercise was associated with a reduction in percent monocytes and neutrophils [17]. A recent study by Arsenault et al from DREW data, and results from the secondary analyses in this cohort, showed no change in either TNF-α or IL-6 after 6 months of exercise([30] and Table 4).…”

Section: Discussioncontrasting

confidence: 74%

“…Men with low fitness and high fatness had higher total WBC, neutrophil, lymphocyte, and basophil counts compared to men with high fitness levels. While acute exercise bouts have been implicated in an augmented inflammatory state [16], high levels of physical activity have been linked to reduced systemic inflammation and aerobic exercise training has been shown to decrease WBC counts [17] and associated inflammatory biomarkers (ex. IL-6) [18].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of Different Doses of Aerobic Exercise on Total White Blood Cell (WBC) and WBC Subfraction Number in Postmenopausal Women: Results from DREW

et al. 2012

View full text Add to dashboard Cite

BackgroundElevated total white blood cell (WBC) count is associated with an increased risk of coronary heart disease and death. Aerobic exercise is associated with lower total WBC, neutrophil, and monocyte counts. However, no studies have evaluated the effect of the amount of aerobic exercise (dose) on total WBC and WBC subfraction counts.PurposeTo examine the effects of 3 different doses of aerobic exercise on changes in total WBC and WBC subfraction counts and independent effects of changes in fitness, adiposity, markers of inflammation (IL-6, TNF-α, C-reactive protein), fasting glucose metabolism, and adiponectin.MethodsData from 390 sedentary, overweight/obese postmenopausal women from the DREW study were used in these analyses. Women were randomized to a non-exercise control group or one of 3 exercise groups: energy expenditure of 4, 8, or 12 kcal kg−1⋅week−1 (KKW) for 6 months at an intensity of 50% VO2peak.ResultsA dose-dependent decrease in total WBC counts (trend P = 0.002) was observed with a significant decrease in the 12KKW group (−163.1±140.0 cells/µL; mean±95%CI) compared with the control (138.6±144.7 cells/µL). A similar response was seen in the neutrophil subfraction (trend P = 0.001) with a significant decrease in the 12KKW group (−152.6±115.1 cells/µL) compared with both the control and 4KKW groups (96.4±119.0 and 21.9±95.3 cells/µL, respectively) and in the 8KKW group (−102.4±125.0 cells/µL) compared with the control. When divided into high/low baseline WBC categories (median split), a dose-dependent decrease in both total WBCs (P = 0.003) and neutrophils (P<0.001) was observed in women with high baseline WBC counts. The effects of exercise dose on total WBC and neutrophil counts persisted after accounting for significant independent effects of change in waist circumference and IL-6.ConclusionAerobic exercise training reduces total WBC and neutrophil counts, in a dose-dependent manner, in overweight/obese postmenopausal women and is especially beneficial for those with systemic low grade inflammation.Clinical Trials Identifier: NCT00011193

show abstract

Section: Discussioncontrasting

confidence: 74%

Section: Introductionmentioning

confidence: 99%

Effect of Different Doses of Aerobic Exercise on Total White Blood Cell (WBC) and WBC Subfraction Number in Postmenopausal Women: Results from DREW

et al. 2012

View full text Add to dashboard Cite

show abstract

“…A single session of moderate aerobic exercise can decrease airway inflammation (but not responsiveness) in mice, with a downregulation of inflammatory mediators' genes expression and Th-2 derived cytokines production [15]. Similar findings have also been demonstrated in one study on humans, where a reduction in neutrophils count in patients with chronic inflammatory conditions was observed [34]. Furthermore, a recent systematic review concludes that physical training improves airway inflammation in animal asthma models [35] and another study shows that it does not increase airway inflammation in children [36].…”

Section: Discussionsupporting

confidence: 59%

Exercise Training, Lymphocyte Subsets and Their Cytokines Production: Experience of an Italian Professional Football Team and Their Impact on Allergy

Giacco

Scorcu²,

Argiolas³

et al. 2014

BioMed Research International

View full text Add to dashboard Cite

Background. In recent years, numerous articles have attempted to shed light on our understanding of the pathophysiological mechanisms of exercise-induced immunologic changes and their impact on allergy and asthma. It is known that lymphocyte subclasses, cytokines, and chemokines show modifications after exercise, but outcomes can be affected by the type of exercise as well as by its intensity and duration. Interesting data have been presented in many recent studies on mouse models, but few studies on humans have been performed to check the long-term effects of exercise over a whole championship season. Methods. This study evaluated lymphocyte subsets and their intracellular IL-2, IL-4, TNF-α, and IFN-γ production in professional football (soccer) players, at three stages of the season, to evaluate if alterations occur, particularly in relation to their allergic status. Results and Conclusion. Despite significant mid-season alterations, no significant lymphocyte subclasses count modifications, except for NKs that were significantly higher, were observed at the end. IL-2 and IL-4 producing cells showed a significant decrease (P = 0.018 and P = 0.001, but in a steady fashion for IL-4), confirming the murine data about the potential beneficial effects of aerobic exercise for allergic asthma.

show abstract

“…Therefore, an improvement of immune function should be an additional part of diabetes therapy beside blood glucose management. There is evidence that regular moderate exercise increases immune function and decreases disease susceptibility, e. g. exercise of moderate intensity induces a decrease in the amount of leukocytes, monocytes, and neutrophils [ 43 ] and improves neutrophil function and natural killer cell activity [ 29 ] .…”

mentioning

confidence: 99%

Endurance Exercise Alters Cellular Immune Status and Resistin Concentrations in Men Suffering from Non-insulin-dependent Type 2 Diabetes

Wenning

Kreutz

Schmidt

et al. 2013

Exp Clin Endocrinol Diabetes

View full text Add to dashboard Cite

It has been demonstrated that alterations of adipocytokines can alter immune status in type 2 diabetes. The present study investigated changes of adipocytokine plasma concentrations and cellular immune status in overweight men, suffering from non-insulin dependent type 2 diabetes (n=14, age 61.0±8.7 years, BMI 31.1±3.5 kg/cm2). Subjects underwent a 3 months endurance exercise intervention (twice per week for up to 45 min) cycling at a heart rate corresponding to a 2 mmol/l lactate threshold. Before and after the intervention testing for adipocytokines (leptin, adiponectin, resistin) and cellular immune status (including T memory-cells and regulative T-cells) was performed by RIA and FACS accordingly.The exercise intervention improved anthropometric and metabolic parameters of all subjects. We observed a significant decline for resistin and for the CD19+ B-cells. The CD4+CD25+CD127low Treg-cells decreased, however not statistically significant. All other parameters remained unchanged.In conclusion, even though only training twice a week, the exercise affected parts of the cellular immune system as well as resistin levels in men suffering from non-insulin dependent type 2 diabetes.

show abstract

Effect of Exercise Therapy on Monocyte and Neutrophil Counts in Overweight Women

Cited by 42 publications

References 30 publications

Effect of Different Doses of Aerobic Exercise on Total White Blood Cell (WBC) and WBC Subfraction Number in Postmenopausal Women: Results from DREW

Effect of Different Doses of Aerobic Exercise on Total White Blood Cell (WBC) and WBC Subfraction Number in Postmenopausal Women: Results from DREW

Exercise Training, Lymphocyte Subsets and Their Cytokines Production: Experience of an Italian Professional Football Team and Their Impact on Allergy

Endurance Exercise Alters Cellular Immune Status and Resistin Concentrations in Men Suffering from Non-insulin-dependent Type 2 Diabetes

Contact Info

Product

Resources

About