Effect of Exercise on Coronary Endothelial Function in Patients With Coronary Artery Disease

Hambrecht, Rainer; Wolf, A; Gielen, Stephan; Linke, Axel; Hofer, Jürgen; Erbs, Sandra; Schoene, Nina; Schuler, Gerhard

doi:10.1097/00008483-200005000-00015

Cited by 370 publications

(503 citation statements)

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“…An improvement in conduit and resistance vessel endothelial function following exercise training has been demonstrated in adults with conditions commonly associated with endothelial dysfunction, such as chronic heart failure [7,8], coronary artery disease [21,22], heart transplantation [23], hypertension [10,11], impaired glucose tolerance [13], type 1 diabetes [14] and type 2 diabetes [15]. However, studies that have investigated the effect of exercise training on microvascular function are more limited and the findings unequivocal.…”

Section: Discussionmentioning

confidence: 99%

Six months of aerobic exercise does not improve microvascular function in type 2 diabetes mellitus

et al. 2006

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Aims/hypothesis Adults with type 2 diabetes mellitus have impaired microvascular function. It has been hypothesised that microvascular function may be restored through regular exercise. The aim of this study was to investigate whether 6 months of regular aerobic exercise would improve microvascular function in adults with type 2 diabetes. Materials and methods Fifty-nine patients with type 2 diabetes (32 males, age 62.9±7.6 years, HbA 1c 6.8±0.9%) were randomised to either a 6-month aerobic exercise programme (30 min, three times a week, 70-80% of maximal heart rate) or a 'standard care' control group. Before and after the intervention period, microvascular function was assessed as the maximum skin hyperaemia to local heating and endothelial and non-endothelial responsiveness following the iontophoretic application of acetylcholine and sodium nitroprusside. Maximal oxygen uptake, as an index of aerobic fitness, was assessed using a maximal exercise test.

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Section: Discussionmentioning

confidence: 99%

Six months of aerobic exercise does not improve microvascular function in type 2 diabetes mellitus

et al. 2006

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“…This concept is based on the findings that exercise intervention programs are able to improve endothelial function in patients with coronary artery disease and chronic heart failure (69,70), and that EPCs are thought to participate in the repair of damaged endothelial cell layers (7,71). In a first study our group investigated the impact of a single exercise bout on the mobilization of EPCs from the bone marrow (8).…”

Section: Physical Exercisementioning

confidence: 99%

Endothelial progenitor cells: Implications for cardiovascular disease

et al. 2008

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“…59,62 Furthermore, exercise training has been shown to improve vascular function in patients with heart failure, 64 type 2 diabetes, 65 metabolic syndrome 66 and CHD. 67 In obese children, combined dietary and exercise treatment improves traditional cardiovascular risk factors. LDL cholesterol and triglycerides are decreased, and HDL cholesterol is increased, both systolic and diastolic BP are decreased, and there are also improvements in insulin resistance.…”

Section: Diet and Exercise Treatmentmentioning

confidence: 99%