Effect of Exercise on Cognition, Conditioning, Muscle Endurance, and Balance in Older Adults With Mild Cognitive Impairment: A Randomized Controlled Trial

Langoni, Chandra da Silveira; Resende, Thais de Lima; Barcellos, Andressa Bombardi; Cecchele, Betina; Knob, Mateus Soares; Silva, Tatiane do Nascimento; Rosa, Juliana Nunes da; Diogo, Tamiris de Souza; Filho, Irênio Gomes da Silva; Schwanke, Carla Helena Augustin

doi:10.1519/jpt.0000000000000191

Cited by 53 publications

(64 citation statements)

References 34 publications

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“…A study evaluating thrice weekly aerobic groups over 12 months (n = 120) in Italian elders with MMSE 24+, reported a significant, small effect on the cognitive primary outcome (MMSE) in favour of the intervention (Muscari et al, 2010). In 34 people with MCI, high-intensity aerobic exercise groups, four days a week had a significant, large effect on executive functioning (though not memory) over 6 months (Baker et al, 2010); while in a second study aerobic exercise twice a week was associated with a significant, moderate effect on global cognition over six months in 60 sedentary individuals with MCI (Langoni et al, 2019).…”

Section: Exercise Interventionsmentioning

confidence: 95%

Efficacy of lifestyle and psychosocial interventions in reducing cognitive decline in older people: Systematic review

Whitty¹,

Mansour²,

Aguirre

et al. 2020

Ageing Research Reviews

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It is unclear what non-pharmacological interventions to prevent cognitive decline should comprise. We systematically reviewed lifestyle and psychosocial interventions that aimed to reduce cognitive decline in healthy people aged 50+, and people of any age with Subjective Cognitive Decline or Mild Cognitive Impairment. We narratively synthesised evidence, prioritising results from studies rated as at lower Risk of Bias (ROB) and assigning Centre for Evidence Based Medicine grades. We included 64 papers, describing: psychosocial (n = 12), multi-domain (n = 10), exercise (n = 36), and dietary (n = 6) interventions. We found Grade A evidence that over 4+ months: aerobic exercise twice weekly had a moderate effect on global cognition in people with/ without MCI; and interventions that integrate cognitive and motor challenges (e.g. dance, dumb bell training) had small to moderate effects on memory or global cognition in people with MCI. We found Grade B evidence that 4+ months of creative art or story-telling groups in people with MCI; 6 months of resistance training in people with MCI and a two-year, dietary, exercise, cognitive training and social intervention in people with or without MCI had small, positive effects on global cognition. Effects for some intervention remained up to a year beyond facilitated sessions.

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Section: Exercise Interventionsmentioning

confidence: 95%

Efficacy of lifestyle and psychosocial interventions in reducing cognitive decline in older people: Systematic review

Whitty¹,

Mansour²,

Aguirre

et al. 2020

Ageing Research Reviews

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“…While more than one-third of the interventions were beneficial, 14 out of 26 controls significantly decreased. Descriptions of intervention and control groups included in the review are presented in Table 3 [29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54]. All of the included studies were considered to have had a good methodological quality, scoring between 7 and 9 points according to the PEDro.…”

Section: Description Of Studiesmentioning

confidence: 99%

Effects of physical exercise on cognitively impaired older adults: a meta-analysis of randomized control trials

Sontáková

Bártová

Daďová

et al. 2020

Preprint

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Objectives: The main aim of this meta-analysis was to compare the effects of different physical activities on cognitive functions in older adults divided according to cognitive impairment levels. Methods: We searched Web of Science, Scopus, and PubMed for randomized control trials (RCT). A standardized mean difference (SMD) of the pre-post intervention score of global cognitive function tests were calculated by the random model in the Cochrane meta-analyses for people with cognitive impairment generally and across three levels - mild, mild to moderate, and moderate to severe cognitive impairment separately. Additionally, an unstandardized coefficient beta (B) was calculated in generalized linear models to estimate the effects of exercise, cognitive impairment severity, age, female ratio, length of intervention, and time of exercise a week on the global cognitive function. Results: Data from 26 studies involving 1,137 participants from intervention groups and 1,187 participants from control groups were analyzed. Physical exercise had a positive effect on cognitive functions in people across all levels of cognitive impairments SMD (95 % confidence interval [CI]) = 1.19 (0.77 - 1.62); however, heterogeneity was considerably high I 2 = 95%. Aerobic (B = 8.881) and resistance exercise (B = 4.464) was significantly associated with better results in global cognitive functions when compared to active control. A higher number of female participants cin intervention groups had a statistically significant effect on the global cognitive function (B = 0.229). onclusions: Physical exercise was associated with cognitive function improvement in older people with cognitive impairments. Aerobic exercise was more strongly associated than resistance exercise to combat cognitive decline. Keywords: Physical activity, Dementia, Aging, Meta-analysis, Aerobic exercise, Cognitive function

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“…[31] Neurobehavioral Considerations Over the past two decades, an explosion of empirical evidence has been published linking lifestyle behaviors to brain function [19,[32][33][34][35][36]. Indeed, great strides have been made at multiple levels of inference, including randomized trials of clinical populations, [37][38][39][40][41]. mechanistic studies within preclinical older adults using neuroimaging modalities, [42][43][44] and animal studies linking neurobehavioral changes to alterations in mitochondrial structure, [45][46][47] neurotrophic, [48,49] and metabolic function [50,51] to underlying changes of neuropathological pathways [52][53][54].…”

Section: Behavior and The Brain: Conceptual Framework Linking Lifestmentioning

confidence: 99%

Pathways of Prevention: A Scoping Review of Dietary and Exercise Interventions for Neurocognition

Smith

2019

BPL

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Alzheimer's disease and related dementias (ADRD) represent an increasingly urgent public health concern, with an increasing number of baby boomers now at risk. Due to a lack of efficacious therapies among symptomatic older adults, an increasing emphasis has been placed on preventive measures that can curb or even prevent ADRD development among middle-aged adults. Lifestyle modification using aerobic exercise and dietary modification represents one of the primary treatment modalities used to mitigate ADRD risk, with an increasing number of trials demonstrating that exercise and dietary change, individually and together, improve neurocognitive performance among middle-aged and older adults. Despite several optimistic findings, examination of treatment changes across lifestyle interventions reveals a variable pattern of improvements, with large individual differences across trials. The present review attempts to synthesize available literature linking lifestyle modification to neurocognitive changes, outline putative mechanisms of treatment improvement, and discuss discrepant trial findings. In addition, previous mechanistic assumptions linking lifestyle to neurocognition are discussed, with a focus on potential solutions to improve our understanding of individual neurocognitive differences in response to lifestyle modification. Specific recommendations include integration of contemporary causal inference approaches for analyzing parallel mechanistic pathways and treatment-exposure interactions. Methodological recommendations include trial multiphase optimization strategy (MOST) design approaches that leverage individual differences for improved treatment outcomes.

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Effect of Exercise on Cognition, Conditioning, Muscle Endurance, and Balance in Older Adults With Mild Cognitive Impairment: A Randomized Controlled Trial

Abstract: The training program improved cognitive function, muscle endurance, aerobic conditioning, and balance in older adults with MCI.

Cited by 53 publications

References 34 publications

Efficacy of lifestyle and psychosocial interventions in reducing cognitive decline in older people: Systematic review

Efficacy of lifestyle and psychosocial interventions in reducing cognitive decline in older people: Systematic review

Effects of physical exercise on cognitively impaired older adults: a meta-analysis of randomized control trials

Pathways of Prevention: A Scoping Review of Dietary and Exercise Interventions for Neurocognition

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