Effect of Exercise on Cardiac and Metabolic Outcomes in People Living With HIV

Yahiaoui, Anella; Smith, Barbara A.; Voss, Joachim

doi:10.1891/0739-6686.31.277

Cited by 4 publications

(4 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Nowadays, HIV infection represents living with a chronic disease, which opens space for non-pharmacological interventions like physical exercise 21 . Physical exercise enables to maintain functionality and improves quality of life 22,23 , as our study has demonstrated. Thus, maintenance of physical and functional aptitude has become one of the priority objectives in the treatment of patients living with HIV/AIDS, mainly those with a diagnosis of pronounced loss of muscle mass 24 .…”

Section: Discussionsupporting

confidence: 63%

Resistance training improves quality of life in people with HIV: a randomized clinical trial

Zanetti

Lourenço

Cruz

et al. 2016

Rev Bras Ativ Fís Saúde

View full text Add to dashboard Cite

The study aimed to evaluate the effect of periodized resistance training on the quality of life of people infected with HIV. Thirty HIV-infected people, sedentary and receiving antiretroviral therapy, were randomly divided into two groups. The resistance training group (RT) participated in a 12-week periodized exercise program while the control group (CON) was asked to maintain daily habits. Before and after the twelve weeks, all volunteers answered a quality of life questionnaire (Patient-Reported Outcomes Quality of Life-HIV) in the Portuguese language version, containing eight domains: 1) physical health and symptoms (PHS); 2) body change (BC); 3) social relationships (SR); 4) intimate relationships (IR); 5) stigma (ST); 6) emotional distress (ED); 7) health concerns (HC); and 8) treatment impact (TI). A mixed-design analysis of variance for repeated measures was used to analyze the effects of time, treatment and interaction, having significant value when p <0.05. Interactions were found for the following domains: PHS (p <0.0001), BD (p <0.0001), SR (p <0.0001), IR (p<0.002), ST (p <0.0001), ED (p <0.0001), HC (P <0.0001) and TI (p <0.0001). RT improves quality of life in HIV-infected individuals and points to the need for its implementation in health care services targeted at this population.

show abstract

Section: Discussionsupporting

confidence: 63%

Resistance training improves quality of life in people with HIV: a randomized clinical trial

Zanetti

Lourenço

Cruz

et al. 2016

Rev Bras Ativ Fís Saúde

View full text Add to dashboard Cite

show abstract

“…After excluding studies pre-ART era, performed or published before or in the year 1996 [75], a significant change in the IG’s upper body strength (19.9 kg [95% CI: 12.3–27.5], p < 0.001) and lower body strength (15.1 kg [95% CI: 11.4–18.8], p < 0.001) was found, where the result for IG upper body strength was higher than that of the main meta-analysis.…”

Section: Resultsmentioning

confidence: 99%

Effects of aerobic and resistance exercise alone or combined on strength and hormone outcomes for people living with HIV. A meta-analysis

et al. 2018

View full text Add to dashboard Cite

BackgroundInfection with human immunodeficiency virus (HIV) affects muscle mass, altering independent activities of people living with HIV (PLWH). Resistance training alone (RT) or combined with aerobic exercise (AE) is linked to improved muscle mass and strength maintenance in PLWH. These exercise benefits have been the focus of different meta-analyses, although only a limited number of studies have been identified up to the year 2013/4. An up-to-date systematic review and meta-analysis concerning the effect of RT alone or combined with AE on strength parameters and hormones is of high value, since more and recent studies dealing with these types of exercise in PLWH have been published.MethodsRandomized controlled trials evaluating the effects of RT alone, AE alone or the combination of both (AERT) on PLWH was performed through five web-databases up to December 2017. Risk of bias and study quality was attained using the PEDro scale. Weighted mean difference (WMD) from baseline to post-intervention changes was calculated. The I2 statistics for heterogeneity was calculated.ResultsThirteen studies reported strength outcomes. Eight studies presented a low risk of bias. The overall change in upper body strength was 19.3 Kg (95% CI: 9.8–28.8, p< 0.001) after AERT and 17.5 Kg (95% CI: 16–19.1, p< 0.001) for RT. Lower body change was 29.4 Kg (95% CI: 18.1–40.8, p< 0.001) after RT and 10.2 Kg (95% CI: 6.7–13.8, p< 0.001) for AERT. Changes were higher after controlling for the risk of bias in upper and lower body strength and for supervised exercise in lower body strength. A significant change towards lower levels of IL-6 was found (-2.4 ng/dl (95% CI: -2.6, -2.1, p< 0.001).ConclusionBoth resistance training alone and combined with aerobic exercise showed a positive change when studies with low risk of bias and professional supervision were analyzed, improving upper and, more critically, lower body muscle strength. Also, this study found that exercise had a lowering effect on IL-6 levels in PLWH.

show abstract

“…Muito embora tenha possibilitado a reconstituição do sistema imunológico e o aumento da sobrevida das pessoas vivendo com HIV/AIDS, o uso prolongado da HAART, assim como a infecção pelo vírus HIV, causam alterações negativas e deletérias ao organismo desses sujeitos, tais como: complicações cardiorrespiratórias (diminuição do consumo de oxigênio), musculares (sarcopenia e diminuição da força muscular), psiquiátricas (depressão), alterações no perfi l bioquímico (redução nos níveis de HDL-c e aumentos de LDL-c e glicose), dentre outras. Essas alterações, quando analisadas separadamente, merecem atenção e, quando agrupadas, levam o organismo a desenvolver problemas cardiovasculares graves [5][6][7][8][9] . Dentre as alterações que pioram a qualidade de vida desses pacientes está a toxicidade mitocondrial de diversos tecidos, entre eles o hepático e o muscular, a qual leva à sua disfunção, fato que contribui substancialmente para a ocorrência de hiperlactacidemia de repouso [10][11] .…”

Section: Palavras-chave: Hiv/aids; Cinética De Lactato; Aptidão Físicunclassified

“…Dentre as alterações que pioram a qualidade de vida desses pacientes está a toxicidade mitocondrial de diversos tecidos, entre eles o hepático e o muscular, a qual leva à sua disfunção, fato que contribui substancialmente para a ocorrência de hiperlactacidemia de repouso [10][11] . Intervenções não-medicamentosas vêm sendo aplicadas para evitar/minimizar as consequências negativas advindas da associação entre a infecção do vírus HIV e o uso da HAART; dentre elas está a adesão ao programa de exercícios físicos regulares 2,5,[8][9][10]12 . Diversos estudos são encontrados na literatura mostrando os benefícios advindos do treinamento físico de força e aeróbio, tais como: aumento e manutenção do consumo máximo de oxigênio, adaptações neurais, aumento da massa e força muscular bem como redução do percentual de gordura, melhora nos perfi s lipídico e glicêmico, diminuição do risco coronariano, síntese de novas mitocôndrias e melhor vascularização (angiogênese), além da manutenção da carga viral e o aumento das células TCD4+ 5,9,[13][14] .…”

Section: Palavras-chave: Hiv/aids; Cinética De Lactato; Aptidão Físicunclassified

Parâmetros bioquímicos e cinética de lactato sanguíneo de sujeitos HIV+ submetidos ao treinamento físico combinado

Trombeta

Vieira

Fernandes

et al. 2015

Rev. bras. educ. fís. esporte

View full text Add to dashboard Cite

Resumo O objetivo deste estudo foi verificar a cinética de lactato sanguíneo (CLS) e a sua resposta ao treinamento físico combinado (TFC) bem como avaliar os efeitos sobre os aspectos bioquímicos, imunológicos, cardiorrespiratório e composição corporal de pessoas vivendo com HIV/AIDS. Doze voluntários HIV+ realizaram o TFC, por um período de 16 semanas, e foram submetidos às avaliações nos momentos pré, oito e 16 semanas de TFC. Ao final, houve um aumento das células TCD4+ e manutenção da carga viral, aumento do consumo máximo de oxigênio e da força muscular e, ainda, aumento do HDL-c e diminuição dos triglicerídeos e glicemia de jejum. Ainda, ocorreu aumento da CLS após o período de treinamento. Concluímos que o TFC influenciou positivamente os parâmetros imunológicos, bioquímicos, cardiorrespiratório e muscular, no entanto, a questão relacionada à CLS necessita de estudos futuros para maiores esclarecimentos.

show abstract

Effect of Exercise on Cardiac and Metabolic Outcomes in People Living With HIV

Cited by 4 publications

References 41 publications

Resistance training improves quality of life in people with HIV: a randomized clinical trial

Resistance training improves quality of life in people with HIV: a randomized clinical trial

Effects of aerobic and resistance exercise alone or combined on strength and hormone outcomes for people living with HIV. A meta-analysis

Parâmetros bioquímicos e cinética de lactato sanguíneo de sujeitos HIV+ submetidos ao treinamento físico combinado

Contact Info

Product

Resources

About