Effect of exercise and lactic acid infusion on individual free fatty acids of plasma

Gold, Martin; Miller, Heather G.; Issekutz, B; Spitzer, John J.

doi:10.1152/ajplegacy.1963.205.5.902

Cited by 24 publications

(21 citation statements)

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“…It has been recognized for many years that lactate inhibits lipolysis both in vivo and in vitro [22][23][24][25]. One can speculate that the decrease in GPR81 expression in adipose tissue could reduce the ability of lactate to inhibit lipolysis and thereby facilitate adipose tissue lipolysis.…”

Section: Resultsmentioning

confidence: 99%

Inflammation inhibits GPR81 expression in adipose tissue

et al. 2011

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Section: Resultsmentioning

confidence: 99%

Inflammation inhibits GPR81 expression in adipose tissue

et al. 2011

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“…That lactate inhibits lipolysis was originally reported in 1963 [56]. Lactate infusion in humans attenuated the increase of blood free fatty acids (FFA) and glycerol during exercise [56,57].…”

Section: Lactate Stops Other Metabolic Routesmentioning

confidence: 99%

“…Lactate infusion in humans attenuated the increase of blood free fatty acids (FFA) and glycerol during exercise [56,57]. The mechanism behind this phenomenon was not understood until recently.…”

Section: Lactate Stops Other Metabolic Routesmentioning

confidence: 99%

Lactate as a Signaling Molecule That Regulates Exercise-Induced Adaptations

Nalbandian

Takeda

2016

Biology

127

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Lactate (or its protonated form: lactic acid) has been studied by many exercise scientists. The lactate paradigm has been in constant change since lactate was first discovered in 1780. For many years, it was unfairly seen as primarily responsible for muscular fatigue during exercise and a waste product of glycolysis. The status of lactate has slowly changed to an energy source, and in the last two decades new evidence suggests that lactate may play a much bigger role than was previously believed: many adaptations to exercise may be mediated in some way by lactate. The mechanisms behind these adaptations are yet to be understood. The aim of this review is to present the state of lactate science, focusing on how this molecule may mediate exercise-induced adaptations.

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“…In diesem Zusammenhang sind in vivo.Versuche am ruhenden Hund und am Menschen yon Bedeutung [13,19,24,30], bei denen ein s NFS-Abfall dureh Lactat-Infusionen hervorgerufen warden konnte, wie er initial bei Muskelarbeit gesehen wird COBB and Johnson [11] fiihrten bei physisch trainierten und untrainierten Personen Belastungen durch. Die trainierten reagierten auf die Belastung mit einem geringeren Anstieg des Laetats als die untrainierten.…”

Section: The Influence Of Lactic Acid On Rat Adipose Tissue Lipolysisunclassified

In vitro versuche zur antilipolytischen Wirkung von Milchs�ure

Dieterle

Bottermann

et al. 1969

Diabetologia

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The influence of lactic acid on rat adipose tissue lipolysis was studied in vitro. Good correlation was found between lactic acid concentration in the medium and inhibition of lipolysis. The correlation was equally good between pyruvate production into the medium and/or lactate to pyruvate ratios and inhibition of lipolysis. So far no answer can be given whether the observed inhibition of lipolysis is a direct or indirect (pyruvate) metabolic effect of lactic acid. The possibility of an inhibition of lipolysis mediated by lactic acid during muscular exercise is discussed.Etude de l'aetion antilipolytique de l'acide lactique in vitro l~sumg. L'in~uence de l'acide lactique sur la lipolyse a 6t6 6tudide in vitro sur le tissu adipeux du rat. L'acide lactique inhibe la lipolyse ell proportion de la dose appliqugc. I1 y avait 6galement une bonnc eorrglation entre t'inhibition de la lipolyse et la production de pyruvate duns le milieu et/ou les rapports lactate sur pyruvate. On ne peut distingucr, si l'inhibition de la lipolyse est un effet m6taboIique direct de l'acide lactique ou d6pend de la production de pyruvate. L'inhibition de la lipolyse par l'acide lactique pendant le travail musculaire in vivo est discut6e. Zusammenfassung. Der Einflul] yon 1Viilchs/~ure auf die Lipolyse wird in vitro am isolierten Fettgewebe untersucht. Milchsaure bewirkt eine dosisabh/~ngige tIemmung der Lipolyse. Es kann nicht entschieden werden, ob die Antilipolyse ein direkter Stoffwechseleffekt der Mflchsaure ist oder nut durch diese vermittelt wird. Auffallig ist die zunehmende Itemmung der Lipolyse mit Anstieg des Redox-Potentials. Die M6glichkeit einer laetatbedingten Lipolysehemlnung in vivo w~ihrend muskuli~rer Arbeit wird diskutiert.

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Effect of exercise and lactic acid infusion on individual free fatty acids of plasma

Cited by 24 publications

References 0 publications

Inflammation inhibits GPR81 expression in adipose tissue

Inflammation inhibits GPR81 expression in adipose tissue

Lactate as a Signaling Molecule That Regulates Exercise-Induced Adaptations

In vitro versuche zur antilipolytischen Wirkung von Milchs�ure

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