Effect of Evolvulus alsinoides on lipid metabolism of streptozotocin induced diabetic rats

Gomathi, D.; Ravikumar, Ganesan; Kalaiselvi, M.; Devaki, Kanakasabapathi; Uma, C.

doi:10.1016/s2222-1808(13)60037-7

Cited by 7 publications

(6 citation statements)

References 13 publications

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“…Deficiency of insulin leads to inactivation of lipoprotein lipase which caused the increased mobilization of free fatty acids from peripheral deposits leading to dyslipidemia [30]. In this study, HPE treatment significantly restored (p<0.05) the total cholesterol, triglycerides, and HDL level in diabetic rats as shown in Figure 3a, Figure 3b and Figure 3c.…”

Section: Effect Of Hpe Treatment On Blood Glucose Lipid Profile Andsupporting

confidence: 59%

Hibiscus sabdariffa (ROSELLE) POLYPHENOL-RICH EXTRACT PREVENTS THE AORTIC OXIDATIVE DAMAGE IN TYPE 1 DIABETIC RATS

et al. 2018

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Diabetes mellitus complications mainly occur due to the oxidative stress-related condition. Thus, this study aimed to investigate the protective effect of the polyphenol-rich extract of Hibiscus sabdariffa (roselle) (HPE) on the aorta of streptozotocin-induced diabetic rats. Twenty-four male Sprague-Dawley rats were divided into four groups (n=6/group); non-diabetes control (NDM), diabetes (DM), diabetes treated with HPE (DM+HPE) and metformin (DM+MET). HPE and metformin were given orally at the dose of 100mg/kg and 150mg/kg respectively for eight weeks duration. At the end of the experiment period, blood pressure was measured before the rats were sacrificed. Blood was taken for measurement of plasma glucose and lipid levels whilst aorta was excised for oxidative stress and histological evaluation. Results showed that HPE treatment reduced plasma glucose level, blood pressure and improved dyslipidemia significantly (p<0.05) in DM+HPE group compared to DM group. Malondialdehyde (MDA) and advanced oxidation protein product (AOPP) levels were significantly decreased (p<0.05) while GSH level was significantly increased (p<0.05) in DM+HPE group compared to DM group. No histological changes observed in the aorta of all diabetic groups compared to NDM group. In conclusion, HPE might have a potential in minimizing the risk of vascular damage in diabetic conditions.

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Section: Effect Of Hpe Treatment On Blood Glucose Lipid Profile Andsupporting

confidence: 59%

Hibiscus sabdariffa (ROSELLE) POLYPHENOL-RICH EXTRACT PREVENTS THE AORTIC OXIDATIVE DAMAGE IN TYPE 1 DIABETIC RATS

et al. 2018

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“…On the other hand, an abnormal lipid profile was observed in the diabetic rats when compared to the normal group. This may be because of the imbalance in the various metabolic and regulatory pathways developed that are mainly due to the deficiency of insulin [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

Mechanisms of Antidiabetic Activity of Methanolic Extract of Punica granatum Leaves in Nicotinamide/Streptozotocin-Induced Type 2 Diabetes in Rats

Shinu

Nain

Morsy

et al. 2020

Plants

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The current study aimed to establish the mechanisms of antidiabetic activity of methanolic extract of Punica granatum leaves (MEPGL) in nicotinamide/streptozotocin-induced type 2 diabetes in rats. Phytochemical screening, HPLC analysis, and acute toxicity study of MEPGL were carried out. Various concentrations of MEPGL (100, 200, 400, and 600 mg/kg) were administered orally to diabetic rats for 45 days on a daily basis. The antidiabetic effect of MEPGL was examined by measuring blood glucose, plasma insulin, and glycated hemoglobin (HbA1c) levels, as well as with an oral glucose tolerance test. The antioxidant effect of MEPGL was determined by analyzing hepatic and renal antioxidant markers, namely superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH), and lipid peroxidation. The other biochemical markers alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), urea, and creatinine, as well as total cholesterol, triglycerides, and high-density lipoprotein (HDL) were also studied. Type 2 diabetes significantly altered these parameters, while oral administration of the MEPGL significantly ameliorated them. Moreover, the pancreatic histopathological changes were attenuated with MEPGL treatment. In a nutshell, oral MEPGL administration in diabetic rats showed antidiabetic activity due to its antioxidant activity, most probably due to the gallic acid, ellagic acid, and apigenin found in MEPGL.

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“…Dyslipidaemia is a well-known complication in diabetes [51]. In normal, non-diabetic state, insulin tends to increase receptor-mediated uptake of LDL-cholesterol, hence decreasing activity of insulin but during diabetes, hypercholesterolemia may occur by a way of increased β-oxidation of fatty acids which generate a lot of acetyl-coA and increased cholesterol synthesis [52]. In line with previous studies, uncontrolled diabetes causes increase in total cholesterol, triglycerides and LDL cholesterol associated with decrease in HDL [53][54].…”

Section: Discussionmentioning

confidence: 99%

In vitro Antioxidant, Antihyperglycaemic and Antihyperlipidaemic Activities of Ethanol Extract of Lawsonia inermis Leaves

Ojewunmi

2014

BJPR

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Aim: This present study investigated the free radical scavenging activities, antihperglycaemic and antihyperlipidaemic activities of ethanol extract of Lawsonia inermis leaves. Study Design: Twenty male rats were randomly and evenly distributed into four groups, and were subsequently exposed to the following treatments for twenty-one days: Group I (Control): Normal saline; Group II: Untreated Diabetic control; Group III: Diabetic rats treated with glibenclamide (600mg/Kg. b.wt); Group IV: Diabetic rats treated with ethanol extract of Lawsonia inermis (400mg/Kg b.wt).

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Effect of Evolvulus alsinoides on lipid metabolism of streptozotocin induced diabetic rats

Cited by 7 publications

References 13 publications

Hibiscus sabdariffa (ROSELLE) POLYPHENOL-RICH EXTRACT PREVENTS THE AORTIC OXIDATIVE DAMAGE IN TYPE 1 DIABETIC RATS

Hibiscus sabdariffa (ROSELLE) POLYPHENOL-RICH EXTRACT PREVENTS THE AORTIC OXIDATIVE DAMAGE IN TYPE 1 DIABETIC RATS

Mechanisms of Antidiabetic Activity of Methanolic Extract of Punica granatum Leaves in Nicotinamide/Streptozotocin-Induced Type 2 Diabetes in Rats

In vitro Antioxidant, Antihyperglycaemic and Antihyperlipidaemic Activities of Ethanol Extract of Lawsonia inermis Leaves

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