Effect of Ethyl Acetate Extracts from Peel of Citrus decumana and Citrus aurantifolia on Aspirin Induced Gastric Ulcer in Mice

Egwim, Evans Chidi; Hamzah, Rabiat Unekwu; Adepeju, Aberuagba

doi:10.9734/bjpr/2015/6674

Cited by 3 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…aurantifolia include remedy of stomach illnesses, diarrhea, malaria and urinary tract infection [ 145 ]. Phytochemical constituents of the aqueous extract of C. aurantifolia include; flavonoids, cardiac glycosides, steroids, alkaloids, tannins, saponins and reducing sugars [ 146 , 147 ]. Studies have reported the presence of isolated compounds in C. aurantifolia including: phellopterin; quercetin; 2,4,6-trichloroanisole; β-bisabolene; 6,7- dimethoxycoumarin; 9,10-dimethyl-1,2- benxanthracene; bergamottin; kaempferol; camphene; isopimpinellin; o-cymene; 5-geranoxy-7-methoxy-coumarin; citronellol; rutin; citronellol; 8-geranoxypsoralen; berfapten; terpinolene; monoterpenes; apigenin; b-pinene; sitosterol; furocoumarins; nobiletin; coumarins; terpinolene; lycopene and quercetin [ 148 , 149 , 150 , 151 ].…”

Section: Resultsmentioning

confidence: 99%

“…Hence, the extract has a gastroprotective effect. Thus, the extract has a potential remedy for management of ulcerogenic disorders [ 146 ]. The fruit and essential oil from C. aurantifolia at 250 mg/kg, demonstrated cytoprotection of gastric membrane in the ethanol induced ulcer model in experimental animal [ 147 ].…”

Section: Resultsmentioning

confidence: 99%

“… Lauraceae Leaves and fruits 1A and 4A [ 126 ] 1D and 4B Quercetin and quercetin-3-o-rhamnoside [ 74 , 75 ] Citrus aurantifolia Linn. Rutaceae Leaves 1C [ 146 ], 2A [ 158 ] and 4A [ 147 ] 1D, 2B and 4B Rutin, quercetin, kaempferol, stigmasterol and β sitosterol [ 74 , 75 ] Spondias mombin Linn. Anacardiaceae Leaves and fruits 1A, 2A [ 134 , 135 ] 1B, 4A and 5A [ 143 ] 1D, 2B, 4B and 5B Gallic and ellagic acid [ 134 , 135 ] Bidens pilosa L. Asteraceae Whole plants 1A, 4A [ 179 , 180 ] and 5A [ 179 ] 1D, 4B and 5B 2,4-dihydroychalcone [ 171 ] Dyspepsia FDA Reg.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

A review on anti-peptic ulcer activities of medicinal plants used in the formulation of Enterica, Dyspepsia and NPK 500 capsules

Kumadoh

Archer

Yeboah

et al. 2021

Heliyon

View full text Add to dashboard Cite

Peptic ulcer disease affects many people globally. With the increasing resistance to some orthodox antibiotics such as Clarithromycin and Metronidazole, it is important that new acceptable, safer and effective therapies are developed to manage this disease. Various herbal medicines have been used traditionally for the remedy of peptic ulcer disease (PUD), however scientific information with regards to their anti-peptic ulcer both in-vivo and invitro as well as clinical studies supporting their use is still inadequate. The Centre for Plant Medicine Research, (CPMR) Mampong-Akuapem, Ghana manufactures three herbal Products namely Enterica, Dyspepsia and NPK 500 capsules which are currently used for the remedy of PUD as a triple therapy at its out-patient clinic with promising effects. The aim of this review is to gather information from literature on the anti-ulcer properties, pharmacological, phytochemical constituents and related activities of herbal plants used at the CPMR for formulation of the triple herbal therapy. This review may, provide some scientific bases for the use of Enterica, Dyspepsia and NPK 500 capsules in the management of Peptic ulcer at the CPMR out-patient clinic. Methods: Organization for the review involved the on and/or offline search for information from available literature using electronic data and scientific research information resources such as PubMed, Science Direct and Google scholar. Results: In this review, fifteen ethno-medicinal plants used for the formulation of Enterica, Dyspepsia and NPK capsules have been discussed, presenting the description of the plants, composition and pharmacological activity. Interpretation: Tables with the summary of reviewed medicinal plants with their anti-ulcer models and inference on possible mechanisms of action were drawn up. The mechanism(s) of action of individual plants and products (Enterica, Dyspepsia and NPK 500 capsules) must be further investigated and established experimentally in-vitro in addition to in-vivo pharmacological and clinical activity studies to confirm their use in the remedy of PUD.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

A review on anti-peptic ulcer activities of medicinal plants used in the formulation of Enterica, Dyspepsia and NPK 500 capsules

Kumadoh

Archer

Yeboah

et al. 2021

Heliyon

View full text Add to dashboard Cite

show abstract

Gastroprotective Role of Fruit Extracts in Gastric Damage Induced by Non-Steroidal Anti-Inflammatory Drugs: A Systematic Review

Garrido-Valdes,

Díaz-Velis,

Valdes-Gonzalez

et al. 2023

Journal of Medicinal Food

View full text Add to dashboard Cite

Effects of quinine on gastric ulcer healing in Wistar rats

Adeniyi

Makinde

Friday

et al. 2017

Journal of Complementary and Integrative Medicine

View full text Add to dashboard Cite

Background Quinine (QT) is an important anti-malarial drug; however, there is little information about its effects on the gut. Therefore, this study aimed to investigate the effects of a therapeutic dose of QT on the healing of gastric ulcer in rats. Methods Male Wistar rats weighing 150-200 g were divided into three groups: control rats without ulcer (group 1), ulcerated rats treated with 1 mL/kg (p.o.) normal saline (NS) (group 2), and ulcerated rats treated with 10 mg/kg (p.o.) QT (group 3). Ulcers were induced by serosal application of 80 % acetic acid to the stomach of rats anaesthetized with 50 mg/kg thiopentone sodium and treatment was given three times daily. Healing was assessed on days 3, 7 and 10 after ulcer induction by macroscopic measurement of: ulcer area, histology, lipid peroxidation, superoxide dismutase activity and gastric mucus secretion. Results At day 3, there was no significant difference (p>0.05) in ulcer areas between NS- and QT-treated rats. By day 10, however, the percentage area healed in NS treated (59.6±2.35 %) was significantly higher (p<0.05) than in QT rats (49.0±2.20 %) and clearing of inflammatory cells and re-epithelization was greater in NS-treated group. By days 7 and 10, lipid peroxidation was significantly higher in QT animals, when compared with NS-treated rats and controls (p<0.05). Superoxide dismutase activity and mucus secretion were significantly (p<0.05) higher in NS-treated than QT-treated rats. Conclusions QT delayed ulcer healing by prolonging the inflammatory phase of healing, increasing oxidative stress, reducing antioxidant activity and gastric mucus secretion.

show abstract

Effect of Ethyl Acetate Extracts from Peel of Citrus decumana and Citrus aurantifolia on Aspirin Induced Gastric Ulcer in Mice

Cited by 3 publications

References 0 publications

A review on anti-peptic ulcer activities of medicinal plants used in the formulation of Enterica, Dyspepsia and NPK 500 capsules

A review on anti-peptic ulcer activities of medicinal plants used in the formulation of Enterica, Dyspepsia and NPK 500 capsules

Gastroprotective Role of Fruit Extracts in Gastric Damage Induced by Non-Steroidal Anti-Inflammatory Drugs: A Systematic Review

Effects of quinine on gastric ulcer healing in Wistar rats

Contact Info

Product

Resources

About