A review on anti-peptic ulcer activities of medicinal plants used in the formulation of Enterica, Dyspepsia and NPK 500 capsules

Abstract

Peptic ulcer disease affects many people globally. With the increasing resistance to some orthodox antibiotics such as Clarithromycin and Metronidazole, it is important that new acceptable, safer and effective therapies are developed to manage this disease. Various herbal medicines have been used traditionally for the remedy of peptic ulcer disease (PUD), however scientific information with regards to their anti-peptic ulcer both in-vivo and invitro as well as clinical studies supporting their use is still inadequate. The Centre for Plant Medicine Research, (CPMR) Mampong-Akuapem, Ghana manufactures three herbal Products namely Enterica, Dyspepsia and NPK 500 capsules which are currently used for the remedy of PUD as a triple therapy at its out-patient clinic with promising effects. The aim of this review is to gather information from literature on the anti-ulcer properties, pharmacological, phytochemical constituents and related activities of herbal plants used at the CPMR for formulation of the triple herbal therapy. This review may, provide some scientific bases for the use of Enterica, Dyspepsia and NPK 500 capsules in the management of Peptic ulcer at the CPMR out-patient clinic. Methods: Organization for the review involved the on and/or offline search for information from available literature using electronic data and scientific research information resources such as PubMed, Science Direct and Google scholar. Results: In this review, fifteen ethno-medicinal plants used for the formulation of Enterica, Dyspepsia and NPK capsules have been discussed, presenting the description of the plants, composition and pharmacological activity. Interpretation: Tables with the summary of reviewed medicinal plants with their anti-ulcer models and inference on possible mechanisms of action were drawn up. The mechanism(s) of action of individual plants and products (Enterica, Dyspepsia and NPK 500 capsules) must be further investigated and established experimentally in-vitro in addition to in-vivo pharmacological and clinical activity studies to confirm their use in the remedy of PUD.

Antioxidant and Gastroprotective Activity of Suaeda fruticosa Forssk. Ex J.F.Gmel

“…Similarly, another research group performed LC-MS analysis of a 70% aqueous-ethanolic extract of S. vermiculata and found nine different compounds, including flavonoids and one fatty acid—hexadecanoic acid—which we also observed in our GC-MS analysis [ 32 ]. These branched chain fatty acids have also been identified in other plants exhibiting gastroprotective activity [ 33 ], and they are also described for their anti-inflammatory activity [ 34 ].…”

“…Several drugs offer gastroprotection by stimulating mucus secretion, including sucralfate [ 40 ], carbenoxolone [ 41 ], misoprostol [ 42 ], and bismuth compounds [ 43 ]. Several plants have also been reported to display gastroprotection by increasing mucus contents, thus indicating that the antiulcerogenic activity of the plants is linked to the strengthening of the mucosal barrier [ 33 ]. Damage to the gastric tissue is accompanied by a decrease in adherent mucus contents.…”

A study of the therapeutic mechanism of Jakyakgamcho-Tang about functional dyspepsia through network pharmacology research

“…quercetin promotes protein absorption through the internalization of digested oligopeptides in the intestinal epithelium Rather than increasing intracellular permeability [118]. Kaempferol has been studied to have a positive effect on anti-peptic ulcer activity [119] Medicarpin act on DRD1 receptor. DRD1 is a kind of dopamine receptor and is widely distributed in the enteric nervous system such as colon, gastroesophageal junction, pylorus, small intestine and stomach [120].…”

Evaluation of the protective effect of agar-hp hard capsule for peptic ulcer in experimental animals

“…Many herbs and plant materials are found to play important roles in protecting against or serving to heal abdomen ulcers. 2 It has often been used in many Asian traditional medicine systems to treat various illnesses, including ulcers. 3 Also, natural compounds from a plant usually have fewer adverse effects compared with synthetic medications.…”