Effect of ether- and water-soluble fractions of<i>Carica papaya</i>ethanol extract in experimentally induced hyperlipidemia in rats

Iyer, Deepa; Sharma, Brajesh Kumar; Patil, U. K.

doi:10.3109/13880209.2011.596210

Cited by 11 publications

(7 citation statements)

References 9 publications

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“…Traditionally, different parts of the papaya plant are used in the treatment of various ailments such as asthma, ulcers, eczema, diabetes, helminth infections and fever (Nguyen et al 2013). Research also demonstrated its beneficial traditional role in wound healing, and in the treatment of cardiovascular diseases, dengue fever, cancer, malaria, hypoglycemia, hyperlipidemia, fungal diseases and as a male contraceptive (Gupta et al 1990;Nayak et al 2007;Goyal et al 2010;Otsuki et al 2010;Iyer et al 2011;Pedro et al 2011;Kovendan et al 2012;Yasmeen & Prabhu 2012;Nunes et al 2013). Papaya extracts have also been reported to have significant anti-inflammatory activity (Owoyele et al 2008;Lee et al 2011).…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory and immunomodulatory properties of Carica papaya

Pandey

Cabot

Shaw

et al. 2016

Journal of Immunotoxicology

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Chronic inflammation is linked with the generation and progression of various diseases such as cancer, diabetes and atherosclerosis, and anti-inflammatory drugs therefore have the potential to assist in the treatment of these conditions. Carica papaya is a tropical plant that is traditionally used in the treatment of various ailments including inflammatory conditions. A literature search was conducted by using the keywords ''papaya'', ''anti-inflammatory and inflammation'' and ''immunomodulation and immune'' along with cross-referencing. Both in vitro and in vivo investigation studies were included. This is a review of all studies published since 2000 on the antiinflammatory activity of papaya extracts and their effects on various immune-inflammatory mediators. Studies on the anti-inflammatory activities of recognized phytochemicals present in papaya are also included. Although in vitro and in vivo studies have shown that papaya extracts and papaya-associated phytochemicals possess anti-inflammatory and immunomodulatory properties, clinical studies are lacking. ARTICLE HISTORY

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Section: Introductionmentioning

confidence: 99%

Anti-inflammatory and immunomodulatory properties of Carica papaya

Pandey

Cabot

Shaw

et al. 2016

Journal of Immunotoxicology

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“…In this concern, previous studies revealed that water extract of papaya fruits contains significant amounts of α-tocopherol (Ching and Mohamed, 2001), benzylisothiocyanate (Basu and Haldar, 2008), alkaloids such as carpasemine and carpain (Iyer et al, 2011), lycopene (van A photo micrograph in kidney tissue of (A) control rat showing the normal density of total protein in renal tubular epithelial cells manifested by the blue color reaction, (B) rats treated with WE showing the normal distribution of bromophenol blue reaction, (C) rats treated with EE showing normal distribution of bromophenol blue reaction in different renal tissues, (D) rats fed OTA-contaminated diet showing the distribution of protein reaction in renal tubules, renal corpuscles and the hyaline casts revealed weak reaction in some tubules (arrow) and mild reaction in the glomruler tufts, (E) rats fed OTA-contaminated diet and treated wit WE showing strong reaction in the renal tubules (inset) and a moderate reaction in the glomeruli and (F) rats fed OTA-contaminated diet and treated with EE showing a moderate reaction in the renal tubules have moderate reaction and mild reaction in the glomeruli. Breemen and Pajkovic, 2008), proteolytic enzymes such as chymopapain and papain (Seigler et al, 2002), cystatin, ascorbic acid, cyanogenic glucosides and glucosinolates (Seigler et al, 2002), triterpenes, organic acids (Cowan, 1989;Osuna-Torres et al, 2005), as well as flavonoids (Miean and Mohamed, 2001).…”

Section: Discussionmentioning

confidence: 99%

“…After 30 min at room temperature, the absorbance was measured at 765 nm using V-530 UV/visible spectrophotometer. Estimation of phenolic compounds as catechin equivalents was carried out using standard curve of catechin (Jayaprakasha et al, 2003).…”

Section: Determination Of Total Phenolic Compoundsmentioning

confidence: 99%

Papaya fruits extracts enhance the antioxidant capacity and modulate the genotoxicity and oxidative stress in the kidney of rats fed ochratoxin A-contaminated diet

2017

J App Pharm Sci

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Ochratoxin A (OTA) is a mycotoxin widespread contaminates food and has potent nephrotoxicity. The present study aimed to determine total phenolics and DPPH radical scavenging activity for water and ethanolic extracts (WE and EE) of papaya fruits and evaluation of the protective role of these extracts against OTA-induced oxidative damage and nephrotoxicity in rats. Sixty male Sprague-Dawley rats were divided into six groups and treated for 21 days as follow: the control group, OTA-treated group (3 mg/kg diet), WE or EE extracts treated groups (250 mg/kg b.w) and OTA plus WE or EE-treated groups. Blood and kidney samples were collected for different biochemical, cytogenetical and histological analyses. The results showed that WE and EE contained 408.54 and 296.85 g/kg total phenolic, respectively and DPPH radical scavenging activity was higher in WE than EE. Animals fed OTA-contaminated diet showed signs of toxicity as indicated by the significant decrease in body weight gain and food intake, the disturbances in kidney biochemical indices, increase DNA fragmentation and oxidative stress markers, the decrease in antioxidant enzymes activities and gene expression as well as severe histological and histochemical changes in the kidney tissues. Both extracts succeeded to counteract these alterations and WE was more effective than EE. These results concluded that papaya fruits extracts succeeded to a great extant to counteract the oxidative stress of OTA and to protect the kidney against its toxic effects and may be promising candidate as food supplement for the protection against OTA in high endemic area.

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“…Papaya contains alpha-tocopherol, lycopene, benzylisothiocynate, proteolytic enzymes such a papain and chymopapain [73][74][75][76]. The phytochemical constituent of papaya contains various forms of alkaloids; carpain and carpasemine [77], triterpenes, organic acids [78,79]. Moreover, they also have cystatin, ascorbic acid, cyanogenic glucosides and glucosinolates [80] phenols [38] and flavonoids [80].…”

Section: Alternative and Complimentary Management Of Mycotoxicosis Hementioning

confidence: 99%

Evidence Based Phytopharmacological Potential of Herbal Extracts in Post-Ingestion Management of Mycotoxins in Animal Models

RMJ¹

2015

J Clin Toxicol

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Aflatoxins and ochratoxins are common mycotoxic food poisons and acute doses are responsible for causing liver and kidney damage and hepatocarcinoma. The strategy for managing mycotoxins has mainly been pre-ingestive. However, few solutions have been proposed for post-ingestion management and likewise there is no antidote for managing the condition. Studies have demonstrated that Saccharomyces cerevisiae and herbal extracts have potential of limiting the damage caused by reactive oxygen species and toxic effects associated with mycotoxins. Further evidence also shows that herbal extracts provides protection to a variety of cancer cell lines associated with mycotoxins. This study therefore examines the probable potential and options of using medicinal herbal extracts, on their own or in combinations with Saccharomyces cerevisiae, in the management of mycotoxicosis. A combination of the two has potential to offer a multifunctional approach in the management of post ingested mycotoxins such as aflatoxins and ochratoxins.

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Effect of ether- and water-soluble fractions ofCarica papayaethanol extract in experimentally induced hyperlipidemia in rats

Abstract: The anti-hyperlipidemic effect was evaluated in olive oil-loaded rats. Acute treatment caused stimulatory effect on HDL level and inhibition in TC and TG elevation induced by olive oil. The extract and water fraction showed protective action by increasing the HDL cholesterol level.

Cited by 11 publications

References 9 publications

Anti-inflammatory and immunomodulatory properties of Carica papaya

Anti-inflammatory and immunomodulatory properties of Carica papaya

Papaya fruits extracts enhance the antioxidant capacity and modulate the genotoxicity and oxidative stress in the kidney of rats fed ochratoxin A-contaminated diet

Evidence Based Phytopharmacological Potential of Herbal Extracts in Post-Ingestion Management of Mycotoxins in Animal Models

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