Effect of Ethanolic Extract of &lt;i&gt;Salvadora Persica&lt;/i&gt; L. and it’s Chloroform Fraction in Experimentally Induced Hyperlipidemia in Rats

Iyer, Deepa; Sharma, BK; Patil, UK

doi:10.4314/njnpm.v14i1.3

Cited by 1 publication

(5 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These lipids include cholesterol, cholesterol esters, phospholipids and triglycerides. They are transported in large molecules called lipoproteins [1].…”

Section: Discussionmentioning

confidence: 99%

“…It was also shown that HDL may protect against atherosclerosis by mechanism not directly related to reverse cholesterol transport. These function include putative anti-inflammatory, anti-oxidative, platelet anti-aggregation, anti-coagulant and fibrolytic activities [11] It has been investigated that Olive oil induced hyperlipidemia (hypertriglyceridemia) in rats is by the secretion of chylomicrontriglyceride complexes from the intestine into the lymph, thereby increasing plasma triglyceride level [1]. Since the results of this study shows that the aqueous root extract of Elaeis guineensis significantly decreased plasma triglyceride levels in rats after olive oil administration, the possible mechanism of reduction of triglycerides by the extract may be by suppressing the secretion of chylomicron-triglyceride complexes into the lymph.…”

Section: Discussionmentioning

confidence: 99%

“…Animals in group 5 received atovastatin (50 mg/kg). Olive oil (5 ml/kg oral dose) was administered 30 min after drug/extract treatment [15,1]. All administrations were done orally.…”

Section: Screening For Anti-hyperlipidemic Activitymentioning

confidence: 99%

“…They are transported in the blood as part of large molecules called lipoproteins. Hyperlipidemia is a general term, it could be either high cholesterol in the blood (hypercholesterolemia), high triglycerides in the blood (hypertriglyceridemia) or it could be both [1].…”

Section: Introductionmentioning

confidence: 99%

“…Since hyperlipidemia is usually an elevated level of total cholesterol (TC), triglycerides (TG) and low density lipoprotein (LDL), and decreased level of high density lipoprotein (HDL), treatment is geared towards a reduction in the elevated LDL, TG and TC, alongside an enhancement in the diminished HDL values [1].…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Evaluation of the Anti-Hyperlipidemic Activity of the Aqueous Root Extract of <i>Elaeis Guineensis</i>, Jacq (Arecaceae)

Owolabi¹,

Anaka²,

Innih³

et al. 2014

Nigerian Journal of Natural Products and Medicine

View full text Add to dashboard Cite

Elaeis guineensis-Jacq (Arecaceae) is reported for the treatment of a variety of ailments notable amongst these are diabetes and hyperlipidemia. The present study is aimed at evaluating its anti-hyperlipedemic effect, via olive oil induced hyperlipidemia.The aqueous extract was obtained from a decoction of the roots, and later administered to olive oil loaded rats (5 ml/kg). Administration of 250 and 500 mg/kg of the extract was done 30 min before olive oil administration. Distilled water was used as control, while atorvastatin (50 mg/kg) was the standard drug. All administrations were done orally. Blood samples were withdrawn via the abdominal aorta 2 and 4 h after olive oil administration and centrifuged at 3000 rpm for 15 to 20 min. The plasma samples obtained were subjected to biochemical analysis for HDL, LDL, triglycerides and total cholesterol. Acute treatment with the extract points to a significant (p<0.05) reduction in total cholesterol by (35.86 and 56.32%), LDL (61.27 and 20%) and triglycerides (53.87 and 71.23%) by 250 mg/kg at the 2 nd and 4 th h respectively. At the 500 mg/kg dose, a significant reduction (p<0.05) was also obtained in TC by (36.88 and 34.84%), TG (69.51 and 51.77%) and LDL (66.19 and 50%) at the 2 nd and 4 th h respectively. While a significant increase (p<0.0001) at both doses of the extract was noted for the HDL by (295.29 and 6.72% for 250; 309.33 and 43.21% for 500 mg/kg) at 2 nd and 4 th h respectively. The effect of the extract was noted to be more pronounced in the 2 nd h in comparison with the 4 th h. Phytochemical screening revealed the presence of alkaloids, tannins, flavonoids, terpenoids, and steroids. The plant possesses hypolipidemic effect, considering the increase and decrease in HDL and LDL respectively and thus a useful remedy for hyperlipdemia

show abstract

“…These lipids include cholesterol, cholesterol esters, phospholipids and triglycerides. They are transported in large molecules called lipoproteins [1].…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…Animals in group 5 received atovastatin (50 mg/kg). Olive oil (5 ml/kg oral dose) was administered 30 min after drug/extract treatment [15,1]. All administrations were done orally.…”

Section: Screening For Anti-hyperlipidemic Activitymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations