Effect of estrogens on skin aging and the potential role of SERMs

Stevenson, Susan C.; Thornton, M. Julie

doi:10.2147/cia.s798

Cited by 126 publications

(42 citation statements)

References 140 publications

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“…Further, the analysis of skin atrophy induced by chronic topical FA showed higher sensitivity of female mice to atrophic effects of lower FA doses. This was rather unexpected in view of protective anti-atrophic effects of estrogen in naturally aging skin mostly studied in postmenopausal women [19,33].…”

Section: Discussionmentioning

confidence: 98%

Sexual dimorphism in atrophic effects of topical glucocorticoids is driven by differential regulation of atrophogene REDD1 in male and female skin

et al. 2020

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Topical glucocorticoids, well-known anti-inflammatory drugs, induce multiple adverse effects, including skin atrophy. The sex-specific effects of systemic glucocorticoids are known, but sexual dimorphism of therapeutic and side effects of topical steroids has not been studied. We report here that female and male mice were equally sensitive to the anti-inflammatory effect of glucocorticoid fluocinolone acetonide (FA) in ear edema test. At the same time, females were more sensitive to FA-induced skin atrophy. We recently reported that REDD1 (regulated in development and DNA damage 1) plays central role in steroid atrophy. We found that REDD1 was more efficiently activated by FA in females, and that REDD1 knockout significantly protected female but not male mice from skin atrophy. Studies using human keratinocytes revealed that both estradiol and FA induced REDD1 mRNA/protein expression, and cooperated when they were combined at low doses. Chromatin immunoprecipitation analysis confirmed that REDD1 is an estrogen receptor (ER) target gene with multiple estrogen response elements in its promoter. Moreover, experiments with GR and ER inhibitors suggested that REDD1 induction by these hormones was interdependent on functional activity of both receptors. Overall, our results are important for the development of safer GR-targeted therapies suited for female and male dermatological patients.

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Section: Discussionmentioning

confidence: 98%

Sexual dimorphism in atrophic effects of topical glucocorticoids is driven by differential regulation of atrophogene REDD1 in male and female skin

et al. 2020

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“…In particular, TNF-α is elevated in humans that are predisposed to chronic wounds and has been identified as a therapeutic target for impaired wound healing in the elderly (Ashcroft et al, 2012[ 13 ]). Both systemic and topical estrogen treatments enhance wound healing in elderly men and women by stimulating re-epithelialization, angiogenesis, matrix deposition and wound contraction whilst dampening the inflammatory response and expression of pro-inflammatory cytokines and proteolytic mediators (Ashcroft et al, 1997[ 8 ]; Ashcroft and Ashworth, 2003[ 7 ]; Thornton, 2013[ 145 ]; Archer, 2012[ 5 ]; Stevenson and Thornton, 2007[ 136 ]).…”

Section: Estrogen and Wound Healingmentioning

confidence: 99%

Estrogen deficiency - a central paradigm in age-related impaired healing?

Mohtadi

Whitehead

Dempsey-Hibbert

et al. 2021

EXCLI Journal; 20:Doc99; ISSN 1611-2156

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“…Scientific studies have shown the positive effects of estrogen skin on regeneration. It also decreases the aging process [32,33]. However, the use of such compounds has been banned because they caused too many side effects, unlike their plant counterparts [34].…”

Section: Phytohormonesmentioning

confidence: 99%

Plant stem cells culture — a new tool for skin protection and regeneration

Kaźmierski

Roszkowski

2019

Medical Research Journal

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Development of biotechnology, esthetic medicine and cosmetology can enable us to slow down or delay the skin aging process. Currently, much attention is aimed at treatments using substances of plant origin. They have been proven to exhibit antioxidant, antibacterial and antifungal properties, accelerate wound healing, moisturize the skin, enhance skin renewal processes and protect skin against UV radiation. Biologically active plant-derived compounds, however, are often produced by plants in very small amounts. A solution to this problem is an in vitro culture of callus tissue, representing plant stem cells. Both, in vitro and in vivo studies demonstrated beneficial effects of plants stem cell extracts on human skin in the battle against ageing. The aim of this paper was to provide a review of studies based on the use of plant stem cells in limiting skin ageing.

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Effect of estrogens on skin aging and the potential role of SERMs

Cited by 126 publications

References 140 publications

Sexual dimorphism in atrophic effects of topical glucocorticoids is driven by differential regulation of atrophogene REDD1 in male and female skin

Sexual dimorphism in atrophic effects of topical glucocorticoids is driven by differential regulation of atrophogene REDD1 in male and female skin

Estrogen deficiency - a central paradigm in age-related impaired healing?

Plant stem cells culture — a new tool for skin protection and regeneration

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