Effect of Estrogen Replacement Therapy on Hepatic Triglyceride Lipase, Lipoprotein Lipase and Lipids Including Apolipoprotein E in Climacteric and Elderly Women.

Urabe, Mamoru; Yamamoto, Takara; Kashiwagi, Tomohiro; Okubo, Tomoharu; Iwasa, Kinuko; Kikuchi, Noriko; Yokota, Kazuaki; Hosokawa, Kiyohito; Honjo, Hideo

doi:10.1507/endocrj.43.737

Cited by 36 publications

(18 citation statements)

References 21 publications

(15 reference statements)

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“…Low testosterone levels increase fat mass and decrease lean muscle, causing insulin resistance and hyperlipidemia (42). Also, the plasma triglyceride clearance may decrease due to the reduced testosterone/estrogen ratio (43). However, the majority of the reports about the association between MS and Metabolic Syndrome Figure 1 The prevalence of the components of metabolic syndrome in patients and healthy controls given as % (n).…”

Section: Discussionmentioning

confidence: 99%

Metabolic syndrome and the effect of testosterone treatment in young men with congenital hypogonadotropic hypogonadism

Sönmez¹,

Haymana²,

Bolu³

et al. 2011

European Journal of Endocrinology

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Objective: The relationship between metabolic syndrome (MS) and hypogonadism has always been investigated in study groups confounded with aging, obesity or chronic metabolic disorders. So far, there has been no data about the presence of MS in young hypogonadal patients. Also, there is controversial data about the metabolic effects of testosterone replacement therapy. We investigated the frequency of MS in treatment-naïve, young men with congenital hypogonadal hypogonadism (CHH). We also searched for the effect of testosterone replacement on the metabolic profiles of this specific patient group. Design: Retrospective analysis. Methods: A total of 332 patients (age 21.68G2.09 years) were enrolled. The control group included 395 age-and body mass index (BMI)-matched healthy young men (age 21.39G1.49 years). Standard regimen of testosterone esters (250 mg/3 weeks) was given to 208 patients. Results: MS was more prevalent in CHH (P!0.001) according to healthy controls. The patients had higher arterial blood pressure, waist circumference (WC), triglyceride (P!0.001 for all), fasting glucose (PZ0.02), fasting insulin (PZ0.004), homeostatic model assessment of insulin resistance (HOMA-IR) (PZ0.002) and lower high density lipoprotein (HDL) cholesterol (P!0.001) levels. After 5.63G2.6 months of testosterone treatment, the BMI, WC (P!0.001 for both), systolic blood pressure (PZ0.002) and triglyceride level (PZ0.04) were increased and the total and HDL cholesterol levels were decreased (PZ0.02 and P!0.001 respectively). Conclusions: This study shows increased prevalence of MS and unfavorable effects of testosterone replacement in young patients with CHH. Long-term follow-up studies are warranted to investigate the cardiovascular safety of testosterone treatment in this specific population.

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Section: Discussionmentioning

confidence: 99%

Metabolic syndrome and the effect of testosterone treatment in young men with congenital hypogonadotropic hypogonadism

Sönmez¹,

Haymana²,

Bolu³

et al. 2011

European Journal of Endocrinology

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“…metabolism since estrogens have been found to decrease serum cholesterol and apo E levels (Urabe et al, 1996) concentrations (Xu et al, 1998).…”

Section: Accepted M Manuscriptmentioning

confidence: 99%

Skin and brain age together: The role of hormones in the ageing process

Makrantonaki

Schönknecht

Hossini

et al. 2010

Experimental Gerontology

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The importance of the endocrine environment in the initiation of the ageing process has been elucidated in several in vivo an in vitro studies. Changes in endocrine pathways accompany healthy ageing, these include the growth hormone /insulin like growth factor-I axis (somatopause) and that of sexual hormones, namely estradiol (menopause), testosterone (andropause), and dehydroepiandrosterone and its sulphate (adrenopause). The clinical significance of these changes is variable and results in morphological and functional alterations of all organ systems including the skin and the central nervous system. Moreover, the pathogenesis of age-associated diseases such as epithelial skin cancer and neurodegenerative diseases has been partly attributed to the lack of hormones. Several studies have been conducted in an attempt to reverse the ageing process and clinical signs by substitution of the serum hormone levels in older individuals, however the benefits of hormone replacement therapy, if any, are still controversial. On the other hand, recent data suggest that skin is a window to the human organism and represents an adequate model for ageing research, also implying the use of skin samples for evaluating the ageing status of the central nervous system.

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“…Activation of nitro-oxygen synthetase follows the increase of intracellular calcium and induces intracellular peroxidation [1]. The serum apo E level is markedly suppressed with estrogen therapy [2]. Apo E has been reported to induce precipitation of amyloid dose-dependently [3].…”

Section: Introductionmentioning

confidence: 99%