Effect of Estrogen on Th1, Th2 and Th17 Cytokines Production by Proteolipid Protein and PHA Activated Peripheral Blood Mononuclear Cells Isolated from Multiple Sclerosis Patients

Javadian, Ani; Salehi, Elham; Bidad, Katayon; Sahraian, Mohammad Ali; Izad, Maryam

doi:10.1016/j.arcmed.2014.01.002

Cited by 27 publications

(23 citation statements)

References 31 publications

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“…This assumption may be supported by the results showing that postmenopausal women had higher levels of IL-10, TNF-α and IL-1β [17] and the synthesis of certain cytokines may be regulated by sex hormones. It has been shown that estrogens may modify the production of Th1, Th2 and Th17 cytokines by peripheral blood mononuclear cells [18]. Additionally, the release of the cytokines IL-2, IL-6, IL-10, IL-12, and IL-13 may be dependant on testosterone [19].…”

Section: Discussionmentioning

confidence: 99%

Increased plasma concentrations of interleukin 35 in patients with coronary artery disease

Gorzelak-Pabiś¹,

Chałubiński²,

Wojdan³

et al. 2017

aoms

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IntroductionAtherosclerosis leading to coronary artery disease (CAD) is a chronic inflammatory condition. Interleukin 35 (IL-35) released by regulatory T cells (Tregs) has been found to be associated with CAD in the Chinese population. However, nothing is known about the relation between IL-35 concentrations and cholesterol levels. The aim of the study was to assess the levels of IL-35 in CAD patients and healthy subjects from a Caucasian population, and to analyze the relationship between IL-35 and the levels of total cholesterol, low-density lipoprotein (LDL) and high-density lipoprotein (HDL) cholesterol, left ventricular ejection fraction (LVEF), sex and postmenopausal status.Material and methodsThirty-one patients with CAD and 30 healthy controls were included in the study. Levels of plasma IL-35 were analyzed by ELISA. The LVEF was assessed by transthoracic echocardiographic examination. Plasma levels of cholesterol fractions and C-reactive protein (CRP) were assessed by immunoenzymatic methods.ResultsThe CAD patients had higher levels of IL-35 as compared to healthy controls (58.1 ±16.6 pg/ml vs. 5.35 ±3.35 pg/ml; p < 0.001). IL-35 levels negatively correlated with total and LDL cholesterol concentrations (R = –0.31, p < 0.01) and positively correlated with HDL cholesterol in men (R = 0.53, p < 0.01). In women, IL-35 levels negatively correlated with LVEF (R = –0.29, p < 0.05) and positively with the duration of postmenopausal status (R = 0.55, p < 0.01).ConclusionsThese results suggest a possible association between high levels of IL-35 and CAD.

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Section: Discussionmentioning

confidence: 99%

Increased plasma concentrations of interleukin 35 in patients with coronary artery disease

Gorzelak-Pabiś¹,

Chałubiński²,

Wojdan³

et al. 2017

aoms

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“…These cells increased after OVX because of the upregulation of STAT3, ROR-ct and ROR-a and downregulation of Foxp3, which antagonizes Th17-cell differentiation. 9 In humans, a recent paper found no effect of estradiol in the secretion of IL-17 by T cells in patients affected by multiple sclerosis, 42 whereas another suggests that estradiol inhibited Th17 differentiation through downregulation of Rorgt mRNA and protein expression. 45 Nevertheless, in these studies, the effect of estradiol was evaluated in vitro on cells from patients not in menopause and in men.…”

Section: Inflammatory Diseases Immune System and Bonementioning

confidence: 99%

“…Nevertheless, some papers confirm the role of estrogen in the regulation of immune function in humans in healthy or different disease states. 41,42 In humans the effect of estrogens on the immune function has been demonstrated in the ability to modulate T-cell cytokine production, 42,43 to answer to immune stimulation, 44 whereas OVX increases T-cell activation. 5,43 Estrogen deficiency increases the number of T cells by increasing their thymic output.…”

Section: Inflammatory Diseases Immune System and Bonementioning

confidence: 99%

Osteoimmunology: from mice to humans

Sassi¹

2016

Bonekey Reports

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The immune system has been recognized as one of the most important regulators of bone turnover and its deregulation is implicated in several bone diseases such as postmenopausal osteoporosis and inflammatory bone loss; recently it has been suggested that the gut microbiota may influence bone turnover by modulation of the immune system. The study of the relationship between the immune system and bone metabolism is generally indicated under the term 'osteoimmunology'. The vast majority of these studies have been performed in animal models; however, several data have been confirmed in humans as well: this review summarizes recent data on the relationship between the immune system and bone with particular regard to the data confirmed in humans.

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“…Concentrations, similar to those in pregnancy, have caused increased production of IL-10 and reduced IL-12, IFN-γ levels and IFN-γ/IL-10 ratio. In the same concentration, estradiol has been shown to increase IL-10 secretion and decrease expression of TNF-α mRNA in proteolipid protein (PLP)-activated peripheral blood mononuclear cells isolated from healthy subjects [17].…”

Section: Sex Hormones and The Immune Systemmentioning

confidence: 99%

“…No differences in IL-10 production have been detected between women and men [10]. On the other hand, an enhancing effect of estrogen on IL-10 production has been found in T lymphocytes from patients with MS, suggesting potentially different regulatory pathways in autoimmune diseases [16,17]. Consistent with these findings are the results from experiments, showing that estradiol at 10-100 nM inhibits lipopolysaccharide (LPS)-induced TNF-α production from human peripheral blood mononuclear cells (PBMCs) but is stimulatory in the absence of LPS.…”

Section: Sex Hormones and The Immune Systemmentioning

confidence: 99%

Sex Hormones and Multiple Sclerosis

Trenova¹

2016

Trending Topics in Multiple Sclerosis

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Experimental and clinical data about the influence of sex hormones on the course of multiple sclerosis (MS) grow rapidly during the past two decades. Estrogens, progesterone, and androgens have been shown to ameliorate experimental autoimmune encephalomyelitis (EAE) in animals, and pregnancy in women is associated with a dramatic reduction in disease activity. Immunomodulatory and neuroprotective properties of sex hormones are the most probable underlying mechanisms, creating a background for testing similar hormonal treatments in humans. Several pilot studies in this field present promising results, but larger trials are necessary to identify the adverse events and to estimate precisely the place of sex steroids in multiple sclerosis therapeutic strategies.The objective of this chapter is to summarize the recent advances in the research about the effects of sex steroids in EAE and MS and to create a ground for the development of more powerful treatments in the future.

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Effect of Estrogen on Th1, Th2 and Th17 Cytokines Production by Proteolipid Protein and PHA Activated Peripheral Blood Mononuclear Cells Isolated from Multiple Sclerosis Patients

Cited by 27 publications

References 31 publications

Increased plasma concentrations of interleukin 35 in patients with coronary artery disease

Increased plasma concentrations of interleukin 35 in patients with coronary artery disease

Osteoimmunology: from mice to humans

Sex Hormones and Multiple Sclerosis

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