Osteoimmunology: from mice to humans

Sassi, Francesca

doi:10.1038/bonekey.2016.29

Cited by 25 publications

(24 citation statements)

References 62 publications

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“…Bone is primarily comprised of type I collagen which is mineralized via the deposition of apatite during its synthesis by osteoblasts. Estrogen deficiency increases osteoclast formation by increasing the levels of available pro-osteoclastogenic cytokines [210, 211]. Osteoblastic cells have been shown to secrete multiple MMPs, including MMP-2, MMP-3, MMP-8, MMP-9, MMP-13, and MT1-MMP, while MMP-9 is mainly expressed by osteoclasts [212].…”

Section: The Role Of Collagen Catabolism In Diseasementioning

confidence: 99%

Matrix metalloproteinase collagenolysis in health and disease

Amar

Smith

Fields

2017

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

164

108

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The proteolytic processing of collagen (collagenolysis) is critical in development and homeostasis, but also contributes to numerous pathologies. Mammalian interstitial collagenolytic enzymes include members of the matrix metalloproteinase (MMP) family and cathepsin K. While MMPs have long been recognized for their ability to catalyze the hydrolysis of collagen, the roles of individual MMPs in physiological and pathological collagenolysis are less defined. The use of knockout and mutant animal models, which reflect human diseases, has revealed distinct collagenolytic roles for MT1-MMP and MMP-13. A better understanding of temporal and spatial collagen processing, along with the knowledge of the specific MMP involved, will ultimately lead to more effective treatments for cancer, arthritis, cardiovascular conditions, and infectious diseases.

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Section: The Role Of Collagen Catabolism In Diseasementioning

confidence: 99%

Matrix metalloproteinase collagenolysis in health and disease

Amar

Smith

Fields

2017

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

164

108

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“…Bone marrow (BM), the principal haematopoietic organ in adults, is encased within bone, the primary function of which is to provide mechanical support and contribute to endocrine homeostasis. The bone is not just an inert site of residence for BM; they are interdependent organs that have reciprocal regulatory mechanisms throughout life [1]. Parallel functional decline in both systems is a major contributor to loss of productivity and well-being during aging [2] and disease [3,4].…”

Section: Interdependence Of Bone and Bone Marrowmentioning

confidence: 99%

Role of bone marrow macrophages in controlling homeostasis and repair in bone and bone marrow niches

Kaur

Raggatt

Batoon

et al. 2017

Seminars in Cell & Developmental Biology

106

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Macrophages, named for their phagocytic ability, participate in homeostasis, tissue regeneration and inflammatory responses. Bone and adjacent marrow contain multiple functionally unique resident tissue macrophage subsets which maintain and regulate anatomically distinct niche environments within these interconnected tissues. Three subsets of bone-bone marrow resident tissue macrophages have been characterised; erythroblastic island macrophages, haematopoietic stem cell niche macrophages and osteal macrophages. The role of these macrophages in controlling homeostasis and repair in bone and bone marrow niches is reviewed in detail.

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“…the convergence of cells and cytokines that regulate both the immunity that the bone, causing osteoporosis [33,34]. The inflammatory cytokines TNF-α, IL-1, IL-6 and IL-17 are crucial in acute and chronic inflammation and strong inducers of bone resorption.…”

Section: Crosstalk Between the Immune And Bone System: The Immunoskelmentioning

confidence: 99%

Osteoimmunology and Beyond

Ginaldi

Martinis²

2016

CMC

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ObjectiveOsteoimmunology investigates interactions between skeleton and immune system. In the light of recent discoveries in this field, a new reading register of osteoporosis is actually emerging, in which bone and immune cells are strictly interconnected. Osteoporosis could therefore be considered a chronic immune mediated disease which shares with other age related disorders a common inflammatory background. Here, we highlight these recent discoveries and the new landscape that is emerging.MethodExtensive literature search in PubMed central.ResultsWhile the inflammatory nature of osteoporosis has been clearly recognized, other interesting aspects of osteoimmunology are currently emerging. In addition, mounting evidence indicates that the immunoskeletal interface is involved in the regulation of important body functions beyond bone remodeling. Bone cells take part with cells of the immune system in various immunological functions, configuring a real expanded immune system, and are therefore variously involved not only as target but also as main actors in various pathological conditions affecting primarily the immune system, such as autoimmunity and immune deficiencies, as well as in aging, menopause and other diseases sharing an inflammatory background.ConclusionThe review highlights the complexity of interwoven pathways and shared mechanisms of the crosstalk between the immune and bone systems. More interestingly, the interdisciplinary field of osteoimmunology is now expanding beyond bone and immune cells, defining new homeostatic networks in which other organs and systems are functionally interconnected. Therefore, the correct skeletal integrity maintenance may be also relevant to other functions outside its involvement in bone mineral homeostasis, hemopoiesis and immunity.

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Osteoimmunology: from mice to humans

Cited by 25 publications

References 62 publications

Matrix metalloproteinase collagenolysis in health and disease

Matrix metalloproteinase collagenolysis in health and disease

Role of bone marrow macrophages in controlling homeostasis and repair in bone and bone marrow niches

Osteoimmunology and Beyond

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