Effect of estradiol valerate on the pregnancy rate in patients receiving letrozole for induction of ovulation

Alnemr, Amr Abd Almohsen; Ammar, Islam Mohamed Magdi; Aboelfath, Amr Mostafa Kamel; Talaat, Bassem

doi:10.1016/j.mefs.2017.09.009

Cited by 2 publications

(4 citation statements)

References 22 publications

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“…Mean duration of infertility and BMI were not statistically significant (p>0.05) between two groups. This was similar to the findings of the studies conducted by Alnemr et al and Sarhan et al 11,15 The present study found the mean serum FSH, LH, LH/FSH ratio and serum testosterone were not statistically significant (p>0.05) between two groups. In a study done by Sarhan et al 15 had observed that mean FSH and LH were not statistically significant between two groups.…”

Section: Discussionsupporting

confidence: 93%

“…In a randomized controlled study conducted by Alnemr et al, where they included 273 patients who underwent ovulation induction and timed intercourse. 11 Patients were divided into 2 groups: controlled ovarian stimulation was done in group 1 by letrozole with addition of estradiol valerate and in group 2 by letrozole alone. They found that the number of cases reaching mature follicular size during the study period, there was no statistically significant differences (p>0.05) between the 2 studied groups (61.1% compared to 60.4%).…”

Section: Discussionmentioning

confidence: 99%

“…10 The first letrozole treatment with estradiol valerate in PCOS pt was randomized controlled study which was designed and shown that endometrial thickness and pregnancy rate is significantly higher in letrozole/estradiol valerate combination than with letrozole alone. 11 So, the aim of the study was to find the most effective drug or drugs combination especially use of estradiol valerate to improve the endometrial thickness in infertile women with PCOS.…”

Section: Introductionmentioning

confidence: 99%

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Effect of estradiol valerate on endometrial thickness in polycystic ovary syndrome having ovulation induction with letrozole

Yasmin

Banu

Akhter

et al. 2023

Int J Reprod Contracept Obstet Gynecol

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Background: PCOS is a common endocrine disorder in women of reproductive age. Letrozole is an orally active aromatase inhibitor and as effective as chlomiphene citrate for induction of ovulation. Estrogen is important in the regeneration and growth of the endometrium prior to ovulation prepare the tissue to respond to progesterone post ovulation in PCOS patients. Aim of the study was to assess the effects of estradiol valerate on endometrial thickness in PCOS having ovulation induction with letrozole. Methods: This randomized controlled study was conducted in the department of reproductive endocrinology and infertility, BSMMU, Dhaka, with 1 year duration. A total 80 diagnosed cases of PCOS patients with subfertility were included in this study. Among them 40 patients received letrozole and estradiol valerate and 40 patients received letrozole and placebo. Results: On day 8, mean endometrial thickness was not statistically significant between two groups (p=0.436). On day of triggering, mean endometrial thickness was significantly higher in intervention group 9.2±1.4 mm than control group 8.2±1.4 mm (p=0.004). Mean changes of endometrial thickness on day of triggering compared with on day 8 was significantly higher in intervention group 3.2±1.5 mm than control group 2.5±1.6 mm (p=0.043). Pregnancy rate was higher in intervention group 13 (38.2%) than control group 8 (22.2%) with relative risk 1.72, 95% CI (0.82-3.63%), that was not statistically significant between two groups (p=0.144). Conclusions: Mean changes of endometrial thickness on day of triggering were significantly higher in intervention group than control group. The pregnancy rate achieved with letrozole+estradiol valerate combination was higher than that achieved with letrozole and placebo group.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effect of estradiol valerate on endometrial thickness in polycystic ovary syndrome having ovulation induction with letrozole

Yasmin

Banu

Akhter

et al. 2023

Int J Reprod Contracept Obstet Gynecol

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“…In the present study, the median endometrial thickness in the estrogen/CC group was significantly higher than in the sildenafil/CC and control groups. Such a finding was in accordance with a previous study that showed an increase in endometrium thickness upon using exogenous estradiol in combination with letrozole compared to letrozole alone in the treatment of women undergoing ovulation induction and timed intercourse [ 31 ]. This effect was previously explained by Groothuis and colleagues, who investigated the impact of exogenous estradiol on the endometrium of mice and humans.…”

Section: Discussionsupporting

confidence: 92%

Comparative Evaluation of Sildenafil Citrate and Estrogen as an Adjuvant Therapy for Treatment of Unexplained Infertility in Women

Altyar

Boshra

Warda

et al. 2023

JPM

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Background: Uterine blood flow determines endometrial thickness. This study examined how vaginal sildenafil citrate and estradiol valerate altered endometrial thickness, blood flow, and fertility in infertile women. Methods: This study observed 148 infertile women whose infertility was unexplained. Group 1 comprised 48 patients who received oral estradiol valerate (Cyclo-Progynova 2 mg/12 h white tablets) from day 6 till ovulation was initiated with clomiphene citrate. A number of 50 participants in group 2 received oral sildenafil (Respatio 20 mg/12 h film-coated tablets) for 5 days starting the day after their previous menstrual period and finishing on the day they ovulated with clomiphene citrate. Group 3 was the control group, with 50 patients receiving clomiphene citrate (Technovula 50 mg/12 h tablets) ovulation induction from the 2nd to 7th day of cycle. All patients had transvaginal ultrasounds to determine ovulation, follicle count, and fertility. Miscarriage, ectopic pregnancy, and multiple pregnancies were monitored for three months. Results: The three groups’ mean ETs differed statistically at p = 0.0004. A statistically significant difference was found between the three groups in terms of the number of follicles, with 69% of patients in group 1 having one and 31% having two or more, 76% of patients in group 2 having one and 24% having two or more, and 90% of patients in the control group having one and 10% having two or more (p = 0.038). The clinical pregnancy rates of the three groups were 58%, 46%, and 27%, respectively (p = 0.005). The distribution of all side effects was not statistically different between the three groups. Conclusion: It is possible to claim that adding oral estrogen to clomiphene citrate therapy as an adjuvant therapy can improve endometrial thickness and, as a result, increase the pregnancy rates in unexplained infertility compared to sildenafil, especially in cases where the infertility has lasted less than two years. Most people who take sildenafil end up with a mild headache.

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Effect of estradiol valerate on the pregnancy rate in patients receiving letrozole for induction of ovulation

Cited by 2 publications

References 22 publications

Effect of estradiol valerate on endometrial thickness in polycystic ovary syndrome having ovulation induction with letrozole

Effect of estradiol valerate on endometrial thickness in polycystic ovary syndrome having ovulation induction with letrozole

Comparative Evaluation of Sildenafil Citrate and Estrogen as an Adjuvant Therapy for Treatment of Unexplained Infertility in Women

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