Effect of estradiol on oocyte development

Bianco, Katherine; Mahutte, Neal G.; Arıcı, Aydın; Sakkas, Denny; Taylor, Hugh S.

doi:10.1016/j.ijgo.2008.10.015

Cited by 11 publications

(9 citation statements)

References 24 publications

(49 reference statements)

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“…1 Our in vivo study showed that methionine supplementation increased the serum levels of E 2 and PGE 2 and decreased the serum P 4 level during estrus. Similarly, an increase in plasma estradiol has been reported to increase the number of ovulations and embryos produced, 67,68 but the increase of progesterone concentration inhibits dominant follicle development and ovulation. 69 PGE 2 promotes cumulus expansion and participates in meiosis and ovulation during oocyte development.…”

Section: Discussionmentioning

confidence: 98%

Dietary methionine supplementation during the estrous cycle improves follicular development and estrogen synthesis in rats

Yang,

Li,

Cai

et al. 2024

Food Funct.

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Section: Discussionmentioning

confidence: 98%

Dietary methionine supplementation during the estrous cycle improves follicular development and estrogen synthesis in rats

Yang,

Li,

Cai

et al. 2024

Food Funct.

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“…We found that the E2 levels associated with the ideal ES on day 2 were E2 16 =3.309±189pg/ml. It has been proposed that E2>5.000 pg/ml can be considered an acceptable upper limit (Wu CH et al, 2007), while others suggest that the limit of 2.000pg/ml is neither favorable nor harmful to the outcome of IVF (Bianco K et al, 2009). An optimal range of the E2 levels during a fresh IVF-ET cycle was recently proposed to be 1000 to 3148 pg/mL, with regard to the quality of oocytes retrieved, implantation rates, as well as the incidence of LBW outcomes (Li X et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Effect of estradiol levels after hCG trigger on embryo quality, implantation, and IVF outcome, using donor ovarian stimulation protocols

Stavros¹,

Kalabalikis²,

Mavrogianni³

et al. 2022

HJOG

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In this study, we aimed at delineating the possible effect of estradiol (E2) levels on the day of β-hCG administration on the ovary by analysingthe Embryo Score (ES) of early day 2, 44hrs post insemination. Oocyte donor ovarian stimulation protocols were thus used in order to avoid any possible counteractions of E2 with the endometrium. All oocytes were microinjected and all embryo transfers were fresh.E2 and E2/oocyte correlated positively with the ES on day 2 of embryo development. In contrast, the E2 and E2/oocyte do not appear to significantly affect the implantation and clinical pregnancy rates. Furthermore, E2 levels on the day of β-hCG administration were positively associated with fast and slowly dividing embryos compared to “ideally” dividing embryos on day 2. E2 levels corresponding to the “ideal” ES (E216) on day 2 sonographically translated into 12 mature oocytes. Embryos with “ideal” ES on day 2 were positively associated with implantation and gestational sac rates, as well as lower spontaneous miscarriage rates, in comparison to the fast and slowly dividing embryos. We propose that a) ES on day 2 of embryo development, 44hrs post insemination, is a valuable prognostic marker of embryo quality in ovarian stimulation protocols and b) an ovarian stimulation protocol may most likely be successful if not more than 12 oocytes are collected, i.e. E2 levels do not exceed 3.309pg/ml or on the day of hCG administration.

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“…There has been controversy regarding the effect of higher estradiol levels on oocyte and embryo quality. In mice, higher estradiol levels were reported to have a direct toxic effect on embryo quality and development in vitro [47], however the detrimental effects of higher estradiol levels on embryo development in the human have not been proven [48,47]. Of interest, Balakier et al recorded significantly higher E 2 levels and a higher number of oocytes in cohorts that contained giant oocytes compared with controls [49].…”

Section: Discussionmentioning

confidence: 99%

Is the presence of a non-cleaved embryo on day 3 associated with poorer quality of the remaining embryos in the cohort?

Machtinger

Bormann

Ginsburg

et al. 2015

J Assist Reprod Genet

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Purpose Morphological evaluation is currently considered the single most important predictive measure for assessing embryo quality. The aim of this study was to investigate whether cycles with at least one non-cleaved embryo (i.e., a 1-cell embryo on day 3) have different outcomes compared with cycles in which all embryos had cleaved by day 3. Methods All autologous IVF/ICSI cycles with a fresh day 3 transfer and without using a gestational carrier performed at our center between 1/1/2010 and 12/31/2011 were analyzed retrospectively. Those cycles with at least one non-cleaved embryo on day 3 were compared with all other autologous cycles that had l00 % cleaved embryos performed during the study period. Results Eight hundred and forty two cycles were included. Of them, 144 cycles comprised the non-cleaved group, and 698 cycles comprised the cleaved group. Cycles in the non-cleaved group had more oocytes retrieved (15.4±7.1 vs. 12.5±7.1, p<0.001), more zygotes obtained (10.0±5.3 vs. 7.9±5.2, p= <0.001), but the embryos exhibited lower cleavage rates and higher rates of fragmentation and asymmetry compared with controls (p<0.001). However, spontaneous abortion rates, ectopic pregnancies rates as well as delivery rates were similar between the two groups.Conclusions Our results show that the presence of a noncleaved embryo on day 3 is associated with a more exuberant response to controlled ovarian stimulation as reflected by more oocytes retrieved. Despite the significant decrease in quality of the whole cohort in the non-cleaved group, implantation, delivery rates and number of embryos frozen were not adversely affected by the presence of a non-cleaved embryo.

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Effect of estradiol on oocyte development

Cited by 11 publications

References 24 publications

Dietary methionine supplementation during the estrous cycle improves follicular development and estrogen synthesis in rats

Dietary methionine supplementation during the estrous cycle improves follicular development and estrogen synthesis in rats

Effect of estradiol levels after hCG trigger on embryo quality, implantation, and IVF outcome, using donor ovarian stimulation protocols

Is the presence of a non-cleaved embryo on day 3 associated with poorer quality of the remaining embryos in the cohort?

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