Dietary methionine supplementation during the estrous cycle improves follicular development and estrogen synthesis in rats

Yang, Guangxin; Li, Siyu; Cai, Shuang; Zhou, Junyan; Ye, Qianhong; Zhang, Shihai; Chen, Fang; Wang, Fenglai; Zeng, Xiangfang

doi:10.1039/d3fo04106a

Food Funct.

2024

DOI: 10.1039/d3fo04106a

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Dietary methionine supplementation during the estrous cycle improves follicular development and estrogen synthesis in rats

Guangxin Yang,

Siyu Li,

Shuang Cai

et al.

Abstract: A follicle is an important unit for the synthesis of steroid hormones and the oocyte development and maturation in mammals.

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2024

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Exhaled breath metabolites reveal postmenopausal gut-bone cross-talk and non-invasive markers for osteoporosis

Sukul,

Fischer,

Broderius

et al. 2024

Preprint

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Menopause driven decline in estrogen exposes women to risk of osteoporosis. Detection of early onset and silent progression are keys to prevent fractures and associated burdens. In a discovery cohort of 120 postmenopausal women (aged: 49 – 90 years), we combined repeated quantitative pulse-echo ultrasonography of bone, assessment of grip strength and serum bone markers with mass-spectrometric analysis of exhaled metabolites to find breath volatile markers and quantitative cutoff levels for osteoporosis. Obtained markers and cutoffs were validated in an independent cohort of 49 age-matched women with 6 months apart seasonal follow-ups. Within the discovery cohort median concentrations (ppbV) of exhaled end-tidal dimethyl sulfide (DMS), allyl-methyl sulfide, butanethiol and butyric acid increased significantly (p≤0.005) by 45.24%, 42.83%, 38.29% and 33.66% in subjects (n=27) with bone density at high-risk of osteoporosis and fracture, when compared to subjects (n=62) with normal bone mineral density (BMD). Increased age and decreased grip strength were concomitant. All these changes were reproduced within the independent validation cohort including seasonal follow-ups. Exhaled metabolite expressions remained age independent in either cohort. Serum bone markers showed random expressions without any reproducibility. DMS exhalations even differed between patients with recent (<1 year), old and without fractures. Metabolite exhalations and BMDs were down-regulated during winter mirroring the regional climate change. ROC analysis in the discovery cohort yielded high classification accuracy (AUC=0.86) of DMS with a cutoff at 15.88 ppbV for osteoporosis, which predicted subjects at high-risk within the independent validation cohort with high (>91%) sensitivity and specificity during both follow-ups. Non-invasive analysis of exhaled DMS allowed more reliable classification of osteoporosis risk than conventional serum bone markers. We identified associations of exhaled organosulfur and short-chain fatty acid markers to bone metabolism in postmenopausal osteoporosis via a gut-bone axis.

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Exhaled breath metabolites reveal postmenopausal gut-bone cross-talk and non-invasive markers for osteoporosis

Sukul,

Fischer,

Broderius

et al. 2024

Preprint

View full text Add to dashboard Cite

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Dietary methionine supplementation during the estrous cycle improves follicular development and estrogen synthesis in rats

Abstract: A follicle is an important unit for the synthesis of steroid hormones and the oocyte development and maturation in mammals.

Cited by 1 publication

References 73 publications

Exhaled breath metabolites reveal postmenopausal gut-bone cross-talk and non-invasive markers for osteoporosis

Exhaled breath metabolites reveal postmenopausal gut-bone cross-talk and non-invasive markers for osteoporosis

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