Exhaled breath metabolites reveal postmenopausal gut-bone cross-talk and non-invasive markers for osteoporosis
Pritam Sukul,
Dagmar-Christiane Fischer,
Celine Broderius
et al.
Abstract:Menopause driven decline in estrogen exposes women to risk of osteoporosis. Detection of early onset and silent progression are keys to prevent fractures and associated burdens. In a discovery cohort of 120 postmenopausal women (aged: 49 – 90 years), we combined repeated quantitative pulse-echo ultrasonography of bone, assessment of grip strength and serum bone markers with mass-spectrometric analysis of exhaled metabolites to find breath volatile markers and quantitative cutoff levels for osteoporosis. Obtain… Show more
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