Effect of Essential Fatty Acids on the Fatty Acid Synthesis in Epididymal Fat Cells of the Rat

Du, Julie T.; Kruger, Fred A.

doi:10.1093/jn/102.8.1033

Cited by 23 publications

(6 citation statements)

References 24 publications

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“…Such diets also occasion enhanced rates of lipogenesis in the animals and induce the accumulation of iipid in the liver (5,6). Supplementation of these high carbohydrate diets with fat, particularly fat containing linoleic acid, restores fatty acid synthesis (and presumably A9-desaturase activity) and the relative proportions of fatty acids in tissue lipids to values similar to those found in rats fed on stock diets (4)(5)(6)(7)(8)(9)(10).…”

Section: Introductionmentioning

confidence: 84%

“…It has been suggested that polyunsaturated fatty acids, particularly those possessing the 606 configuration have a specific regulatory effect, both in vivo and in vitro, on fatty acid synthesis and on A9-desaturase activity in nonobese strains of mice and rats (4)(5)(6)(7)(8)(9)(10)(17)(18)(19)(20)(21). The effect on lipogenesis in vivo was also found to be independent of the level of dietary carbohydrate (18), an observation that is at variance with a previous suggestion that the effects were due mainly to the decreased proportions of carbohydrate in diets which had been supplemented with fat (22).…”

Section: Discussionmentioning

confidence: 99%

“…The finding that the proportions of 20:46o6 increased with increased 18:2r in liver iipids of obese rats, but not in those of lean animals, is indicative of differences in the metabolism of 18:26o6 between the two phenotypes. The proportions of 18:2 and 20:46o6 fatty acids in the liver of obese rats may be involved, in part, in the aetiology of the abnormal lipid metabolism in these animals if, as has been postulated, these acids have a specific regulatory function in lipogenic tissues (4)(5)(6)(7)(8)(9)(10)(17)(18)(19)(20)(21). In conclusion, it is apparent that the hepatic lipogenesis and desaturase activity in obese rats can be modified by increased dietary sunflowerseed oil in the same way as in lean rats, despite the genetically-determined abnormal lipid metabolism in the obese animals.…”

Section: Discussionmentioning

confidence: 99%

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Effect of a diet rich in sunflower oil on aspects of lipid metabolism in the genetically‐obese rat

Wahle¹,

Radcliffe²

1977

Lipids

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Aspects of the lipid metabolism of male, obese and lean Zucker rats were compared using animals which had been fed ad libitum for 32 days on a diet (HS) which contained 200 g sunflowerseed oil/kg or one (LS) which contained 50 g/kg of the oil. When compared with the LS diet, the HS diet decreased the characteristic lipid accretion in the liver of obses rats from 126 mg (LS) to 81 mg (HS)/g wet weight; corresponding values for the lean rats were 39 mg and 56 mg/g wet weight of liver, respectively. The HS diet depressed lipid synthesis de novo by liver homogenates and decreased the delta9-desaturase activity of liver microsomes from obese and lean rats by about 50%. delta9-Desaturase activity in vitro was also depressed by the addition of linoleic acid to liver microsomes from both obese and lean rats fed ad libitum on a standard laboratory diet. Depressed delta9-desaturase activity, due to ingestion of the HS diet, was reflected in lower ratios of 16:1/16:0 and 18:1/18:0 fatty acids in tissue lipids from obese and lean rats. Ingestion of the HS compared with the LS diet resulted in increased proportions of 18:2omega6 in liver lipids and adipose tissue triacylglycerols of obese and lean rats. The HS diet also increased the proportions of 20:4omega6 in adipose triacylglycerols of obese and lean rats and in liver lipids of obese animals but not in their lean littermates.

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Section: Introductionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Effect of a diet rich in sunflower oil on aspects of lipid metabolism in the genetically‐obese rat

Wahle¹,

Radcliffe²

1977

Lipids

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“…It is well known that high fat diets reduce the rate of mammalian lipogenesis. Studies with rodents also have shown that diets supplemented with linoleic acid (usually given as safflower oil) resulted in a significantly greater inhibition of the rate of lipogenesis in adipose tissue and liver slices than diets containing equivalent amounts of saturated fatty acids (6)(7)(8)(9)(10)(11)(12)(13)(14). The mechanism by which linoleic acid exerts its extra-inhibitory effect upon the rate of lipogenesis is unknown.…”

Section: Introductionmentioning

confidence: 99%

Effect of dietary safflower oil upon lipogenesis in neonatal lamb

Vernon

1975

Lipids

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The effect of dietary safflower oil upon lipogenesis has been investigated in neonatal lambs. Preliminary experiments with lambs suckled by their mothers showed that there was a 10-fold increase in the rate of incorporation of [14-C] from acetate into fatty acids in adipose tissue slices during the first 10 days post partum. Barely detectable rates of [14-C] acetate incorporation into fatty acids were found in liver slices from lambs during the same period. In lambs given cows' milk from birth untill 11 days of age, there was also a 10-fold increase in the rate of lipogenesis in adipose tissue slices. Supplementing the diet of cows' milk with safflower oil (5 ml/lamb/day) resulted in significantly lower rates of lipogenesis in adipose tissue slices from 11 day old lambs. Administration of safflower oil had no effect upon the concentration of unesterified fatty acids, including linoleic acid, in the lamb adipose tissue slices. The data show that lipogenesis in ovine adipose tissue, like that in rodent liver and adipose tissue, is sensitive to dietary polyunsaturated fatty acids, and that, for the neonatal lamb, the effect of polyunsaturated fatty acids upon lipogenesis is not dependent upon an increase in the tissue concentration of polyunsaturated fatty acids.

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“…In the liver, de novo fatty acid synthesis has been shown to be inhibited by essential fatty acids (EFA) (Sabine et al 1969;Bartley & Abraham, 1972;Du & Kruger, 1972;Jeffcoat et al 1979). Fatty acids from both families of EFA (n-6, n-3) appear to have similar effects in this regard without preference for either the chain length or number of double bonds in the fatty acid (Chu et al 1969;Muto & Gibson, 1969, 1970Wahle & Radcliffe, 1977;Schwarz & Abraham, 1982).…”

mentioning

confidence: 99%

Essential fatty acids in the liver and adipose tissue of genetically obese mice: effect of supplemental linoleic and γ-linolenic acids

Cunnane¹,

Manku²,

Horrobin³

1985

Br J Nutr

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1. Genetically obese mice (ob/ob) and their lean litter-mates were given diets iso-energetically supplemented with sucrose, hydrogenated coconut oil, safflower oil or evening primrose (Oenothera biennis) oil.2. Weight gain over 15 weeks was significantly greater in the evening primrose oil-supplemented obese mice than in the other groups.3. In all the groups of obese mice, liver total phospholipids contained proportionally less linoleic acid and more dihomo-γ-linolenic acid and arachidonic acid than did the lean controls.4. As a percentage of total fatty acids, n-3 essential fatty acids (EFA) in liver and adipose tissue lipids were significantly lower in the obese mice than in the lean controls.5. Supplementation with EFA-rich oils (safflower and evening primrose oil) increased the proportional composition of n-6 EFA and decreased the n-3 EFA more in the liver total phospholipids of the lean than the obese mice.

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Effect of Essential Fatty Acids on the Fatty Acid Synthesis in Epididymal Fat Cells of the Rat

Cited by 23 publications

References 24 publications

Effect of a diet rich in sunflower oil on aspects of lipid metabolism in the genetically‐obese rat

Effect of a diet rich in sunflower oil on aspects of lipid metabolism in the genetically‐obese rat

Effect of dietary safflower oil upon lipogenesis in neonatal lamb

Essential fatty acids in the liver and adipose tissue of genetically obese mice: effect of supplemental linoleic and γ-linolenic acids

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