Effect of Essential Amino Acid Restriction on the Growth of Female C57BL Mice and Their Implanted BW10232 Adenocarcinomas

Theuer, Richard C.; Kissel, John D.

doi:10.1093/jn/101.2.223

Cited by 75 publications

(60 citation statements)

References 12 publications

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“…Our results indicate that the viability was not affected by nonessentials amino acids as has been reported before with mice feds deficient tryptophan tumoral cells [20][21][22]. On the other hand, a decrease in the viability has been reported in rat brain postmitotic neurons depleted in tryptophan, isoleucin, metionin and cholin [23].…”

Section: Discussionsupporting

confidence: 86%

Embryoprotein TWIST distribution in breast cancer cells MDA-MB-231 treated with 5-Fluorouracil and malnutrition

Escobar-Cabrera¹,

Rodríguez-Torres²,

Berumen³

et al. 2011

JBiSE

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TWIST is a transcription factor that belongs to the family of helix-loop-helix proteins involved in metastasis with essential role regulating cell movement during early development, as well as in the tumor progression and metastasis of many cancers including breast cancer. It will be interesting to study the relation among cancer chemotherapy, malnutrition and the transcription factors like TWIST in order to explore the risk to metastasis. We used breast cancer line MDA-MB-231. Cell cultures were treated with 5-Fluorouracil (5-Fu), as well as changes in serum and nonessentials amino acid (NEAA), to explore the cell viability and the cellular distribution of TWIST by immunocytochemistry. Our results indicate that cell viability decreased significantly with 5-Fu treatment whereas no changes were observed in malnutrition treatment. On the other hand, TWIST protein significantly increased its distribution in cytoplasm of treated groups with malnutrition as well as in those treated with 5-Fu compared with the control. These results suggest that TWIST translocation was modified by the treatments and further studies are necessary to suggest that TWIST could be a tag protein to avoid metastasis.

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Section: Discussionsupporting

confidence: 86%

Embryoprotein TWIST distribution in breast cancer cells MDA-MB-231 treated with 5-Fluorouracil and malnutrition

Escobar-Cabrera¹,

Rodríguez-Torres²,

Berumen³

et al. 2011

JBiSE

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“…Экспериментальные результаты использования безметионинового рациона для торможения роста опухоли свидетельствуют о перспективности этого подхода, но длительный дефицит метионина и его предшественников может оказаться летальным [91]. Ограничение содержания метионина в рационе на 40 % у самцов крыс Wistar уменьшает концентрацию активных форм кислорода в головном мозге и мито-хондриях почек без снижения массы тела, в то время как 80%-е сокращение уровня метионина приводит к существенной потере массы тела [92].…”

Section: возможность использования рациона со сниженным содержанием мunclassified

Pathological Metabolism of Methionine in Malignant Cells Is a Potential Target for the Antitumor Therapy

VS¹,

Davydov²,

Anufrieva³

et al. 2017

Клиническая онкогематология

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This review presents the characteristics of the cellular metabolism of methionine, as well as known data on the mechanisms of the development of methionine dependence in malignant cells. The possibilities of using a non-methionine diet for the control of the tumor growth in patients with various forms of cancer are considered. The information about methionine Y-lyase, an enzyme providing elimination of methionine from plasma, is provided. Its role as a potential antitumor enzyme is disclosed. Data on cytotoxic activity of the enzyme, obtained from various sources, and information on tumor models and cell cultures, showing methionine dependence are summarised.

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“…In animal studies, the growth of tumor was inhibited when the tumor-bearing animals were fed an L-methionine-lacking diet, or kept on methionine-degrading enzyme (Lmethionase) (Sugimura et al 1959;Theuer 1971; Kreis and Hession 1973;Kreis 1979). Nowadays, L-methionine-and L-cysteine-free amino acid solutions can be prepared with synthetic amino acids.…”

mentioning

confidence: 99%

Influence of L-methionine-deprived total parenteral nutrition on the tumor tissue and plasma amino acids fraction and the host metabolism: Experimental study with Sato lung carcinoma-bearing rats.

Goseki

Endo

Onodera

et al. 1989

Tohoku J. Exp. Med.

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Hospital, Tokyo 113GOsEKI, N., ENDO, M., ONODERA, T. and KOsAKI, G. Influence of LMethionine-Deprived Total Parenteral Nutrition on the Tumor Tissue and Plasma Amino Acids Fraction and the Host Metabolism : Experimental Study with Sato Lung Carcinoma-Bearing Rats. Tohoku J. Exp. Med., 1989, 157 (3), 251-260 Creation of an amino acid imbalance, particularly curtailment of L-methionine, at the tumor cell level is thought to have a favorable effect on the inhibition of tumor growth. In the present study, we examined the influence of a specially-formulated amino acid mixture, avoid of sulfur-containing amino acids (L-methionine and L-cysteine), on the growth and amino acid fraction of Sato lung carcinoma (SLC) and the host metabolism in SLC-bearing rats. The rats were treated by total parenteral nutrition containing the above amino acid mixture, plus other nutrients (methionine-deprived TPN) for 10 days. Tumor growth began to decrease 4 days after the start of this treatment and the size was significantly less at the end of the treatment than in rats receiving conventional TPN with general purpose Vuj-N type amino acid solution as a protein source. The tumor-to-carcass weight ratio also showed a similar trend. In biochemistry, the albumin level and albumin-toglobulin ratio were significantly lower than in the rats receiving conventional TPN but other parameters such as total protein, glucose, GOT and GPT were not affected by the treatment. In the amino acid fraction of the tumor tissue extraction, both L-methionine and L-tyrosine were decreased and L-serine was increased significantly compared with the control group. methionine-deprived TPN ; amino acid imbalance ; influence of methionine deprivation ; cancer therapy ; Sato lung carcinoma-bearing rat

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Effect of Essential Amino Acid Restriction on the Growth of Female C57BL Mice and Their Implanted BW10232 Adenocarcinomas

Cited by 75 publications

References 12 publications

Embryoprotein TWIST distribution in breast cancer cells MDA-MB-231 treated with 5-Fluorouracil and malnutrition

Embryoprotein TWIST distribution in breast cancer cells MDA-MB-231 treated with 5-Fluorouracil and malnutrition

Pathological Metabolism of Methionine in Malignant Cells Is a Potential Target for the Antitumor Therapy

Influence of L-methionine-deprived total parenteral nutrition on the tumor tissue and plasma amino acids fraction and the host metabolism: Experimental study with Sato lung carcinoma-bearing rats.

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