Effect of ESS on Olfactory Threshold of Patients with CRS without Nasal Polyps

Yousefi, Jaleh; Madarshahi, Hojat; Akhavan, Asghar; Taheri, Abolfazl; Saeedi, Mohsen; Bagherihagh, Ali; Hosseini, Mohammad Ali; Khosravi, Ardeshir

doi:10.5935/0946-5448.20180015

Cited by 6 publications

(8 citation statements)

References 17 publications

(20 reference statements)

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“…In a prospective, multi‐center study, CRS patients treated with ESS had better olfactory function than who were treated with medication 130 . in contrast, some studies revealed that there were no significant differences in olfactory function between ESS and standard medical therapy groups 102,131 . These differences in outcome may be due in part to the heterogeneity in patients involved and to methods used for assessment.…”

Section: Olfaction Indicates the Degree Of Inflammation And May Be A mentioning

confidence: 96%

“…However, as discussed above, subjective and objective testing have been shown to correlate poorly—with subjective ratings being confounded by numerous factors including nasal airflow and the patients expectations 27 . Yousefi et al's study revealed there are not significantly improvement in olfactory threshold among 16 CRSsNP patients after 3 months topical corticosteroids and nasal irrigation of normal saline ( P = .311 for men and P = .139 for women) 102 …”

Section: Olfaction Indicates the Degree Of Inflammation And May Be A mentioning

confidence: 99%

“…130 in contrast, some studies revealed that there were no significant differences in olfactory function between ESS and standard medical therapy groups. 102,131 These differences in outcome may be due in part to the heterogeneity in patients involved and to methods used for assessment. Further studies involving larger samples of participants and more sensitive, unified measures of olfaction are required.…”

Section: Conservative Approachesmentioning

confidence: 99%

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Olfaction: Sensitive indicator of inflammatory burden in chronic rhinosinusitis

Xing

Whitcroft

Hummel

2020

Laryngoscope Investig Oto

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Background and Objective: Olfactory dysfunction has a high prevalence in chronic rhinosinusitis (CRS) patients and significantly affects quality of life. CRS is recognized as a complex disorder encompassing heterogeneous inflammatory processes in the nose and paranasal sinuses. Olfactory dysfunction in CRS patients is associated with the level of inflammatory mediators and the efficiency of inflammatory control. Learning about the association between CRS-related inflammation and olfactory function will provide clues to the pathogenesis of CRS. Structure: The first section of this review describes the assessment of olfactory function using various measures, from ratings to MR based imaging. Then, we discuss the conductive and inflammatory mechanisms related to olfactory dysfunction in CRS: olfaction is associated with certain inflammatory patterns and is potentially a marker of CRS subtype. Finally, we review anti-inflammatory therapies including conservative and surgical approaches, and their effectiveness in olfactory dysfunction in CRS. Conclusion: Assessment of olfactory function should be considered in the clinical evaluation of CRS patients, not only for detecting and quantifying patients' symptom, but also because it appears to be useful to objectively assess the efficacy of CRS treatment over time. In addition, olfaction can be expected to expand the library of CRS phenotypes and endotypes and, hence, pave the way for more precise, tailored treatment options.

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Section: Olfaction Indicates the Degree Of Inflammation And May Be A mentioning

confidence: 96%

Section: Olfaction Indicates the Degree Of Inflammation And May Be A mentioning

confidence: 99%

Section: Conservative Approachesmentioning

confidence: 99%

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Olfaction: Sensitive indicator of inflammatory burden in chronic rhinosinusitis

Xing

Whitcroft

Hummel

2020

Laryngoscope Investig Oto

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“…It was shown that nasal saline irrigation was ineffective in many studies conducted on nasal saline irrigation in patients with chronic rhino-sinusitis [ 23 , 24 ]. In a meta-analysis; however, it was found that hypertonic saline irrigation was more effective in the treatment of chronic rhino-sinusitis compared to isotonic irrigation [ 25 , 26 ]. In our study, it was found that there were no significant increases in self-rating olfactory scores in patients who did irrigation with nasal saline compared to the control group.…”

Section: Discussionmentioning

confidence: 99%

Comparison of the Healing Effect of Nasal Saline Irrigation with Triamcinolone Acetonide Versus Nasal Saline Irrigation alone in COVID-19 Related Olfactory Dysfunction: A Randomized Controlled Study

Yıldız¹,

Yildiz²,

Kuzu³

et al. 2021

Indian J Otolaryngol Head Neck Surg

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There is no routinely determined treatment for olfactory dysfunction because of COVID-19. Saline irrigation and nasal corticosteroid treatments are safe and inexpensive methods, and have low side effects. In our study, we argue that saline nasal irrigation and topical corticosteroid treatment can be used in the treatment of patients with olfactory loss in all areas of rhinology. A total of 150 patients who admitted to our clinic with other symptoms or with only acute odor loss, diagnosed with COVID-19 with RT-PCR were divided into 3 equal groups.Fifty patients in Group 1 were not given any extra treatments. The other 50 patients in Group 2 were given saline irrigation for treatment; and the 50 people in Group 3 were given both saline irrigation and nasal steroid spray for treatment. The ''Subjective Olfactory Capability (SOC)'' was used for olfactory function evaluation of patients. Self-Rating Olfactory Score (SROS), and Olfactory Dysfunction Duration (ODD) were recorded on the 1st, 15th and 30th days. SROS of the group receiving Nasal Saline ? Triamcinolone Acetonide treatment on the 30th day was significantly higher than in other groups (p 21-3 = 0.018, p 223 = 0.033). Also, the ODD was significantly reduced in this group compared to other groups (p 21-3 = 0.022, p 223 = 0.028,). Topical triamcinolone treatment was found to be successful in the treatment of olfactory dysfunction due to COVID-19. Nasal steroids, which are both inexpensive and have low side effect profiles, can be used safely in the treatment of patients with olfactory losses.

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“…Nasal polyp (NP) is benign growths of the mucosa. [1–4] It is manifested that this disorder includes nasal obstruction, nasal discharge, postnasal drip, and loss of smell. [5–7] If such disorder cannot treat fairly well, it can cause recurrent nature of NP and can significant impact heath-related quality of life.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of mometasone furoate for nasal polyps

Han

Wang

et al. 2019

Medicine

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Background: This study aims to systematically explore the efficacy and safety of mometasone furoate (MTF) for patients with nasal polyps (NP). Methods: We will search MEDLINE, Cochrane Library, PubMed, Springer, Web of Science, Ovid, Wangfang and Chinese Biomedical Literature Database from their inception to April 30, 2019 without language restrictions. All randomized controlled trials (RCTs) of MTF for the treatment of NP will be considered for inclusion. RevMan 5.3 software will be used for data synthesis, subgroup analysis, sensitivity analysis, as well as the meta-analysis. Results: Primary outcomes include change in symptom scores (as measured by any symptom scores), and polyp size (as assessed by any Polyp size scores or tools). Secondary outcomes consist of polyp recurrence, change in nasal air flow, quality of life outcomes (as measured by any quality of life scales, such as Short Form Health Survey is a 36-item), and adverse events. Conclusion: This study will provide evidence for judging whether MTF is an effective and safe treatment for NP or not. PROSPERO registration number: PROSPERO CRD42019134037.

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Effect of ESS on Olfactory Threshold of Patients with CRS without Nasal Polyps

Cited by 6 publications

References 17 publications

Olfaction: Sensitive indicator of inflammatory burden in chronic rhinosinusitis

Olfaction: Sensitive indicator of inflammatory burden in chronic rhinosinusitis

Comparison of the Healing Effect of Nasal Saline Irrigation with Triamcinolone Acetonide Versus Nasal Saline Irrigation alone in COVID-19 Related Olfactory Dysfunction: A Randomized Controlled Study

Efficacy of mometasone furoate for nasal polyps

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