Effect of erythropoietin on membrane lipid peroxidation, superoxide dismutase, catalase, and glutathione peroxidase of rat RBC

Chakraborty, Munmun; Ghosal, Jharna; Biswas, Tanmay; Datta, Asoke G.

doi:10.1016/0885-4505(88)90099-0

Cited by 28 publications

(17 citation statements)

References 30 publications

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“…These studies showed that EPO increased the activity of antioxidant enzymes, such as SOD, CAT, and GSH-Px (28,29,(34)(35)(36)(37). In the present study, it also was found that rHuEPO administered prior to ischemia significantly elevated the level of CAT activity when compared with the I/R group.…”

Section: Discussionsupporting

confidence: 75%

See 1 more Smart Citation

Erythropoietin Protects the Intestine Against Ischemia/Reperfusion Injury in Rats

Güneli

Cavdar

İşlekel

et al. 2007

Mol Med

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Section: Discussionsupporting

confidence: 75%

“…Previous studies established that EPO inhibits lipid peroxidation in the oxidative damage induced by in vitro (28,29) and in vivo (17,30,31) models. These studies also established that EPO inhibited lipid peroxidation induced by strong hydroxyl radicals (·OH) formed by iron-mediated Fenton reaction.…”

Section: Discussionmentioning

confidence: 99%

Erythropoietin Protects the Intestine Against Ischemia/Reperfusion Injury in Rats

Güneli

Cavdar

İşlekel

et al. 2007

Mol Med

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“…It has also been shown that Epo possesses neuroprotective action in animal models of global and focal cerebral ischemia and spinal ischemia models in adult rodents [9,10,[15][16][17][18]. Although the exact mechanisms of the neuroprotective action of Epo is not completely known, promotion of cell survival signaling cascades [10,19], upregulation of the expression of antiapoptotic proteins [20], modulation of intracellular calcium metabolism [13], attenuation of NO production [16,21], inhibition of glutamate release [12], antiapoptotic [10,16,18], antioxidative [22,23] and anti-inflammatory [17] actions have been suggested as possible mechanisms. These properties suggest that Epo may show beneficial effects against hypoxic-ischemic insults in the neonatal brain.…”

Section: Introductionmentioning

confidence: 99%

Neuroprotective Effect of Erythropoietin on Hypoxic-Ischemic Brain Injury in Neonatal Rats

Kumral

Özer²,

Yılmaz³

et al. 2003

Neonatology

153

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Erythropoietin (Epo) prevents ischemia and hypoxia-induced neuronal death in vitro. Recent studies have shown that this cytokine also has in vivo neuroprotective effects in cerebral and spinal ischemia in adult rodents. In this study, we aimed to investigate the effect of systemically administered recombinant human Epo on infarct volume and apoptotic neuronal death in a newborn rat hypoxic-ischemic brain injury model. Our results showed that a single dose of intraperitoneal Epo treatment (1,000 U/kg) significantly decreased the mean infarct volume as compared to the control group. In contrast to the Epo-treated group, histopathological examination by positive terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling of the affected brain in control animals revealed widespread neuronal injury associated with numerous apoptotic cells. Morphometric analysis to determine the extent of damage quantitatively ascertained that the mean infarct volume was significantly lower in the Epo-treated group (p < 0.003). These results suggest the beneficial neuroprotective effect of Epo in this model of neonatal hypoxic-ischemic brain injury. To our knowledge, this is the first study that demonstrates a protective effect of Epo against hypoxia-ischemia in the developing brain.

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“…In contrast, Fraser et al [22] showed that OrthoEB from cultured human bone marrow cells retained 30% of the initial number of EPO-R. Working with cultured Friend virus infected mouse bone marrow cells Wickrema et al [26] -ATPase activity in rat and rabbit reticulocyte membranes [29,30] and human RBC [28]; activation of nitric oxide synthase activity in murine RTC and RBC [27]; glucose transport in rat RBC [31] reactive oxygen metabolism and in rat RBC [32] and the work of Lang et al [33] who have shown that EPO can inhibit eryptosis mediated in human RBC by a wide variety of insults (reviewed in Lang et al [33]). Thus, when levels of EPO-R agonist fall, the lack of signaling by the remaining EPO-R on RTC may result in their rapid clearance via eryptosis.…”

Section: Discussionmentioning

confidence: 99%

Differential Effects of Long-lived Erythropoietin Receptor Agonists in Rats

Bugelski¹,

Makropoulos²,

Doms³

2011

Pharm Anal Acta

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Erythropoietin (EPO) regulates proliferation and differentiation of erythroid precursor cells into erythrocytes. Here, we report on experiments designed to study how the pharmacokinetic profiles of EPO receptor agonists, ranging from the short-lived epoetin-α to the long-lived EPO-MIMETIBODY TM constructs CNTO 530 and CNTO 531, influence the pharmacodynamic response in rats. Rats received a single dose of an EPO-R agonist and the effects on reticulocytes, red blood cells and hemoglobin were measured over time. The increase in red blood cells and hemoglobin were negatively correlated with clearance. At doses that cause a similar effect on reticulocytes, very long-lived EPO-R agonists caused prolonged production of red blood cells. In conclusion, we have shown that very long-lived EPO-R agonists cause prolonged production of red blood cells and increase in hemoglobin that is independent of their in vitro potency or the peak release of reticulocytes. These data suggest that EPO may be a survival factor for reticulocytes.

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Effect of erythropoietin on membrane lipid peroxidation, superoxide dismutase, catalase, and glutathione peroxidase of rat RBC

Cited by 28 publications

References 30 publications

Erythropoietin Protects the Intestine Against Ischemia/Reperfusion Injury in Rats

Erythropoietin Protects the Intestine Against Ischemia/Reperfusion Injury in Rats

Neuroprotective Effect of Erythropoietin on Hypoxic-Ischemic Brain Injury in Neonatal Rats

Differential Effects of Long-lived Erythropoietin Receptor Agonists in Rats

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