Effect of ergosta-4,6,8(14),22-tetraen-3-one (ergone) on adenine-induced chronic renal failure rat: A serum metabonomic study based on ultra performance liquid chromatography/high-sensitivity mass spectrometry coupled with MassLynx i-FIT algorithm

Targeting cancer initiating cells by promoting cell differentiation and restoring chemosensitivity via dual inactivation of STAT3 and Src activity using an active component of Antrodia cinnamomea mycelia

“…Other also demonstrate that YMGKI-2 possesses pharmacological activities in vivo and in vitro [54–57]. Together, these studies suggest that YMGKI-2 is a potential drug for disease treatment.…”

Lipidomics

“…Comprehensive understanding of its applications is critically important for lipidomics. Many studies have demonstrated that metabolic disorders or abnormalities of various lipids lead to kidney disease [96][97][98][99]. Using chronic renal failure (CRF), renal cell carcinoma (RCC), chronic glomerulonephritis, IgA nephropathy, and DN, we discuss lipidomics in kidney disease in humans and animal-and cell-model studies.…”

Neuroprotection or neurotoxicity? new insights into the effects of Acanthopanax senticosus harms on nervous system through cerebral metabolomics analysis

“…The change in the expression levels of endogenous metabolites can be used to characterize the therapeutic effects of herbal medicine (Li et al, 2013b) and assess their toxicity (Lu et al, 2013). Emerging metabolomics provides a powerful platform for monitoring multiple endogenous metabolites levels simultaneously in the samples from cell lines (Gao et al, 2014), tissues (Li et al, 2013b), and body fluids (Lu et al, 2013;Zhao et al, 2012). Metabolomics, as one of the major components of systems biology, is defined as 'the quantitative measurement of the dynamic multi-parametric metabolic response of living systems to pathophysiological stimuli or genetic modification' (Nicholson et al, 1999).…”