2008
DOI: 10.1128/jcm.02363-07
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Effect of Epstein-Barr Virus Sequence Variation on Performance of the Roche Real-Time LightCycler PCR Assay

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Cited by 4 publications
(5 citation statements)
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“…EBER staining was, however, positive in all 11. Thus, the lack of detection of EBV by qcPCR may have been secondary to technical issues with the assay (16). The median interval between the first detection of EBV by qcPCR and development of PTLD in the nine patients with detectable EBV DNA was 3.3 months (range 2.3–94.2 months), and the median interval between immunosuppressive change and development of PTLD was one month (range 2 wk–2.6 yr).…”
Section: Resultsmentioning
confidence: 99%
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“…EBER staining was, however, positive in all 11. Thus, the lack of detection of EBV by qcPCR may have been secondary to technical issues with the assay (16). The median interval between the first detection of EBV by qcPCR and development of PTLD in the nine patients with detectable EBV DNA was 3.3 months (range 2.3–94.2 months), and the median interval between immunosuppressive change and development of PTLD was one month (range 2 wk–2.6 yr).…”
Section: Resultsmentioning
confidence: 99%
“…The median interval between the first detection of EBV by qcPCR and development of PTLD in the nine patients with detectable EBV DNA was 3.3 months (range 2.3–94.2 months), and the median interval between immunosuppressive change and development of PTLD was one month (range 2 wk–2.6 yr). One recipient in Era A with monomorphic PTLD was diagnosed at the time of initial EBV DNA detection, and another with polymorphic PTLD had biopsy specimens consistent with EBV disease but undetectable EBV DNA by PCR (17). The specific changes in immunosuppression in response to the detection of EBV in the blood by PCR are detailed in Table 2.…”
Section: Resultsmentioning
confidence: 99%
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“…In immunosuppressed individuals, EBV is associated with post transplant lymphoproliferative diseases and AIDS-related lymphomas (1)(2)(3). Reliable detection and accurate monitoring of EBV DNA levels support clinical management, allowing early and tailored therapy (4)(5)(6)(7)(8)(9).…”
Section: Introductionmentioning
confidence: 99%
“…Today, molecular assays for detection and quantitation of EBV DNA have been implemented in the routine diagnostic laboratory and have replaced serological testing, especially for immunosuppressed patients (4)(5)(6)(7)(8)(9)(10). Molecular assays based on detection of EBV DNA from whole blood or plasma allow for rapid diagnosis of established EBV infections (4,6,11).…”
Section: Introductionmentioning
confidence: 99%