Effect of environmental factors on the complexation of iron and humic acid

Fang, Kai; Yuan, Dongxing; Zhang, Lei; Feng, Lifeng; Chen, Yaojin; Wang, Yuzhou

doi:10.1016/j.jes.2014.06.039

Cited by 26 publications

(11 citation statements)

References 43 publications

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“…For example, derivatives containing carboxylic acid metal ion binding sites are present in all plants and are involved in iron chelation. Among these are citrate, nicotianamine, mugineic acid, fulvic acid and humic acids (Figure 7) [71,72,73,74,75]. A typical humic acid has a variety of components including quinone, phenol, catechol and sugar moieties.…”

Section: Phytochelators With Iron Binding Propertiesmentioning

confidence: 99%

Phytochelators Intended for Clinical Use in Iron Overload, Other Diseases of Iron Imbalance and Free Radical Pathology

Kontoghiorghe¹,

Kolnagou²,

Kontoghiorghes³

2015

Molecules

104

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Iron chelating drugs are primarily and widely used in the treatment of transfusional iron overload in thalassaemia and similar conditions. Recent in vivo and clinical studies have also shown that chelators, and in particular deferiprone, can be used effectively in many conditions involving free radical damage and pathology including neurodegenerative, renal, hepatic, cardiac conditions and cancer. Many classes of phytochelators (Greek: phyto (φυτó)-plant, chele (χηλή)-claw of the crab) with differing chelating properties, including plant polyphenols resembling chelating drugs, can be developed for clinical use. The phytochelators mimosine and tropolone have been identified to be orally active and effective in animal models for the treatment of iron overload and maltol for the treatment of iron deficiency anaemia. Many critical parameters are required for the development of phytochelators for clinical use including the characterization of the therapeutic targets, ADMET, identification of the therapeutic index and risk/benefit assessment by comparison to existing therapies. Phytochelators can be developed and used as main, alternative or adjuvant therapies including combination therapies with synthetic chelators for synergistic and or complimentary therapeutic effects. The development of phytochelators is a challenging area for the introduction of new pharmaceuticals which can be used in many diseases and also in ageing. The commercial and other considerations for such development have great advantages in comparison to synthetic drugs and could also benefit millions of patients in developing countries.

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Section: Phytochelators With Iron Binding Propertiesmentioning

confidence: 99%

Phytochelators Intended for Clinical Use in Iron Overload, Other Diseases of Iron Imbalance and Free Radical Pathology

Kontoghiorghe¹,

Kolnagou²,

Kontoghiorghes³

2015

Molecules

104

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“…They also indicated that the total dissolved HS decreased as the distance from the mouth of the Mercy River increased. Moreover, they reported that the structure of HS might change as salinity increases, so IBC may be influenced by salinity 37 . The structure of HA and the Fe-HS complexation could be different in solutions of different ionic strengths 18 .…”

Section: Introductionmentioning

confidence: 99%

Capacity of humic substances to complex with iron at different salinities in the Yangtze River estuary and East China Sea

Yang

et al. 2017

Sci Rep

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The iron binding capacities (IBC) of fulvic acid (FA) and humic acid (HA) were determined in the salinity range from 5 to 40. The results indicated that IBC decreased while salinity increased. In addition, dissolved iron (dFe), FA and HA were also determined along the Yangtze River estuary’s increasing salinity gradient from 0.14 to 33. The loss rates of dFe, FA and HA in the Yangtze River estuary were up to 96%, 74%, and 67%, respectively. The decreases in dFe, FA and HA, as well as the change in IBC of humic substances (HS) along the salinity gradient in the Yangtze River estuary were all well described by a first-order exponential attenuation model: y(dFe/FA/HA, S) = a0 × exp(kS) + y0. These results indicate that flocculation of FA and HA along the salinity gradient resulted in removal of dFe. Furthermore, the exponential attenuation model described in this paper can be applied in the major estuaries of the world where most of the removal of dFe and HS occurs where freshwater and seawater mix.

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“…The effect of several factors (e.g. temperature and ionic strength) on iron-catechol complexation is currently unknown or unclear due to contradictory reports in literature 3,4,[17][18][19] . Additionally, two-way interactions between the aforementioned factors have not yet been investigated.…”

mentioning

confidence: 99%

Revealing the main factors and two-way interactions contributing to food discolouration caused by iron-catechol complexation

Bijlsma

Bruijn

Hageman

et al. 2020

Sci Rep

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Fortification of food with iron is considered to be an effective approach to counter the global health problem caused by iron deficiency. However, reactivity of iron with the catechol moiety of food phenolics leads to discolouration and impairs bioavailability. in this study, we investigated the interplay between intrinsic and extrinsic factors on food discolouration caused by iron-catechol complexation. to this end, a three-level fractional factorial design was implemented. Absorbance spectra were analysed using statistical methods, including pcA, HcA, and AnoVA. furthermore, a direct link between absorbance spectra and stoichiometry of the iron-catechol complexes was confirmed by ESI-Q-TOF-MS. All statistical methods confirm that the main effects affecting discolouration were type of iron salt, pH, and temperature. Additionally, several two-way interactions, such as type of iron salt × pH, pH × temperature, and type of iron salt × concentration significantly affected iron-catechol complexation. Our findings provide insight into iron-phenolic complexation-mediated discolouration, and facilitate the design of iron-fortified foods.

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Effect of environmental factors on the complexation of iron and humic acid

Cited by 26 publications

References 43 publications

Phytochelators Intended for Clinical Use in Iron Overload, Other Diseases of Iron Imbalance and Free Radical Pathology

Phytochelators Intended for Clinical Use in Iron Overload, Other Diseases of Iron Imbalance and Free Radical Pathology

Capacity of humic substances to complex with iron at different salinities in the Yangtze River estuary and East China Sea

Revealing the main factors and two-way interactions contributing to food discolouration caused by iron-catechol complexation

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