Effect of engineered superparamagnetic iron oxide nanoparticles in targeted cardiac precursor cell delivery by MRI

Chelluri, Lakshmi Kiran; Mohanram, Yamuna; Jain, Rashi; Mallarpu, Chandra Shekar; Ponnana, Meenakshi; Kumar, Deepak; Venuganti, Venkata Vamsi Krishna; Kancherla, Ravindranath; Papineni, Rao; Towner, Rheal A.; Ghosal, Partha

doi:10.1016/j.bbrc.2021.01.005

Cited by 9 publications

(7 citation statements)

References 24 publications

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“…Literature shows that modification of the SPIONs, as well as the surface modification with various agents to step closer against the most common type of cancer in women-breast cancer [18][19][20]. The application of SPION allows for simultaneous treatment and monitoring of the tumor growth using and magnetic resonance imaging [21][22][23].…”

Section: Introductionmentioning

confidence: 99%

Hybrid System for Local Drug Delivery and Magnetic Hyperthermia Based on SPIONs Loaded with Doxorubicin and Epirubicin

et al. 2021

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Cancer is one of the most common causes of death worldwide, thus new solutions in anticancer therapies are highly sought after. In this work, superparamagnetic iron oxide nanoparticles (SPIONs) conjugated with anticancer drugs are synthesized and investigated as potential magnetic drug nanocarriers for local drug delivery and mild magnetic hyperthermia. We have obtained a hybrid system loaded with holmium and anticancer drugs and thoroughly studied it with respect to the size, morphology, surface modifications and magnetic properties, and interactions with the model of biological membranes, cytotoxicity. We present that nanoparticles having a round shape and size 15 nm are successfully stabilized to avoid their agglomeration and modified with doxorubicin or epirubicin within a controlled way. The number of drugs loaded into the SPIONs was confirmed with thermogravimetry. The hybrid based on SPIONs was investigated in touch with model biological membranes within the Langmuir-Blodgett technique, and results show that modified SPION interacts effectively with them. Results obtained with magnetic hyperthermia and biological studies confirm the promising properties of the hybrid towards future cancer cell treatment.

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Section: Introductionmentioning

confidence: 99%

Hybrid System for Local Drug Delivery and Magnetic Hyperthermia Based on SPIONs Loaded with Doxorubicin and Epirubicin

et al. 2021

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“…Furthermore, the small size of USPIO leads to escape from immediate phagocytosis processes, resulting in an extended half-life of up to 36 h in comparison with 2 h for larger IONPs in humans [ 54 ]. In addition, antibody-conjugated superparamagnetic iron oxide nanoparticles showed a high accumulation in cardiac muscles, and has potentials to be a cardiac precursor label to segregate cells from cardiac/non cardiac origins and traced by MRI [ 55 ].…”

Section: Nanoparticle Types For Intravascular Imagingmentioning

confidence: 99%

Intravascular Imaging of Atherosclerosis by Using Engineered Nanoparticles

Centurion

Chen

et al. 2023

Biosensors

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Atherosclerosis is a leading cause of morbidity and mortality, and high-risk atherosclerotic plaques can result in myocardial infarction, stroke, and/or sudden death. Various imaging and sensing techniques (e.g., ultrasound, optical coherence tomography, fluorescence, photoacoustic) have been developed for scanning inside blood vessels to provide accurate detection of high-risk atherosclerotic plaques. Nanoparticles have been utilized in intravascular imaging to enable targeted detection of high-risk plaques, to enhance image contrast, and in some applications to also provide therapeutic functions of atherosclerosis. In this paper, we review the recent progress on developing nanoparticles for intravascular imaging of atherosclerosis. We discuss the basic nanoparticle design principles, imaging modalities and instrumentations, and common targets for atherosclerosis. The review is concluded and highlighted with discussions on challenges and opportunities for bringing nanoparticles into in vivo (pre)clinical intravascular applications.

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“…The current literature on nanotechnologies in CVDs is focused on paramagnetic iron oxide nanoparticles [106] . This is because of their biocompatibility and diagnostic as well as therapeutic implications in regenerative CV medicine.…”

Section: Main Textmentioning

confidence: 99%