Effect of Endurance Training on Cerebellar Gene Expression of the ADP-Ribosylation Factor 6 in Rats with Diabetic Peripheral Neuropathy

Taherabadi, Seyed Jalal; Rahmati, Masoud; Mirnasuri, Rahim

doi:10.5812/zjrms.84106

Cited by 3 publications

(2 citation statements)

References 27 publications

(27 reference statements)

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“…However, the effects of ET on actin dynamics and its regulatory proteins such as ARF6 and TMOD2 are not clear. In our previous study, we demonstrated that cerebellar ARF6 gene expression was increased in diabetic rats and ET as a non-pharmacologic therapeutic intervention could damp this elevation (18). We concluded that ARF6 is an important mediator of stress-induced plasticity in the nervous system in response to ET and neurodegeneration disease.…”

Section: Introductionmentioning

confidence: 83%

Exercise Training Enhances Expression of Tropomedulin-2 and ADP-Ribosylation Factor 6 in the Cerebellum of Male Wistar Rats

Taherabadi

Rahmati

2019

Zahedan J Res Med Sci

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Background: It has been well documented that exercise training (ET) induces beneficial effects on the central nervous system (CNS); however, the underlying mechanisms are less known. We presumed that actin cytoskeleton regulatory proteins such as ADPribosylation factors 6 (ARF6) and tropomodulin 2 (TMOD2) may be important elements of Exercise-Induced Neuroplasticity (EIN). We evaluated this hypothesis in the present study. Methods: We randomly divided 12 male Wistar rats into control (C) and training (T) groups. The T group was exposed to six weeks of moderate-intensity treadmill running. The ARF6 and TMOD2 gene and protein expressions in the cerebellum of male Wistar rats were assessed by the real-time PCR and western blot analysis. Results: The results showed that TMOD2 and ARF6 gene and protein expressions were significantly higher in the T group than in the C group. Conclusions: It seems that chronic treadmill running increases TMOD2 and ARF6 gene and protein expressions in the cerebellum and these changes probably lead to the improvement of brain function.

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Section: Introductionmentioning

confidence: 83%

Exercise Training Enhances Expression of Tropomedulin-2 and ADP-Ribosylation Factor 6 in the Cerebellum of Male Wistar Rats

Taherabadi

Rahmati

2019

Zahedan J Res Med Sci

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“…In addition, in diabetic conditions, hyperglycemic stress causes oxidative damage to mitochondria, which may lead to apoptosis and cell death (16,17). However, few studies have explained the alteration of cerebellar cellular mechanisms following aerobic exercise (18,19). So far, little is known about the protective effect of endurance exercise on the apoptosis process in the cerebellum of diabetic rats.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Endurance Training on Apoptotic Inducing Factor (AIF) in Cerebellum of Type 1 Diabetic Rats

Taheri¹,

Habibi²,

Shakeryan³

et al. 2020

Ann Appl Sport Sci

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Background. The apoptotic inducing factor (AIF) level increases in the brain of patients with diabetic disease. Objectives. This study aimed to investigate whether endurance training could alleviate apoptosis in the cerebellum of diabetic rats. Methods. Twenty rats were randomly allocated in four groups including 1) healthy control, 2) healthy trained, 3) diabetic, and 4) diabetic trained groups. Diabetes was induced by intraperitoneal injection a single dose of Streptozotocin (45 mg/kg). Training programs on the treadmill were performed at moderate intensity 5 days a week for 6 weeks. The activities apoptotic inducing factor was analyzed in cerebellum of animals at the end of experiment by ELISA method. Results. Our results showed that following six weeks endurance exercise training decreased cytosolic release of apoptotic inducing factor (AIF) in cerebellum of diabetic rats. Conclusion. Our results confirmed that endurance training may be improves brain functions. Understanding mechanisms of exercise on brain functions may lead to the development of novel therapeutic strategy for neurodegenerative disorders such as type 1 diabetes.

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High-intensity interval training increasing ADP-ribosylation factor 6 and Cytochrome C in visceral adipose tissue of male Wistar rats

Rahmati

Shariatzadeh²,

Kazemi

et al. 2019

Obesity Medicine

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Effect of Endurance Training on Cerebellar Gene Expression of the ADP-Ribosylation Factor 6 in Rats with Diabetic Peripheral Neuropathy

Cited by 3 publications

References 27 publications

Exercise Training Enhances Expression of Tropomedulin-2 and ADP-Ribosylation Factor 6 in the Cerebellum of Male Wistar Rats

Exercise Training Enhances Expression of Tropomedulin-2 and ADP-Ribosylation Factor 6 in the Cerebellum of Male Wistar Rats

The Effect of Endurance Training on Apoptotic Inducing Factor (AIF) in Cerebellum of Type 1 Diabetic Rats

High-intensity interval training increasing ADP-ribosylation factor 6 and Cytochrome C in visceral adipose tissue of male Wistar rats

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