Effect of endothelin-1 in man—impact on basal and stimulated concentrations of luteinizing hormone, follicle-stimulating hormone, thyrotropin, growth hormone, corticotropin, and prolactin with and without pretreatment with nifedipine

Vierhapper, H.

doi:10.1016/s0026-0495(96)90039-6

Cited by 12 publications

(8 citation statements)

References 25 publications

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“…This is further supported by the tendency found in our study for higher values of ET in patients with hypogonadotrophic hypogonadism, in whom gonadotrophin concentrations are low. There are several lines of evidence that point to endothelins participating in the regulation of pituitary hormone secretion (Vierhapper et al ., 1993; Vierhapper, 1996; Kiefer et al ., 2000). Release of LH and FSH is stimulated by ET‐3 (Kanyicska et al ., 1991; Furudate et al ., 1994; Naruse et al ., 1994).…”

Section: Discussionmentioning

confidence: 99%

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Increased plasma endothelin levels in patients with male hypogonadism

et al. 2002

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Endothelin has various paracrine and endocrine effects on the male reproductive system. Testosterone is probably responsible for the higher endothelin levels in males. In addition, there is much ambiguity about the relationship between gonadotrophic hormones and endothelin. In order to study in more detail the relationship of endothelin with the hypothalamo-pituitary-gonadal axis in the male, we investigated 18 male patients with various forms of hypogonadism (seven with hypergonadotrophic hypogonadism and 11 with hypogonadotrophic hypogonadism). Eight age-matched healthy males served as controls. The basal endothelin levels in patients with hypogonadism (0.95 +/- 0.53 fmol ml(-1)) were significantly higher than those of the controls (0.54 +/- 0.06 fmol ml(-1); P < 0.05). Males with hypergonadotrophic hypogonadism had significantly increased endothelin concentrations (1.05 +/- 0.57 fmol ml(-1); P < 0.05), whereas those with hypogonadotrophic hypogonadism (0.89 +/- 0.53 fmol ml(-1)) had nonsignificantly (P > 0.05) elevated levels. No significant correlation was found between plasma endothelin levels and gonadotrophin, prolactin and testosterone concentrations. The results of this study suggest that plasma endothelin levels are increased in males with hypogonadism.

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Section: Discussionmentioning

confidence: 99%

“…Like gonadotrophin releasing hormone (GnRH), ET‐1 stimulates, in vitro , luteinizing hormone (LH) and follicle‐stimulating hormone (FSH) production from the pituitary (Stojilkovic et al . 1992; Vierhapper, 1996) and has a modulatory effect on prolactin release (Samson et al ., 1991; Vierhapper, 1996). Hammami et al .…”

Section: Introductionmentioning

confidence: 99%

Increased plasma endothelin levels in patients with male hypogonadism

et al. 2002

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“…It has been reported that ET-1 given i.v. augmented basal and CRH-stimulated ACTH release in normal human subjects (Vierhapper et al 1993), possibly because of increased blood pressure associated with ET-1 infusion, since both the increased ACTH and blood pressure were reversed by the calcium channel antagonist nifedipine (Vierhapper 1996). These data are difficult to interpret, since a cocktail dose of all synthetic hypothalamic releasing hormones was given to each subject, and multiple confounding interactions at the anterior pituitary cannot be discounted.…”

Section: Endothelins (Ets)mentioning

confidence: 99%

Review: Central non-glucocorticoid inhibitors of the hypothalamo-pituitary-adrenal axis

Jessop

1999

Journal of Endocrinology

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“…Another possibility is the involvement of growth hormone (GH), which inhibits ET-1 action in human endothelial cells [44]. However, intravenous ET-1 injection suppresses the growth hormone-releasing hormone (GH-RH)-stimulated increase in GH secretion in healthy man [45]. This suggests the feedback system between the ET-1 system and the GH system.…”

Section: Discussionmentioning

confidence: 99%