2002
DOI: 10.1046/j.1439-0272.2002.00468.x
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Increased plasma endothelin levels in patients with male hypogonadism

Abstract: Endothelin has various paracrine and endocrine effects on the male reproductive system. Testosterone is probably responsible for the higher endothelin levels in males. In addition, there is much ambiguity about the relationship between gonadotrophic hormones and endothelin. In order to study in more detail the relationship of endothelin with the hypothalamo-pituitary-gonadal axis in the male, we investigated 18 male patients with various forms of hypogonadism (seven with hypergonadotrophic hypogonadism and 11 … Show more

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Cited by 10 publications
(8 citation statements)
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References 25 publications
(30 reference statements)
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“…, 2002), we have seen that ET basal levels were increased in the patients in comparison with the healthy men. We did not establish a statistically significant correlation between the plasma levels of ET and gonadotrophins, but suggested a close relationship between testosterone and endothelin levels (Kumanov et al. , 2002).…”
Section: Discussioncontrasting
confidence: 68%
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“…, 2002), we have seen that ET basal levels were increased in the patients in comparison with the healthy men. We did not establish a statistically significant correlation between the plasma levels of ET and gonadotrophins, but suggested a close relationship between testosterone and endothelin levels (Kumanov et al. , 2002).…”
Section: Discussioncontrasting
confidence: 68%
“…In our previous study in hypogonadal men (Kumanov et al, 2002), we have seen that ET basal levels were increased in the patients in comparison with the healthy men. We did not establish a statistically significant correlation between the plasma levels of ET and gonadotrophins, but suggested a close relationship between testosterone and endothelin levels (Kumanov et al, 2002). Therefore, as a second step in our investigation, we followed up the ET-1 levels before and after testosterone medication.…”
Section: Discussionmentioning
confidence: 67%
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“…However, several possible mechanisms have been suggested to explain the antihypertensive effects of testosterone. Kumanov established that plasma endothelin 1 (ET1) levels are elevated in males with hypogonadism, and testosterone treatment decreases ET1 [62, 63]. Another hypothesis is that testosterone treatment of hypogonadism normalizes the contractile RhoA/Rho-kinase (ROCK) signaling pathway, which is upregulated in hypogonadal states [64].…”
Section: Hypogonadism and Atherosclerotic Risk Factorsmentioning
confidence: 99%