Effect of Endemic Fluorosis on Hematological Parameters

Ersoy, Ismail Hakki; Alanoğlu, Emine Güçhan; Köroğlu, Banu Kale; Varol, Simge; Akcay, Selahaddin; Ugan, Yunus; Ersoy, Siddika; Tamer, Mehmet Numan

doi:10.1007/s12011-009-8595-3

Cited by 13 publications

(5 citation statements)

References 10 publications

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“…Fluorine is one of the essential trace elements for human health [ 1 ]. However, excessive fluoride intake can cause serious tissue damage and lead to multiple organ dis-function [ 2 , 3 ], which depends not only on the concentration and exposed duration [ 4 , 5 ], but also on the absorption capacity, age, and nutritional status of the individual [ 6 ]. It has been demonstrated that fluoride can induce skeletal fluorosis and soft tissue damage [ 7 - 9 ].…”

Section: Introductionmentioning

confidence: 99%

Sodium fluoride induces apoptosis in cultured splenic lymphocytes from mice

et al. 2016

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Though fluorine has been shown to induce apoptosis in immune organs in vivo, there has no report on fluoride-induced apoptosis in the cultured lymphocytes. Therefore, this study was conducted with objective of investigating apoptosis induced by sodium fluoride (NaF) and the mechanism behind that in the cultured splenic lymphocytes by flow cytometry, western blot and Hoechst 33258 staining. The splenic lymphocytes were isolated from 3 weeks old male ICR mice and exposed to NaF (0, 100, 200, and 400 μmol/L) in vitro for 24 and 48 h. When compared to control group, flow cytometry assay and Hoechst 33258 staining showed that NaF induced lymphocytes apoptosis, which was promoted by decrease of mitochondria transmembrane potential, up-regulation of Bax, Bak, Fas, FasL, caspase 9, caspase 8, caspase 7, caspase 6 and caspase 3 protein expression (P < 0.05 or P <0.01), and down-regulation of Bcl-2 and Bcl-xL protein expression (P <0.05 or P <0.01). The above-mentioned data suggested that NaF-induced apoptosis in splenic lymphocytes could be mediated by mitochondrial and death receptor pathways.

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Section: Introductionmentioning

confidence: 99%

Sodium fluoride induces apoptosis in cultured splenic lymphocytes from mice

et al. 2016

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“…However, it has been reported that changes due to fluoride exposure occur earlier in blood compared to other tissues and organs [8]. Previous studies revealed that fluoride had unfavorable effects on hematological and biochemical parameters [9, 10] in rats [11, 12], mice [13–15], sheep [16], rabbits [17, 18], dogs [19], camels [20], and humans [8, 21]. …”

Section: Introductionmentioning

confidence: 99%

Effect of Resveratrol on Hematological and Biochemical Alterations in Rats Exposed to Fluoride

Atmaca

Yıldırım

Güner

et al. 2014

BioMed Research International

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We investigated the protective effects of resveratrol on hematological and biochemical changes induced by fluoride in rats. A total of 28 rats were divided into 4 groups: control, resveratrol, fluoride, and fluoride/resveratrol (n = 7 each), for a total of 21 days of treatment. Blood samples were taken and hematological and biochemical parameters were measured. Compared to the control group, the fluoride-treated group showed significant differences in several hematological parameters, including decreases in WBC, RBC, and PLT counts and neutrophil ratio. The group that received resveratrol alone showed a decrease in WBC count compared to the control group. Furthermore, in comparison to the control group, the fluoride group showed significantly increased ALT enzyme activity and decreased inorganic phosphorus level. The hematological and biochemical parameters in the fluoride + resveratrol treated group were similar to control group. In the fluoride + resveratrol group, resveratrol restored the changes observed following fluoride treatment, including decreased counts of WBC, RBC, and PLT, decreased neutrophil ratio and inorganic phosphorus levels, and elevated ALT enzyme activity. The present study showed that fluoride caused adverse effects in rats and that resveratrol reduced hematological and biochemical alterations produced by fluoride exposure.

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“…However, Khandare et al 54 reported no adverse effects of fluorine on hematological variables in dogs. Likewise, Ersoy et al 55 did not observe effects on any hematological variables in humans with endemic fluorosis. Few studies have reported on the effects of dietary krill meal on blood indices.…”

Section: Blood Characteristicsmentioning

confidence: 89%

Antarctic krill meal as an alternative protein source in pet foods evaluated in mink (Neovison vison). II. Growth

Krogdahl¹,

Ahlstrøm²,

Burri³

et al. 2015

OAAP

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Background: Antarctic krill meal has potential for use in pet food as a source of protein and lipids. An experiment was conducted in growing male and female mink to evaluate the safety of Antarctic krill meal as an ingredient for pet food. Materials and methods: In the first growth period, the levels of krill were 0%, 8%, 17%, and 33% of dry matter. The levels were slightly less in the second growth period (0%, 8%, 16%, and 32% of dry matter). The four diets used were labeled K0, K8, K17, and K33 for both growth periods. The experiments included assessments of growth, hematology, clinical chemistry, tissue histology, liver and kidney mineral concentrations, and bone fluoride accumulation. Results: Mink receiving Antarctic krill meal grew at the same rate as controls, suggesting that protein and energy values of the krill meal were comparable to the control fishmeal. Relative organ weights of animals were the same for the K0, K8, and K17 groups, whereas K33 animals showed higher values for weights of the stomach and rectum. Hematological, clinical chemistry, and morphological analyses did not differ between animals fed K0 and K8 diets. Animals in the K17 and K33 groups showed some histological changes in the liver and kidney, and a few alterations in some clinical chemistry and hematology values related to nutrient intake or metabolism. Joint/bone deformities were observed in K33 mink. Conclusion: Antarctic krill meal has a similar nutritional value as good-quality fishmeal and produces no adverse effects in growing mink at levels up to 8% of dry matter. The results suggest that Antarctic krill meal can be safely included in pet food for growing animals.

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Effect of Endemic Fluorosis on Hematological Parameters

Cited by 13 publications

References 10 publications

Sodium fluoride induces apoptosis in cultured splenic lymphocytes from mice

Sodium fluoride induces apoptosis in cultured splenic lymphocytes from mice

Effect of Resveratrol on Hematological and Biochemical Alterations in Rats Exposed to Fluoride

Antarctic krill meal as an alternative protein source in pet foods evaluated in mink (Neovison vison). II. Growth

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