Effect of Elk Velvet Antler Supplementation on the Hormonal Response to Acute and Chronic Exercise in Male and Female Rowers

Syrotuik, Daniel G.; MacFadyen, Kirsten L; Harber, Vicki J.; Bell, Gordon J.

doi:10.1123/ijsnem.15.4.366

Cited by 11 publications

(10 citation statements)

References 20 publications

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“…In earlier studies, elk velvet antler has been noted for several biological activities (Allen et al 2002;Hemmings and Song 2004;Mikler et al 2004;Moreau et al 2004;Syrotuik et al 2005). However, until this study, there has been little information on the free-radical scavenging activity of antler extracts.…”

Section: Introductionmentioning

confidence: 80%

“…The radical scavenging activity of enzymatic extracts of elk velvet antler differs from section to section based on the kinds of enzymes and their doses. In the research, elk velvet antler has been noted for several biological activities (Allen et al 2002;Hemmings and Song 2004;Mikler et al 2004;Moreau et al 2004;Syrotuik et al 2005). However, to date, there were no studies of free-radical scavenging activity by using ESR spectroscopy and protective effects of neuronal cells of enzymatic extracts from elk velvet antler.…”

Section: Neuroprotective Effect Against H 2 Omentioning

confidence: 99%

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Free Radical Scavenging Activity by Esr Spectroscopy and Neuroprotective Effect on H2o2-Induced Damage in Pc-12 Cells of Enzymatic Extracts From Korean Elk Velvet Antler

Kim¹,

Lee²,

Moon³

et al. 2009

Journal of Food Biochemistry

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The free‐radical scavenging activity and the neuroprotective effect of Korean elk velvet antler were assessed using an electron spin resonance spectrometer and a flow cytometer. Elk velvet antler was divided into three sections. The antler was then hydrolyzed by four proteases. All enzymatic extracts from the elk velvet antler effectively reduced the intensities of four kinds of free radicals. Papain extract from the upper section showed the highest scavenging activity on 1,1‐diphenyl‐2‐picrylhydrazyl and hydroxyl radicals; the IC50 values were 1.70 and 0.16 mg/mL, respectively. ά‐chymotrypsin extract from the middle section showed the highest scavenging activity on alkyl and superoxide radicals; the IC50 values were 0.84 and 1.73 mg/mL, respectively. Additionally, papain extract from the upper section (1.0 mg/mL) decreased cell death in PC‐12 cells caused by H2O2‐induced oxidative damage. These results indicate that enzymatic extracts from Korean elk velvet antler show antioxidative activity by means of scavenging free radicals and decreasing cell death caused by H2O2‐induced oxidative damage. PRACTICAL APPLICATIONS Elk velvet antler has long been used as a traditional medicine for relieving pain, aging and inflammation in Korea and China. In general, it is preparated by the method of hot water extract as liquefied products. In the present study, many industrial commercial enzymes such as α‐chymotrypsin, pepsin, papain and trypsin were used to produce a number of effective extracts. In addition, the enzymatic extracts from Korea elk velvet antler have shown antioxidative activity. Therefore, they have the potential to be developed into new health foods.

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Section: Introductionmentioning

confidence: 80%

Section: Neuroprotective Effect Against H 2 Omentioning

confidence: 99%

Free Radical Scavenging Activity by Esr Spectroscopy and Neuroprotective Effect on H2o2-Induced Damage in Pc-12 Cells of Enzymatic Extracts From Korean Elk Velvet Antler

Kim¹,

Lee²,

Moon³

et al. 2009

Journal of Food Biochemistry

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“…One recent review reported that aqueous extract of deer antler base prolonged the endurance exercise time in untrained test animals [1]. However, a previous report showed that 10 weeks of elk velvet antler supplementation combined with training did not improve the rowing performance of male and female rowers [17]. Based on these results, we suggest that CCP, ethanolic extract of deer antler, improves body strength but not endurance performance in the absence of training.…”

Section: Resultsmentioning

confidence: 61%

Cornu Cervi Pantotrichum Supplementation Improves Exercise Performance and Protects against Physical Fatigue in Mice

et al. 2014

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Abstract:Cornu cervi pantotrichum (CCP) is a well-known yang-invigorating agent used in traditional Chinese medicine that can nourish the blood, tonify qi, and invigorate bones and tendons with multifunctional bioactivities. However, evidence on the effects of CCP on exercise performance and physical fatigue is limited. We evaluated the potential beneficial effects of ethanolic extract from CCP on ergogenic and antifatigue functions following a physiological challenge. Male ICR mice from four groups (n = 8 per group) were orally administered CCP for 14 days at 0, 2054, and 4108 mg/kg/day, and were respectively designated as the vehicle, CCP-1X, and CCP-2X groups. The physical performance and antifatigue function were evaluated using forelimb grip strength and exhaustive swimming time as well as serum levels of lactate, ammonia, glucose, and creatine kinase after a 15-min swimming exercise. The results indicated that CCP-1X supplementation significantly improved grip strength; reduced fatigue-associated biochemical indices, including lactate and ammonia levels; and ameliorated skeletal muscle injury induced by acute exercise challenge. A trend analysis revealed that CCP supplementation significantly increased grip strength and dose-dependently reduced serum OPEN ACCESSMolecules 2014, 19 4670 alkaline phosphatase, uric acid, triacylglycerol, and glucose levels in healthy mice. Therefore, CCP is a potential agent with an antifatigue pharmacological effect.

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“…Evidence has shown that the performance (strength and endurance) could be significantly improved [15, 26] via the possible regulation of troponin mRNA expression in skeletal muscle [4]. However, a contradictory report shows that CCP supplementation combined with 10 weeks of training did not significantly improve rowing performance in rowers [27]. In the current study, we also found that CCP supplementation combined with training (ET+CCP group) did not significantly elevate performance when compared to the group that received ET treatment only (Figs.…”

Section: Discussionmentioning

confidence: 99%

<i>Cornu cervi pantotrichum</i> supplementation improves physiological adaptions during intensive endurance training

Huang

Chuang

et al. 2017

The Journal of Veterinary Medical Science

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Cornu cervi pantotrichum (CCP), used in traditional Chinese medicine, is a well-known yang-invigorating agent with multifunctional bioactivities. We previously showed, through an acute exercise challenge, that short-term CCP supplementation improved physical activities and fatigue-associated biochemical indices. Questions about the long-term effects of CCP treatment on exercise performance and physical fatigue, as well as safety, with intensive exercise training need further research. ICR-strain mice were randomly assigned to three groups: (1) sedentary control and vehicle treatment (SC); (2) exercise training with vehicle treatment (ET); and (3) ET with CCP treatment at 4,108 mg/kg/day (ET+CCP). We assessed the physical performance, body compositions, and serum levels of lactate, ammonia, glucose and creatine kinase (CK) after an acute exercise challenge. The ET and ET+CCP groups had significantly increased grip strength and endurance swimming time, and decreased serum lactate and ammonia levels after the acute exercise challenge than the SC group. Moreover, serum ammonia and CK levels in the ET+CCP group were significantly decreased when compared to that of the ET only group. In regard to the body composition, the ET+CCP group inhibits the decrease in fat tissue, and related biochemical changes induced by the high intensity endurance training CCP supplementation combined with high-intensity endurance exercise could significantly improve the physiological adaptions related to fatigue or energy consumption and maintain the fat composition when compared to treatment with training only. Therefore, CCP may potentially improve the physiological adaptions in intensive exercise training.

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Effect of Elk Velvet Antler Supplementation on the Hormonal Response to Acute and Chronic Exercise in Male and Female Rowers

Cited by 11 publications

References 20 publications

Free Radical Scavenging Activity by Esr Spectroscopy and Neuroprotective Effect on H2o2-Induced Damage in Pc-12 Cells of Enzymatic Extracts From Korean Elk Velvet Antler

Free Radical Scavenging Activity by Esr Spectroscopy and Neuroprotective Effect on H2o2-Induced Damage in Pc-12 Cells of Enzymatic Extracts From Korean Elk Velvet Antler

Cornu Cervi Pantotrichum Supplementation Improves Exercise Performance and Protects against Physical Fatigue in Mice

<i>Cornu cervi pantotrichum</i> supplementation improves physiological adaptions during intensive endurance training

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