Cornu Cervi Pantotrichum Supplementation Improves Exercise Performance and Protects against Physical Fatigue in Mice

Huang, Chi‐Chang; Kan, Nai Wen; Chao, Hui; Ho, Chen Hsun; Hsu, Mei‐Chich

doi:10.3390/molecules19044669

Cited by 19 publications

(11 citation statements)

References 24 publications

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“…Thus, long-term FCD supplementation can benefit grip strength when no training protocol is implemented. Our previous reports have shown that seven to twenty-one days of supplementation with plant extracts, resveratrol, ethanolic extract of deer antler, or long-term supplementation with ergogenic aids, such as whey protein, improves the grip strength of untrained animals [ 17 , 20 , 21 , 22 ]. Thus, FCD, a substance of brown algae origin used as an ingredient in some health food, may be an alternative supplement for promoting body strength under an untrained condition or in a programmed-training protocol.…”

Section: Resultsmentioning

confidence: 99%

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Fucoidan Supplementation Improves Exercise Performance and Exhibits Anti-Fatigue Action in Mice

Chen

Tsai

et al. 2014

Nutrients

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Fucoidan (FCD) is a well-known bioactive constituent of seaweed extract that possess a wide spectrum of activities in biological systems, including anti-cancer, anti-inflammation and modulation of immune systems. However, evidence on the effects of FCD on exercise performance and physical fatigue is limited. Therefore, we investigated the potential beneficial effects of FCD on ergogenic and anti-fatigue functions following physiological challenge. Male ICR mice from three groups (n = 8 per group) were orally administered FCD for 21 days at 0, 310 and 620 mg/kg/day, which were, respectively, designated the vehicle, FCD-1X and FCD-2X groups. The results indicated that the FCD supplementations increased the grip strength (p = 0.0002) and endurance swimming time (p = 0.0195) in a dose-depend manner. FCD treatments also produced dose-dependent decreases in serum levels of lactate (p < 0.0001) and ammonia (p = 0.0025), and also an increase in glucose level (p < 0.0001) after the 15-min swimming test. In addition, FCD supplementation had few subchronic toxic effects. Therefore, we suggest that long-term supplementation with FCD can have a wide spectrum of bioactivities on health promotion, performance improvement and anti-fatigue.

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Section: Resultsmentioning

confidence: 99%

“…Effects of FCD supplementation on fatigue-associated biochemical indices were evaluated post-exercise as our previous reports [ 15 , 17 , 20 , 22 ]. At 1 h after the FCD supplementation, all animals underwent a 15-min swim test without weight loading.…”

Section: Methodsmentioning

confidence: 99%

Fucoidan Supplementation Improves Exercise Performance and Exhibits Anti-Fatigue Action in Mice

Chen

Tsai

et al. 2014

Nutrients

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“…The effect of LP10 supplementation on fatigue-associated biochemical indices was evaluated after exercise as previously described [ 28 , 29 ]. At 1 h after LP10 supplementation, all mice underwent a 15-min swim test without weight loading.…”

Section: Methodsmentioning

confidence: 99%

Lactobacillus plantarum TWK10 Supplementation Improves Exercise Performance and Increases Muscle Mass in Mice

et al. 2016

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Lactobacillus plantarum (L. plantarum) is a well-known probiotic among the ingested-microorganism probiotics (i.e., ingested microorganisms associated with beneficial effects for the host). However, few studies have examined the effects of L. plantarum TWK10 (LP10) supplementation on exercise performance, physical fatigue, and gut microbial profile. Male Institute of Cancer Research (ICR) strain mice were divided into three groups (n = 8 per group) for oral administration of LP10 for six weeks at 0, 2.05 × 108, or 1.03 × 109 colony-forming units/kg/day, designated the vehicle, LP10-1X and LP10-5X groups, respectively. LP10 significantly decreased final body weight and increased relative muscle weight (%). LP10 supplementation dose-dependently increased grip strength (p < 0.0001) and endurance swimming time (p < 0.001) and decreased levels of serum lactate (p < 0.0001), ammonia (p < 0.0001), creatine kinase (p = 0.0118), and glucose (p = 0.0151) after acute exercise challenge. The number of type I fibers (slow muscle) in gastrocnemius muscle significantly increased with LP10 treatment. In addition, serum levels of albumin, blood urea nitrogen, creatinine, and triacylglycerol significantly decreased with LP10 treatment. Long-term supplementation with LP10 may increase muscle mass, enhance energy harvesting, and have health-promotion, performance-improvement, and anti-fatigue effects.

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“…Fermentation with Lactobacillus sp. has been reported to enhance absorption of bioactive molecules, and aid in immune modulation, cholesterol homeostasis, exercise performance [ 13 – 16 ]. The purpose of the present study was to enhance the concentration of bioactive ingredients (e.g., sialic acid and gamma-aminobutyric acid [GABA]) in fermented antler velvet (FAV) and evaluate its effects on immune response in Caenorhabditis elegans and mouse models.…”

Section: Introductionmentioning

confidence: 99%

Enhanced γ-aminobutyric acid and sialic acid in fermented deer antler velvet and immune promoting effects

Yoo¹,

Lee²,

Zou³

et al. 2022

J Anim Sci Technol

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Deer antler velvet is widely used in traditional medicine for its anti-aging, antioxidant, and immunity-enhancing effects. However, few studies have reported on the discovery of probiotic strains for deer antler fermentation to increase functional ingredient absorption. This study evaluated the ability of probiotic lactic acid bacteria to enhance the concentrations of bioactive molecules (e.g., sialic acid and gamma-aminobutyric acid [GABA]) in extracts of deer antler velvet. Seventeen strains of Lactobacillus spp. that were isolated from kimchi and infant feces, including L. sakei , L. rhamnosus , L. brevis , and L. plantarum , and those that improved the life span of Caenorhabditis elegans were selected for evaluation. Of the 17 strains, 2 ( L. rhamnosus LFR20-004 and L. sakei LFR20-007) were selected based on data showing that these strains increased both the sialic acid and GABA contents of deer antler extract after fermentation for 2 d and significantly improved the life span of C. elegans . Co-fermentation with both strains further increased the concentrations of sialic acid, GABA, and metabolites such as short-chain fatty acids and amino acids. We evaluated the biological effects of the fermented antler velvet (FAV) on the antibacterial immune response in C. elegans by assessing worm survival after pathogen infection. The survival of the C. elegans conditioned with FAV for 24 h was significantly higher compared with that of the control worm group fed only normal feed (non-pathogenic E. coli OP50) exposed to E. coli O157:H7, Salmonella typhi , and Listeria monocytogenes . To evaluate the protective effects of FAV on immune response, cyclophosphamide (Cy), an immune-suppressing agent was treated to in vitro and in vivo . We found that FAV significantly restored viability of mice splenocytes and immune promoting-related cytokines (interleukin [IL]-6, IL-10, inducible nitric oxide synthase [iNOS], interferon [IFN]-γ, and tumor necrosis factor [TNF]-α) were activated compared to non-fermented deer antlers. This finding indicated the protective effect of FAV against Cy-induced cell death and immunosuppressed mice. Taken together, our study suggests that immune-promoting antler velvet can be produced through fermentation using L. rhamnosus LFR20-004 and L. sakei LFR20-007.

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Cornu Cervi Pantotrichum Supplementation Improves Exercise Performance and Protects against Physical Fatigue in Mice

Cited by 19 publications

References 24 publications

Fucoidan Supplementation Improves Exercise Performance and Exhibits Anti-Fatigue Action in Mice

Fucoidan Supplementation Improves Exercise Performance and Exhibits Anti-Fatigue Action in Mice

Lactobacillus plantarum TWK10 Supplementation Improves Exercise Performance and Increases Muscle Mass in Mice

Enhanced γ-aminobutyric acid and sialic acid in fermented deer antler velvet and immune promoting effects

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