Effect of elevated temperature and of hypoxia on NO activity in the central nervous system of bivalve molluscs

Kotsyuba, E. P.

doi:10.1134/s0022093008020126

Cited by 5 publications

(8 citation statements)

References 11 publications

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“…Our ultrastructural observations of NADPH-d localization in the neurons of C. grayanus are in agreement with the results of studies of nitroxidergic systems in the CNS of mammals (Wolf et al 1992;Tseng et al 2000; López- Costa et al 2002), fish (Ruzhinskaya and Gdovskii 2002), and several species of bivalve mollusks (Kotsyuba and Kotsyuba 2003;Kotsyuba 2008).…”

Section: Discussionsupporting

confidence: 91%

“…No NADPH-d-positive neurons were revealed in control sections. Localization of NADPH-d-positive neuron bodies and processes in the Gray mussel pedal ganglia generally corresponded to previous findings (Kotsyuba 2008). Within the cortex, NADPH-d reactivity was mainly localized in the perikarya of neurons located in the anterior and posterior-dorsomedial part of the ganglia.…”

Section: Resultssupporting

confidence: 79%

“…Only scattered formazan granules were found in these organelles. The type II cytosomes (0.2-2.0 lm in diameter) are not detected by routine TEM but become clearly visible after NADPH-d staining, and their number and staining intensity greatly increase under stress conditions (hypoxia, hyperthermia) (Kotsyuba and Kotsyuba 2003;Kotsyuba 2008). The type III cytosomes are represented by autophagosomes containing the remnants of various cellular organelles, mainly mitochondria and NADPH-d stained cytosomes; therefore, autophagosomes can also contain formazan deposits.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, the histochemical NADPH-d reaction has been taken as indicative for the presence of NOS, and positive NADPH-d staining has been widely used as a marker for putative NOS activity in the CNS of both vertebrates (Hope et al 1991;Blottner et al 1995;Huynh and Boyd 2007) and invertebrates, including mollusks (Moroz 2000;Annikova et al 2000;Newcomb and Watson 2001). Besides, NADPH-d reaction has been successfully performed in electron microscopy studies of ultrastructural localization of NADPH-d in the CNS of both mammals (Wolf et al 1992;Tseng et al 2000) and bivalve mollusks (Kotsyuba and Kotsyuba 2003;Kotsyuba 2008).…”

Section: Introductionmentioning

confidence: 98%

“…During the last decades, an increasing number of reports have evidenced that nitric oxide (NO), a phylogenetically ancient signaling molecule, is involved in the responses to environmental stress in both vertebrates and invertebrates. Thus, several studies suggest participation of NO-signaling in stress reactions in sponges exposed to heat stress (Giovine et al 2001), lobsters subject to pesticide pollution (Casares and Mantione 2006), and bivalve mollusks exposed to tributyltinoxide (Smith et al 2000), hypoxia and high temperature (Kotsyuba and Kotsyuba 2003;Kotsyuba 2008), and environmental pollution (Gonzalez et al 2008;Vaschenko and Kotsyuba 2008).…”

Section: Introductionmentioning

confidence: 98%

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Neuroplastic and neuropathological changes in the central nervous system of the Gray mussel Crenomytilus grayanus (Dunker) under environmental stress

Kotsyuba

Vaschenko

2010

Invert Neurosci

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We studied here neuron ultrastructure, synaptic plasticity and subcellular localization of NADPH-diaphorase (NADPH-d), a cytochemical marker for nitric oxide syntase, in the pedal ganglia of the Gray mussel Crenomytilus grayanus sampled from the polluted and reference sites in Amursky Bay (Sea of Japan) at lower and higher water temperature (in the beginning and the end of August, respectively). At lower temperature, neuroplastic changes in mussel ganglia prevailed: a sharp increase in the number of cytosomes in NADPH-d-positive neurons and a sharp decrease in the number of mitochondria in both NADPH-d-positive and NADPH-d-negative neurons. At higher temperature, neurodegenerative changes prevailed: disruption of a part of NADPH-d-negative axons and interneuronal contacts, formation of concentric lamellar structures in the neuropils, and accumulation of autophagosomes in NADPH-d negative neurons. The results suggest that the stress-induced production of nitric oxide in cytosomes of mussel neurons and plasticity of gap junctions have a neuroprotective effect.

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Section: Discussionsupporting

confidence: 91%

Section: Resultssupporting

confidence: 79%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 98%

See 3 more Smart Citations

Neuroplastic and neuropathological changes in the central nervous system of the Gray mussel Crenomytilus grayanus (Dunker) under environmental stress

Kotsyuba

Vaschenko

2010

Invert Neurosci

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Hypoxia-inducible factor 1α in the central nervous system of the scallop Mizuhopecten yessoensis Jay, 1857 (Bivalvia: Pectinidae) during anoxia and elevated temperatures

Kotsyuba

2017

Russ J Mar Biol

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Comparative Neuroanatomy of Pediveliger Larvae of Various Bivalves from the Sea of Japan

Nikishchenko,

Kolotukhina,

Dyachuk

2023

Biology

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Here, we describe the nervous system structures from pediveligers of eight bivalve species (Callista brevisiphonata, Mactromeris polynyma, Crenomytilus grayanus, Kellia japonica, Mizuhopecten yessoensis, and Azumapecten farreri) with different modes of life in their adult stages, corresponding to the ecological niches that they occupy (burrowing, cemented, byssally attached, and mobile forms). We have identified neuromorphological features of the central and peripheral nervous systems in larval bivalves. We show that the unpaired sensory apical organ is still present in pediveligers along with the developing paired cerebral ganglia characteristic of an adult mollusk. Pediveligers have the pleural ganglia connected to the pedal ganglia via the pedal nerve cords and to the visceral ganglia via the lateral nerve cords. We have found a number of structures of the peripheral nervous system whose presence varies between pediveligers of different species. Mactromeris, Callista, and Pododesmus have 5-HT-immunopositive stomatogastric neurons, whereas the Yesso and Farrer’s scallops have an FMRFamide-immunopositive enteric nervous system. The innervation of the anterior part of the velum is connected to a system of the apical organ and cerebral ganglia, and the innervation of the posterior part is connected to the visceral ganglia. Most differences in the structure of the peripheral elements of the nervous system are species-specific and weakly depend on the ecological niche that pediveligers occupy.

show abstract

Effect of elevated temperature and of hypoxia on NO activity in the central nervous system of bivalve molluscs

Cited by 5 publications

References 11 publications

Neuroplastic and neuropathological changes in the central nervous system of the Gray mussel Crenomytilus grayanus (Dunker) under environmental stress

Neuroplastic and neuropathological changes in the central nervous system of the Gray mussel Crenomytilus grayanus (Dunker) under environmental stress

Hypoxia-inducible factor 1α in the central nervous system of the scallop Mizuhopecten yessoensis Jay, 1857 (Bivalvia: Pectinidae) during anoxia and elevated temperatures

Comparative Neuroanatomy of Pediveliger Larvae of Various Bivalves from the Sea of Japan

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