Effect of elemental nano-selenium on semen quality, glutathione peroxidase activity, and testis ultrastructure in male Boer goats

Shi, Liguang; Yang, Rujie; Yue, Wenbin; Xun, Wenjuan; Zhang, Chunxiang; Ren, Youshe; Shi, Lei; Lei, Fulin

doi:10.1016/j.anireprosci.2009.10.003

Cited by 111 publications

(77 citation statements)

References 39 publications

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“…An interesting study [13] showed that selenium deficiency is associated with significant decrease in the activity of GPx. In line with our results, Shi et al [15] and Hao et al [28] reported that the activities of GPx and SOD significantly increased in the tissues of groups fed selenium, and the lowest MDA level was observed in selenium supplemented group. Rats in stressed group had lower and those received nSe had higher the level of reduced glutathione.…”

Section: Discussionsupporting

confidence: 80%

“…It was demonstrated [11,[14][15][16]37] that selenium is an essential factor for normal testis function and spermatogenesis. Selenium can reduce free radicals as a cofactor for antioxidant enzymes such as GPx and through this function can increase the sperm quality and quantity parameters and finally its fertility.…”

Section: Discussionmentioning

confidence: 99%

“…Selenium deficiency causes a decrease in intracellular glutathione peroxidase (GPx) activity [13], sperm parameters [14,15] and decrease in plasma thyroid hormones levels [12]. In the previous studies [16][17][18], the effects of organic and inorganic sources of selenium on the immunity, growth, health, and reproduction in human and animals were examined; however, effect of nano-particles of selenium on mentioned parameters remained unknown.…”

Section: Introductionmentioning

confidence: 99%

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Plasma antioxidant capacity, sexual and thyroid hormones levels, sperm quantity and quality parameters in stressed male rats received nano-particle of selenium

Rezaeian-Tabrizi

Sadeghi

2017

APJR

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Section: Discussionsupporting

confidence: 80%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Plasma antioxidant capacity, sexual and thyroid hormones levels, sperm quantity and quality parameters in stressed male rats received nano-particle of selenium

Rezaeian-Tabrizi

Sadeghi

2017

APJR

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“…Not all NPs will necessarily demonstrate an adverse effect leading to toxicity. For example, some NPs show a beneficial or nontoxic effect on spermatogenesis [9,10]. It has been reported that nanoselenium diet supplementation produced positive effects on sperm quality in male goats [9].…”

Section: Introductionmentioning

confidence: 99%

The effect of zinc oxide nanoparticles on mouse spermatogenesis

Talebi

Khorsandi

Moridian³

2013

J Assist Reprod Genet

126

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Objective To evaluate the effects of zinc oxide nanoparticles on mouse spermatogenesis. Methods Thirty two adult male NMRI mice were used. Experimental Groups (ZNP-1-ZNP-3) received one of the following treatments daily for 35 days: 5, 50 and 300 mg/kg zinc oxide nanoparticles respectively. Control group received only distilled water. Epididymal sperm parameters, testicular histopathology, morphometric analysis and spermatogenesis assessments were performed for evaluation of the zinc oxide nanoparticles effects on testis. Results Epididymal sperm parameters including sperm number, motility and percentage of abnormality were significantly changed in 50 and 300 mg/kg zinc oxide nanoparticles treated mice (p<0.01). Histopathological criteria such as epithelial vacuolization, sloughing of germ and detachment were significantly increased in 50 and 300 mg/kg zinc oxide nanoparticles treated mice (p<0.001). 300 mg/kg zinc oxide nanoparticles induced formation of multinucleated giant cells in the germinal epithelium. 50 and 300 mg/kg zinc oxide nanoparticles also caused a significant decrease in seminiferous tubule diameter, seminiferous epithelium height and maturation arrest (p<0.001). Conclusion Zinc oxide nanoparticles act as testicular toxicant and further studies are needed to establish its mechanism of action upon spermatogenesis.

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“…Spermatozoa have an unusual lipid composition of plasma membranes distinct from those of mammalian somatic cells. They are rich in polyunsaturated fatty acids and are very susceptible to be attacked by ROS [19,20]. ROS can modify different biomolecules including the polyunsaturated fatty acids of sperm membranes resulting in a lipid peroxidation (LPO).…”

Section: Introductionmentioning

confidence: 99%

Glutathione antioxidant protection system in ejaculated spermatozoa of infertile men with different forms of pathospermia

Фафула¹,

Onufrovych²,

Vorobets³

et al. 2017

Biol. Stud.

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The level of the products of lipid peroxidation measured as the thiobarbituric acid reactive substances (TBARS) and activity of enzymes of glutathione antioxidant protection system in spermatozoa were studied. It was shown that mean levels of TBARS in sperm cells of infertile men with oligozoo-, astenozoo-, oligoastenozoo-and leucocytospermia were 1.6-, 2.0-, 2.0-and 2.7-fold higher, respectively, compared with such levels in the fertile men. The glutathione peroxidase activity was decreased 2.2-fold in patients with oligozoospermia, 2.8-fold in patients with astenozoo-and oligoastenozoospermia and 3.8-fold in patients with leucocytospermia. It was found that glutathione reductase activity in patients with oligozoo-, astenozoo-, oligoastenozoo-and leucocytospermia were 2.3-, 1.6-, 1.7-and 3.3-fold lower than that in normozoospermic men, respectively. In addition, the glutathione transferase activity was decreased 1.8-2.1-fold in patients with oligozoo-, astenozoo-and oligoastenozoospermia and 5.0-fold in patients with leuco cytospermia in comparison with healthy donors. The most significant changes were observed in the infertile men with leucocytospermia. This manifestation could be explained by the fact that white blood cells stimulate the formation of reactive oxygen species, induction and development of oxidative stress in sperm cells.

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Effect of elemental nano-selenium on semen quality, glutathione peroxidase activity, and testis ultrastructure in male Boer goats

Cited by 111 publications

References 39 publications

Plasma antioxidant capacity, sexual and thyroid hormones levels, sperm quantity and quality parameters in stressed male rats received nano-particle of selenium

Plasma antioxidant capacity, sexual and thyroid hormones levels, sperm quantity and quality parameters in stressed male rats received nano-particle of selenium

The effect of zinc oxide nanoparticles on mouse spermatogenesis

Glutathione antioxidant protection system in ejaculated spermatozoa of infertile men with different forms of pathospermia

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