Effect of electron beam irradiation sterilization on biomedical polylactic acid composite filled with Scomberomorus Guttatus-derived hydroxyapatite

Ng, Hon-Meng; Bee, Soo‐Tueen; Sin, Lee Tin; Ratnam, Chantara Thevy; Rahmat, Abdul Razak

doi:10.1016/j.compositesb.2019.107273

Cited by 13 publications

(8 citation statements)

References 64 publications

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“…The exposure of materials to gamma radiation or electron beams in the 10-50 kGy dose range is an accepted method worldwide for sterilization purposes [22,23]. However, compared to gamma radiation, due to their low penetration, the electron beams are used mainly for the sterilization of surfaces.…”

Section: Introductionmentioning

confidence: 99%

The Effects of Electron Beam Irradiation on the Morphological and Physicochemical Properties of Magnesium-Doped Hydroxyapatite/Chitosan Composite Coatings

et al. 2022

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This work reports on the influence of 5 MeV electron beam radiations on the morphological features and chemical structure of magnesium-doped hydroxyapatite/chitosan composite coatings generated by the magnetron sputtering technique. The exposure to ionizing radiation in a linear electron accelerator dedicated to medical use has been performed in a controllable manner by delivering up to 50 Gy radiation dose in fractions of 2 Gy radiation dose per 40 s. After the irradiation with electron beams, the surface of layers became nano-size structured. The partial detachment of irradiated layers from the substrates has been revealed only after visualizing their cross sections by scanning electron microscopy. The energy dispersive X-ray spectral analysis of layer cross-sections indicated that the distribution of chemical elements in the samples depends on the radiation dose. The X-ray photoelectron spectroscopy, Fourier transform infrared spectroscopy and X-ray diffraction analysis have shown that the physicochemical processes induced by the ionizing radiation in the magnesium doped hydroxyapatite/chitosan composite coatings do not alter the apatite structure, and Mg remains bonded with the phosphate groups.

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Section: Introductionmentioning

confidence: 99%

The Effects of Electron Beam Irradiation on the Morphological and Physicochemical Properties of Magnesium-Doped Hydroxyapatite/Chitosan Composite Coatings

et al. 2022

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“…Similar to other polymers mentioned above, it has poor mechanical properties, limiting its medical field applicability. In this direction, inorganic particles or other polymers are often incorporated to improve organic polymers’ mechanical properties for bone regeneration [ 67 ]. For example, Bal et al developed scaffolds based on PLA-PEG to properly sustain the incorporation of BMP-2.…”

Section: Polymers Applied In Btementioning

confidence: 99%

Novel Trends into the Development of Natural Hydroxyapatite-Based Polymeric Composites for Bone Tissue Engineering

et al. 2022

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In recent years, the number of people needing bone replacements for the treatment of defects caused by chronic diseases or accidents has continuously increased. To solve these problems, tissue engineering has gained significant attention in the biomedical field, by focusing on the development of suitable materials that improve osseointegration and biologic activity. In this direction, the development of an ideal material that provides good osseointegration, increased antimicrobial activity and preserves good mechanical properties has been the main challenge. Currently, bone tissue engineering focuses on the development of materials with tailorable properties, by combining polymers and ceramics to meet the necessary complex requirements. This study presents the main polymers applied in tissue engineering, considering their advantages and drawbacks. Considering the potential disadvantages of polymers, improving the applicability of the material and the combination with a ceramic material is the optimum pathway to increase the mechanical stability and mineralization process. Thus, ceramic materials obtained from natural sources (e.g., hydroxyapatite) are preferred to improve bioactivity, due to their similarity to the native hydroxyapatite found in the composition of human bone.

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“…Poly(lactic acid) (PLA), as one of the environment-friendly biodegradable polymers, has been in the spotlight owing to its excellent mechanical properties [ 1 , 2 , 3 , 4 ], and because its hydrolysates are not harmful to the human body or to the environment [ 5 , 6 , 7 ]. PLA has been used in several industries, such as food packing [ 8 , 9 ], biomedicine [ 7 , 10 , 11 , 12 ], and electronics [ 13 , 14 ]. With properties being an issue for PLA, many research groups have made lots of effort to improve the mechanical and electrical conductivity of PLA-based composites by adding various carbon nanofillers, such as multiwalled carbon nanotubes (MWNT), carbon black, graphite, and graphene [ 1 , 15 , 16 , 17 , 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

Crystallization Behavior and Electrical Properties of Nanoparticle-Reinforced Poly(lactic Acid)-Based Films

Ren

Lee

et al. 2022

Polymers

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Graphene oxide (GO) and multiwalled carbon nanotubes with silver particles (MWNT-Ag) of different concentrations were used as nanofillers to prepare poly(lactic acid) (PLA) nanoparticle films through the solvent casting method. In this study, the effects of nanoparticles on the crystallization behavior, relationships between the dispersion and electrical properties, and hydrolytic degradation behaviors were investigated for the PLA/MWNT-Ag and PLA/rGO films. Differential scanning calorimetry was used to evaluate the crystallization behaviors of the PLA/MWNT-Ag and PLA/reduced GO (rGO) films. Electron probe microanalysis was performed to characterize the dispersion of MWNT-Ag, and X-ray diffraction and Raman spectroscopy were used to determine the degree of dispersion of rGO in the PLA matrix. The results showed that nanoparticles enhanced the crystallization kinetics of PLA as well as the hydrolytic degradation rate. From the measurement of electrical properties, the electrical conductivity of PLA/MWNT-Ag 1.0 wt% was much higher than that of the pure PLA and PLA/rGO films, showing that MANT and Ag nanoparticles contribute greatly to enhancing the electrical conductivity of the PLA/MWNT-Ag films.

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Effect of electron beam irradiation sterilization on biomedical polylactic acid composite filled with Scomberomorus Guttatus-derived hydroxyapatite

Cited by 13 publications

References 64 publications

The Effects of Electron Beam Irradiation on the Morphological and Physicochemical Properties of Magnesium-Doped Hydroxyapatite/Chitosan Composite Coatings

The Effects of Electron Beam Irradiation on the Morphological and Physicochemical Properties of Magnesium-Doped Hydroxyapatite/Chitosan Composite Coatings

Novel Trends into the Development of Natural Hydroxyapatite-Based Polymeric Composites for Bone Tissue Engineering

Crystallization Behavior and Electrical Properties of Nanoparticle-Reinforced Poly(lactic Acid)-Based Films

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